Clinical trials: Intraarticular Injection
Chronic Knee Osteoarthritis
Genicular Nerve and Intra-articular Radiofrequency Versus Platelet Rich Plasma Injection for Knee Osteoarthritis
The social impact of degenerative diseases such as articular cartilage pathology and osteoarthritis (OA) is steadily increasing, because of the continued rise in the mean age of the active population.
- Trial name
- NCT03379883
- Testing
- Pulsed radiofrequency (P-RF), Platelet rich plasma (PRP)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Anterior Cruciate Ligament
Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.
This clinical trial will evaluate the effectiveness of platelet-rich plasma (PRP) injections for patients with anterior cruciate ligament (ACL) injury.
- Trial name
- ACL (NCT07185802)
- Testing
- PRP injection, conventional conservative method (physical therapy, functional bracing, lifestyle modification)
- Where
- Bangladesh
- Volunteers
- 52 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Knee Osteoarthritis
Arthroscopic Debridement Followed by Intra-articular Injection of Micro-fragmented Adipose Tissue in Patients Affected by Knee Osteoarthritis
Background/Objectives: Micro-fragmented adipose tissue is emerging as a promising option for the treatment of various diseases including knee osteoarthritis (OA), though clinical trials are often limited by small sample size and…
- Trial name
- GemsforKnee (NCT06545266)
- Testing
- micro-fragmented adipose tissue injection
- Volunteers
- 41 people
- Sponsor
- Istituto Clinico Humanitas
Joint Osteoarthritis, Knee Osteoarthristis
Clinical Evaluation of TrHCROSS® for Different Joints
This post-market clinical investigation is designed to evaluate the safety and effectiveness of TrHCROSS®, a CE-marked cross-linked hyaluronic acid viscosupplement, in patients with mild to moderate osteoarthritis of the knee…
- Conditions
- Joint Osteoarthritis, Knee Osteoarthristis, Hip Ostearthritis, Shoulder Osteoarthritis
- Trial name
- NCT07870031
- Testing
- TrHCROSS®, Monovisc
- Volunteers
- 150 people
- Sponsor
- i+Med S.Coop.
Transcutaneous, Pulsed Radiofrequency
Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis.
The aim of the present study is to compare the analgesic efficacy of combined transcutaneous pulsed radiofrequency plus genicular nerve block with bupivacaine plus corticosteroid versus intraarticular Hyaluronic acid injections…
- Conditions
- Transcutaneous, Pulsed Radiofrequency, Genicular Nerve Block, Intraarticular
- Trial name
- NCT06710782
- Testing
- Hyaluronic acid, Transcutaneous pulsed radiofrequency
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Osteo Arthritis of the Knee
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question[s] it aims to answer are: Measure the change in average daily knee pain intensity scores from baseline to the end of…
- Trial name
- NCT07819461
- Testing
- Sodium hyaluronate solution - 3.36%, Sterile buffered solution
- Volunteers
- 704 people
- Sponsor
- IBSA Institut Biochimique SA
Post-traumatic Osteoarthritis of the Knee
Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee
This study was a double-blind, randomized, parallel group, proof of concept study comparing FX006 to Kenalog®-40 (triamcinolone acetonide injectable suspension, USP) in patients with post-traumatic osteoarthritis of the knee.
- Trial name
- NCT02468583
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Pivotal Study to Evaluate Efficacy and Safety of SP5M002 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
This is a randomized, double-blind, multicenter, Active Controlled, pivotal clinical trial to assess the efficacy and safety of the novel hexamethylenediamine (HMDA) cross-linked hyaluronate intra-articular injection (SP5M002)…
- Trial name
- NCT06399042
- Testing
- SP5M002 inj, Synovian inj
- Where
- 16 sites in South Korea
- Volunteers
- 297 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Osteoarthritis, Knee
PAAG-OA Treatment for Knee Osteoarthritis
This is a multi-centre, prospective, open-label, uncontrolled, clinical investigation followed by an open-label extension clinical investigation to evaluate PAAG-OA in patients with knee osteoarthritis.
- Trial name
- IDA (NCT04179552)
- Testing
- PAAG-OA
- Where
- 3 sites in Denmark
- Volunteers
- 49 people
- Sponsor
- Contura
Osteo Arthritis of Hip
Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With OA of the Hip Compared to Intra-articular Steroid Injections
This will be a single-center, prospective, single-blinded randomized clinical trial to investigate the effectiveness of using cooled RFA for the treatment of OA hip pain and function in subjects treated with cooled RFA compared…
- Trial name
- NCT03647332
- Testing
- Cooled RFA treatment, Steroid Drug
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis Patient
Study of Evaluating the Duration of Efficacy of One Intra Articular Injection of Sodium Hyaluronate 2.0% in Patients With Painful Osteoarthritis of the Knee
A pilot, open, randomised, controlled, add-on study evaluating the duration of efficacy of one intra articular injection of sodium hyaluronate 2.0% in patients with painful osteoarthritis of the knee
- Trial name
- NCT01288001
- Testing
- Ostenil plus
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- TRB Chemedica
Facet Joint Pain, Back Pain
Safety and Efficacy of XT-150 for Facet Joint Osteoarthritis Pain
This is a Phase 2a safety and efficacy study of XT-150 in adult participants experiencing back pain due to inflammation of the facet joint, also known as facet joint osteoarthritis (FJOA), and who are eligible for intra articular…
- Conditions
- Facet Joint Pain, Back Pain, Inflammation
- Trial name
- NCT05196919
- Testing
- XT-150
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- Xalud Therapeutics, Inc.
Low Back Pain
Intraarticular Lumbar Joint Corticosteroid Injection(s) as a Treatment of Chronic Low Back Pain in a Selected Population
Subjects (N=120) who have had non-radicular low back pain, believed by clinical assessment and imaging to be consistent with lumbar zygapophysial joint (Z-joint) generated pain, who have failed conservative therapy including…
- Trial name
- NCT01382771
- Testing
- Intra-articular corticosteroid injection, Intra-articular saline injection
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Florida
Osteoarthritis, Knee
Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoarthritis
A single-blind randomized controlled design intended for the assessment of safety and performance of a single intra-articular injection of the IMD.
- Trial name
- PIONEER (NCT05214807)
- Testing
- KiOmedine® CM-Chitosan, Synvisc-One®
- Where
- Belgium
- Volunteers
- 104 people
- Sponsor
- Kiomed Pharma
De Quervain Disease
Effect of Ultrasound-guided Corticosteroid Injection Versus Palpation-guided Injection for de Quervain's Disease
The purposes of this study are to compare the effectiveness and side effects of US-guided and palpation-guided corticosteroid injections for de Quervain's disease.
- Trial name
- NCT04260984
- Testing
- US-guided injection, palpation-guided injection
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Knee Osteoarthritis
Efficacy and Safety of Hymovis ONE® (32mg/4ml) Intrarticular Injection in Active Patients With Knee Overuse Syndrome
The aim of this study is to evaluate the efficacy and safety of Hymovis® ONE (32 mg/4 ml) single intra-articular injection, in the management of pain caused by knee osteochondral lesions.
- Trial name
- NCT04661111
- Testing
- Hymovis® ONE (32 mg/4 ml)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Diabetes, Knee Osteoarthritis
Knee Steroid Injection and Blood Sugar Signatur
A prospective, observational study assessing the relationship between HbA1c level and the post-injection blood glucose signature.
- Trial name
- NCT04317404
- Testing
- 40 mg Triamcinolone acetonide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center
Knee Osteoarthritis
a Single Intraarticular Injection of PRP for Early Knee OA
This study aimed to investigate the efficacy of a single intraarticular injection of PRP for the treatment of early knee OA.
- Trial name
- NCT04027738
- Testing
- PRP
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis, Knee
Efficacy and Safety of Intraarticular Sodium Hyaluronate Single Injection in Patients With Osteoarthritis of the Knee
A Phase III, prospective, multicentre, non-controlled, with consecutive participant enrollment in order to evaluate the efficacy, safety and duration of the effects of the viscosupplementation with a preparation of sodium…
- Trial name
- NCT03852914
- Testing
- Sodium hyaluronate 2%
- Where
- 10 sites in Spain
- Volunteers
- 93 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Osteoarthritis of the Knee
The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator
Osteoarthritis is the most common disease effecting human beings with incidence of about 20% and prevalence close to 80% of the adult population.
- Trial name
- NCT00422643
- Testing
- Sodium hyaluronate (hyaluronic acid)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center