Clinical trials: Intracerebral Hemorrhage
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
Intracerebral Hemorrhage
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of…
- Trial name
- FASTEST (NCT03496883)
- Testing
- Recombinant Activated Factor VII (rFVIIa)
- Where
- 88 sites in United States, Canada and 4 more
- Volunteers
- 860 people
- Sponsor
- Joseph Broderick, MD
Intracerebral Hemorrhage
Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study
This is single-arm, open-label, safety and feasibility pilot study of ɛ-aminocaproic acid in ICH patients. Consecutive ICH volume with hematoma volume less than 30 mL by ABC/2 method presenting within 3 hours of symptom onset…
- Trial name
- MANICHAN-PILOT (NCT02639819)
- Testing
- ɛ-Aminocaproic Acid
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stroke, Intracerebra Hemorrhage
APEX-STROKE EAGLE Domain (EAGLE)
In this domain of APEX-STROKE, participants with acute spontaneous supratentorial intracerebral haemorrhage (ICH) who meet the domain-specific eligibility criteria will be randomised to either an early surgical bundle or…
- Trial name
- EAGLE (NCT07790354)
- Testing
- Early surgical bundle, Guideline-Based Standard Care
- Volunteers
- 878 people
- Sponsor
- Fudan University
Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment
Effect and Safety of Surgical Intervention for Severe Spontaneous Intracerebral Hemorrhage Patients on Long-term Oral Antiplatelet Treatment
Background: Despite the capability of emergency surgery to reduce the mortality of severe spontaneous intracranial hemorrhage (SSICH) patients, the effect and safety of surgical treatment for severe spontaneous intracranial…
- Conditions
- Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications
- Trial name
- NCT05766865
- Testing
- Emergency neurosurgery, Conservative treatment
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, CVA (Cerebrovascular Accident)
MORbidity PRevalence Estimate In StrokE
Information regarding the likely progress of post-stroke symptoms is vitally important to stroke survivors to allow them to plan for the future and to adjust to life after stroke.
- Conditions
- Stroke, CVA (Cerebrovascular Accident), CVA; Sequelae, Stroke, Ischemic
- Trial name
- MORe PREcISE (NCT03605381)
- Where
- 3 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Aneurin Bevan University Health Board
Intracerebral Hemorrhage, Neurologic Deficits
Multicenter Registry for Assessment of Markers of Early Neurological Deterioration in Primary Intracerebral Hemorrhage
This multicenter observational study will explore the risk factors of early neurological deterioration(END) in patients with primary and to investigate the association between END and outcome.
- Conditions
- Intracerebral Hemorrhage, Neurologic Deficits, Hemorrhagic Stroke, Hemorrhage
- Trial name
- CATCH (NCT05502874)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage, Acute Ischemic Stroke
Cranial Ultrasound for Prehospital ICH Diagnosis
To evaluate the feasibility of Emergency Medical System (EMS)-performed cPOCUS in the field for diagnosis of acute Intracerebral hemorrhage (ICH)
- Trial name
- CUPID_EMS (NCT05492474)
- Testing
- Cranial Point of Care Ultrasound
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Wake Forest University Health Sciences
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Intracranial Hemorrhage
Registration of Idarucizumab for Patients with IntraCranial Hemorrhage
This multicenter, prospective, observational, non-interventional study investigates patients with intracranial hemorrhage under effective anticoagulation with dabigatran or vitamin-K antagonist (VKA).
- Trial name
- RIC-ICH (NCT04062097)
- Testing
- Dabigatran Etexilate Oral Capsule [Pradaxa], Idarucizumab 2.5 GM/50 ML Intravenous Solution [PRAXBIND], Vitamin K antagonist
- Where
- 33 sites in Germany
- Volunteers
- 104 people
- Sponsor
- University Hospital, Essen
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Albumin for Intracerebral Hemorrhage Intervention
The purpose of this study is to find out what effects, good and bad, the medication Albumin has on subjects who have experienced a type of stroke known as an intracerebral hemorrhage (ICH).
- Trial name
- ACHIEVE (NCT00990509)
- Testing
- Albumin, Brain MRI with and without contrast
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Georgetown University
Intracerebral Hemorrhage, Ischemic Stroke
Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke
The purpose of this research study is to determine whether blood pressure treatment regimens with spironolactone are better than blood pressure treatment regimens without spironolactone at lowering blood pressure in stroke…
- Conditions
- Intracerebral Hemorrhage, Ischemic Stroke, Spironolactone
- Trial name
- REDUCE (NCT04760717)
- Testing
- Spironolactone Pill
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Yale University
Ischemic Stroke, Transient Ischemic Attack
Eliquis Acute Stroke Safety Evaluation
Study Design: This is an investigator-initiated prospective, open label, single arm phase IV study. Patients with documented non-valvular atrial fibrillation (AF) with acute TIA (defined as acute focal neurological deficits, with…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Atrial Fibrillation
- Trial name
- EASSE (NCT04435418)
- Testing
- Apixaban
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Intracranial Hemorrhage, Spontaneous
Prediction of Functional Recovery in Patients With Intracerebral Hemorrhage
Currently, we lack sufficiently reliable tools to accurately predict, in the first few hours, the vital prognosis, functional status, and quality of life of patients with intracerebral hemorrhage (ICH).
- Trial name
- PRO-ICH (NCT07728734)
- Testing
- CLINICAL SCORE TO PREDICT FUNCTIONAL OUTCOME, Variables necessary for calculating the score under study (PRO-ICH) will be collected, as well as baseline and 60-120 minutes after baseline of serum blood samples
- Where
- Spain
- Volunteers
- 1,688 people
- Sponsor
- Germans Trias i Pujol Hospital
Cerebral Hemorrhage
Early Intensive Antihypertensive Treatment in High-Risk Population of intraCerebral Hemorrhage ExpanSion Predicted by Artificial Intelligence
The goal of this clinical trial is to clarify the efficacy, safety and feasibility of early intensive antihypertensive treantment in intracerebral hemorrhage (ICH) patients at high risk of hematoma expansion based on artificial…
- Trial name
- ARCHES (NCT06242938)
- Testing
- Early intensive antihypertensive treatment
- Volunteers
- 680 people
- Sponsor
- Beijing Tiantan Hospital
Brain Edema, TBI (Traumatic Brain Injury)
Dynamic Decompressive Craniotomy
Prospective observational study on patients undergoing decompressive craniotomy
- Conditions
- Brain Edema, TBI (Traumatic Brain Injury), Stroke, Acute, Cerebral Hemorrhage
- Trial name
- NCT05051488
- Testing
- Dynamic craniotomy
- Volunteers
- 20 people
- Sponsor
- Rohit Khanna, MD
Stroke, Intracerebral Hemorrhage Basal Ganglia
Neuroendoscopic Hematoma Evacuation Combined With Methylprednisolone Sodium Succinate in the Treatment of Basal Ganglia Intracerebral Hemorrhage at the Early Stage
The aim of this trial is to investigate whether neuroendoscopic hematoma evacuation combined with early use of methylprednisolone sodium succinate can improve the efficacy and safety in the treatment with that of simple…
- Conditions
- Stroke, Intracerebral Hemorrhage Basal Ganglia, Methylprednisolone, Surgery
- Trial name
- NEMP-BGH (NCT06924983)
- Testing
- Simple neuroendoscopic hematoma evacuation, Neuroendoscopic hematoma evacuation combined with sodium methylprednisolone succinate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yong Jiang
Stroke
Autoimmune Phenomena After Acute Stroke
The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.
- Trial name
- ARIMIS (NCT01082783)
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intracerebral Hematoma
Assessment of Intracerebral Hematoma
The study will assess acute intracerebral hematoma expansion within the first 48 hours from the onset using transcranial duplex sonography in patients who have acute intracerebral hematoma , and will also assess the correlation…
- Trial name
- NCT05158660
- Testing
- transcranial duplex sonography
- Volunteers
- 120 people
- Sponsor
- Assiut University