Clinical trials: Intracranial Hemorrhage
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Chronic Subdural Hematoma, Subdural Drain
The Effect of Subdural Drain Placement After Burr Hole Evacuation of Chronic Subdural Haematomas on Recurrence: a Prospective Randomised-controlled Multi-centre Study
This is a prospective randomised-controlled multi-centre trial based in Hong Kong to determine whether temporary subdural drain placement after burr hole evacuation of a chronic subdural haematoma can reduce the risk of…
- Trial name
- NCT01785797
- Testing
- Silicon subdural drain placement after burr hole evacuation of chronic subdural hematoma
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Kwong Wah Hospital
Subarachnoid Hemorrhage, Aneurysmal
Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx).
- Trial name
- NCT06932640
- Testing
- - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Subarachnoid Hemorrhage, Traumatic
Osmotic Therapy for Patients With Severe Subarachnoid Hemorrhage
The goal of this prospective multi-center observational study is to learn about the osmotic therapy in severe subarachnoid hemorrhage (SAH).
- Trial name
- OSMO-SAH (NCT05858060)
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Subdural Hematoma
The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders
To evaluate Efficacy and Safety of oral Atorvastatin and Dexamethasone on conservative treatment for Chronic Subdural Hematoma (CSDH) patients with Coagulation Disorders
- Trial name
- NCT02192320
- Testing
- Atorvastatin, Atorvastatin and Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
AF - Atrial Fibrillation, Intracranial Hemorrhage, Spontaneous
SAfety and eFfectiveness of cathetER Ablation for Atrial Fibrillation With Intracranial Hemorrhage (SAFER-AF)
SAFER-AF is an investigator-initiated, multicenter, open-label, parallel-group trial comparing catheter ablation versus usual care in patients with atrial fibrillation and intracranial hemorrhage.
- Trial name
- NCT07316270
- Testing
- Catheter Ablation, Usual Care
- Where
- 7 sites in China
- Volunteers
- 646 people
- Sponsor
- Beijing Anzhen Hospital
Fall, Intracranial Bleed
Derivation of a Clinical Decision Rule for Emergency Department Head CT Scanning in Seniors Who Have Fallen
Falls are the leading cause of traumatic death in the elderly with head injury causing half of these deaths. Each year, one in three adults over the age of 65 (seniors) fall, and half of these seniors seek treatment at a hospital…
- Trial name
- NCT03745755
- Where
- Canada
- Volunteers
- 4,308 people
- Sponsor
- McMaster University
Subarachnoid Hemorrhage
FILtration of Subarachnoid Hemorrhage Via SpinaL CAtheteR Extension
The objective of this study is to further demonstrate safety and characterize effectiveness of the Neurapheresis™ System (extracorporeal system and catheter) to remove red blood cells (RBCs) and lysed blood by-products from…
- Trial name
- PILLAR-XT (NCT03607825)
- Testing
- Neurapheresis System
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Minnetronix
Coagulation Disorder, Brain Injuries, Traumatic
Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury
A prospective open-label case-control study will be performed aiming to assess the utility of thromboelastometry (ROTEM) for identification of hemostatic changes, goal-directed coagulation management, and prognosis of…
- Conditions
- Coagulation Disorder, Brain Injuries, Traumatic, Bleeding
- Trial name
- THROMBIN (NCT03616808)
- Testing
- Thromboelastometry-guided haemostatic treatment
- Where
- Lithuania
- Volunteers
- 142 people
- Sponsor
- Lithuanian University of Health Sciences
Neurosurgery, Intracranial Hemorrhages
Arterial Pressure and Surgical Hemostasis in Elective Neurosurgery.
The objective of this observational study is to examine the impact of augmented arterial pressure during the hemostatic phase of elective supratentorial neurosurgery. The primary inquiries it seeks to address are as follows: 1.
- Conditions
- Neurosurgery, Intracranial Hemorrhages, Supratentorial Brain Tumor, Blood Pressure
- Trial name
- HemoStopArt (NCT05874050)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Nimodipine reduces the risk of poor outcome and delayed cerebral ischemia in patients suffering aneurysmal subarachnoid haemorrhage (SAH), but its mode of action is unknown.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral
- Trial name
- NCT04649398
- Testing
- Nimodipine
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Headaches Associated With Subarachnoid Hemorrhage (SAH)
IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery.
- Trial name
- LIMSAH (NCT07054801)
- Testing
- Lidocaine hydrochloride, Methylprednisolone sodium succinate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Daniel Raper, MBBS
Subdural Hematoma
The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma
Subdural hematoma (SDH) is a common condition experienced after head injury. Blood collects on the surface of the brain, causing headaches which can progress to confusion, weakness, or even coma.
- Trial name
- TRACE (NCT05713630)
- Testing
- Tranexamic acid (TXA)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Unity Health Toronto
Intracerebral Hemorrhage
Introduction of Protein S100 in Diagnostics in Minor Brain Injury Patients at Our Hospital
In Patients with minor head injury measurement of protein S100 will be introduced to the emergency departement as another tool to rule out intracerebral bleeding.
- Trial name
- S100 (NCT01122212)
- Where
- Switzerland
- Volunteers
- 128 people
- Sponsor
- Kantonsspital Münsterlingen
Subarachnoid Hemorrhage, Subdural Hematoma
Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.
- Conditions
- Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- BFF (NCT03496545)
- Testing
- Bromocriptine 5 MG, Acetaminophen 650 MG
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intrasaccular neCk Occlusion deVice Treatment of Intracranial Aneurysm in Acute Subarachnoid hemorRhAGE
Rationale: Intrasaccular neck occlusion devices have been used for unruptured aneurysm without safety concerns and good occlusion rates.
- Trial name
- COVERAGE (NCT05171465)
- Testing
- Neqstent or Contour
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Subdural Hematoma, Non-acute
Managing Non-acute Subdural Hematoma Using Liquid Materials：a Chinese Randomized Trial of MMA Treatment
MAGIC-MT study is multi-center, prospective, randomized (1:1) controlled trial designed to show that additional MMA embolization with Onyx in patients with non-acute symptomatic subdural hematoma(SDH) results in reduced hematoma…
- Trial name
- MAGIC-MT (NCT04700345)
- Testing
- Onyx, Burr-hole, Medical Management
- Where
- China
- Volunteers
- 722 people
- Sponsor
- Huashan Hospital
Intracerebral Haemorrhage, Minimally Invasive Treatment
Stereotactic Thrombolysis With Tenecteplase for Supratentorial Intracerebral Hemorrhage
This is a phase III prospective, multi-center, open-label, randomized controlled trial (RCT) with blinded endpoint assessment. It plans to enroll 768 subjects with spontaneous supratentorial intracerebral hemorrhage, who will be…
- Trial name
- STEPS (NCT07208097)
- Testing
- Stereotactic thrombolysis with Tenecteplase
- Where
- 51 sites in China
- Volunteers
- 768 people
- Sponsor
- Tongji Hospital