Clinical trials: Intraarticular Injection
Knee Osteoarthritis
Study of Cingal for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up
Extension study to Cingal 16-02 to obtain 39-week safety and efficacy follow-up data
- Trial name
- Cingal17-02 (NCT03390036)
- Testing
- Cingal, Monovisc, Triamcinolone Hexacetonide
- Where
- 17 sites in Hungary, Poland
- Volunteers
- 526 people
- Sponsor
- Anika Therapeutics, Inc.
Knee Osteoarthritis
Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Introduction: Osteoarthritis of the knee is a very common disease. However there are few treatment options for these patients. Botulinum toxin type A is an option for chronic pain.
- Trial name
- NCT02829281
- Testing
- Botulinum Toxin Type A, Triamcinolone hexacetonide, Saline
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Knee
Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of intraarticular injection of Cell-free Stem Cell-derived Extract Formulation for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04971798
- Testing
- Cell-free Stem Cell-derived Extract Formulation (CCM)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- General Therapeutics
Knee Osteoarthritis
Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections
This study will compare the efficacy of intra-articular betamethasone injection to intra-articular ketorolac injection for symptomatic treatment of knee osteoarthritis in an equivalence study using a double-blinded, randomized…
- Trial name
- NCT02612272
- Testing
- Ketorolac, Betamethasone
- Where
- United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Knee Osteoarthristis
A Study to Investigate the Effectiveness, Safety, and Tolerability of MAG200 Solution for Intra-articular Injection Compared With Placebo in Participants Aged 35 to 75 Years of Age With Symptomatic Osteoarthritis of the Knee.
The purpose of this study is to confirm whether MAG200 (20M or 100M) will improve pain and function of participants with osteoarthritis of the knee compared with placebo. In addition, the two strengths of MAG200 will be compared.
- Trial name
- nexcell-OAK (NCT07106229)
- Testing
- allogeneic human adipose-derived mesenchymal stem cells
- Volunteers
- 573 people
- Sponsor
- Magellan Stem Cells
Temporomandibular Arthritis
Intra-articular Injection for the Relief of Temporomandibular Joint Pain
Which is more effective in the treatment of nonspecific temporomandibular osteoarthritis: platelet-rich plasma (PRP), hyaluronic acid, or triamcinolone acetonide?
- Trial name
- NCT07571265
- Testing
- platelet rich plasma and triamcinolone acetonide and hyaluronic acid and saline intra articular injection
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis, Knee
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis
The goal of this randomized clinical trial is to learn whether taking ibuprofen, a nonsteroidal anti-inflammatory drug, after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee…
- Trial name
- NCT07766330
- Testing
- Leukocyte-Rich Platelet-Rich Plasma, ibuprofen, Acetaminophen
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of São Paulo
Adhesive Capsulitis of the Shoulder
Comparison of the Short-term Clinical Effects of Anterior Extra-articular and Posterior Intra-articular Administration of Ultrasound-guided Steroid Injection in the Treatment of Adhesive Capsulitis.
In the treatment of adhesive capsulitis, conservative treatment usually gives successful results, and steroid injection is an effective method that is frequently preferred among conservative treatment modalities.
- Trial name
- NCT05668286
- Testing
- A combination of 1 mL of triamcinolone acetonide (40 mg/mL) and 1 mL of prilocaine hydrochloride (2%)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kartal City Hospital
Osteoarthritis, Knee
Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
To assess if there are any differences among platelet-rich plasma, hyaluronic acid, and corticosteroid knee intra-articular injection regarding function and pain.
- Trial name
- NCT04980105
- Testing
- Platelet-rich plasma, Hyaluronic acid, Methylprednisolone acetate injectable suspension (DEPO-MEDROL®)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Wasit
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Glenohumeral Osteoarthritis
Hymovis® Intra-articular Injections vs Corticosteroids Intra-articular Injections in Patients Affected by Glenohumeral Osteoarthritis:
This monocentric randomized open-label study aims to assess the efficacy and safety of a treatment with medium molecular weight hyaluronic acid (HA) compared to a treatment with corticosteroids on patients affected by…
- Trial name
- NCT06043544
- Testing
- Hyaluronic Acid 24 MG in 3 mL Prefilled Syringe, Corticosteroid injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Concordia Hospital Rome
Knee Osteoarthritis
Intra Articular Injection of Microfat and PRP in Knee Osteoarthritis
The hypothesis of this project is that the injection of an innovative treatment (microfat and dose of autologous PRP) allows to delay knee arthroplasty in patients with knee OA resistant to medical treatment.
- Trial name
- MICROPREP (NCT04352075)
- Testing
- Autologous biologic drug of innovative therapy /cell therapy drug
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Clinique Juge
Anterior Cruciate Ligament Injuries, Anesthesia Injection Site
Ropivacaine and Midazolam by Intraarticular vs Epidural Administration in Arthroscopic ACL
Compare of the effectiveness of the use of ropivacaine and midazolam by intraarticular vs epidural administration on post-operative analgesia after isolated arthroscopic anterior cruciate ligament (ACL) reconstruction with…
- Conditions
- Anterior Cruciate Ligament Injuries, Anesthesia Injection Site, Knee Injuries
- Trial name
- NCT05078372
- Testing
- ropivacaine and midazolam intraarticular administration, ropivacaine and midazolam epidural administration
- Where
- Mexico
- Volunteers
- 108 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Breast Neoplasm, Shoulder Capsulitis
Improvement of Range of Motion in Frozen Shoulder in Breast Cancer Survivors
The prevalence of shoulder joint disease is high in breast cancer patients. The cause of adhesive capsulitis is not clearly identified.
- Conditions
- Breast Neoplasm, Shoulder Capsulitis, Range of Motion
- Trial name
- NCT04640220
- Testing
- Intra-articular steroid injection
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Yeungnam University Hospital
Rheumatological Injection, Pain Management
The Value of Standardized Respiratory Rate Monitoring Exercises During Rheumatological Injection Procedures
The goal of this clinical trial is to demonstrate the non-inferiority of standardized breathing control exercises on perceived pain during rheumatological injections procedures compared to standard care consisting of the addition…
- Conditions
- Rheumatological Injection, Pain Management, Respiratory Monitoring
- Trial name
- Respi-IR (NCT07172984)
- Testing
- Anesthesia, breathing group
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Metropole Savoie
ACL Reconstruction, Intraarticular Injection
Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.
This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft.
- Conditions
- ACL Reconstruction, Intraarticular Injection, PRP
- Trial name
- NCT07470359
- Testing
- PRP injection
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
TMJ Disc Displacement With Reduction
Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management
The aim of this study is to evaluate the efficacy of hyaluronic acid and I-PRF mixture for intra-articular injection following arthrocentesis in the management of TMJ reducible disc displacement.
- Trial name
- NCT07683650
- Testing
- 18 joints that receive arthrocentesis using 100 ml of ringer lactate solution, Arthrocentesis followed by hyaluronic acid injection, Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Osteoarthritis
An Observational Study Evaluating the Safety, Tolerability, and Efficacy of Treatment of SM04690 or Placebo Previously Injected in the Target Knee Joint of Subjects With Moderately to Severely Symptomatic Osteoarthritis
This long-term extension study is designed to monitor the long-term safety, tolerability, and efficacy of treatment of SM04690 or placebo previously injected in the target knee joints of subjects with moderately to severely…
- Trial name
- NCT02951026
- Testing
- Not applicable (no therapy is administered as part of this study)
- Where
- 62 sites in United States
- Volunteers
- 703 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteochondritis Dissecans
Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
This study plans to learn more about ways to treat a joint problem in the knee called Juvenile Osteochondritis Dissecans (OCD). The goal of this study is to see if injecting platelet-rich plasma (PRP) into the knee can help knee…
- Trial name
- NCT02397278
- Testing
- Platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver