Clinical trials: Intraarticular Injection
Symptomatic Hip Osteoarthritis
The Efficacy Study of Sodium Hyaluronate to Treat Symptomatic Hip Osteoarthritis
To demonstrate the difference in terms of symptomatic efficacy between ADANT® sodium hyaluronate and placebo following an intra-articular injection in patients with symptomatic osteoarthritis of the hip.
- Trial name
- NCT00330135
- Testing
- Sodium hyaluronate
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Daiichi Sankyo
Knee Osteoarthritis
A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is the most common joint disease affecting millions of people around the world, for which there is unfortunately no cure.
- Trial name
- NCT02740231
- Testing
- JTA-004 intra-articular injection, Reference product intra-articular injection
- Volunteers
- 173 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis of the Shoulder, Adhesive Capsulitis
Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
This is a double-blind study to evaluate the efficacy and safety of FX006 in patients with glenohumeral osteoarthritis (OA) or shoulder adhesive capsulitis (AC).
- Trial name
- NCT04160091
- Testing
- FX006, Normal Saline
- Where
- 27 sites in United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis of the Knee
Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
The purpose of this study was to assess the safety and efficacy of FX006 for the treatment of pain in patients with osteoarthritis of the knee.
- Trial name
- NCT02357459
- Testing
- FX006, TCA IR 40
- Where
- 38 sites in United States, Australia and 6 more
- Volunteers
- 486 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis, Osteoarthritis of the Knee
Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis
This study looked at how safe and effective a hyaluronic acid-based injection (called DIART ONE or EASYGO ONE) is for people with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease
- Trial name
- NCT06927934
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Yuria-Pharm
Osteoarthritis
Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA
The purpose of this study is to demonstrate non-inferiority of three weekly intra-articular injections of SUPARTZ to three weekly intra-articular injections of Euflexxa for the relief of knee OA.
- Trial name
- NCT02110238
- Testing
- Supartz, Euflexxa
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Bioventus LLC
Osteoarthritis
Efficacy and Safety of Intraarticular Injections of Hyalgan in the Treatment of Osteoarthritis of the Knee
Evaluate the efficacy and safety of Hyalgan, at a dose of 20mg/2ml administered as 5 intraarticular injections at weekly intervals, for the sustained relief of pain and amelioration of joint dysfunction in patients of OA of the…
- Trial name
- NCT01319461
- Testing
- Hyalgan, sterile normal saline
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Med Pharma Co., Ltd.
Bilateral Knee Osteoarthritis
Study to Compare Exposure of TA Following Administration of Either FX006 or TAcs in Patients With Bilateral Knee OA
This is a randomized, open-label, parallel group study to compare systemic exposure of triamcinolone acetonide following administration into both knees of either FX006 or TAcs.
- Trial name
- NCT03378076
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis
The purpose of this study is to determine whether MM-II is effective in the treatment of osteoarthritis, in direct comparison with an approved hyaluronic acid preparation.
- Trial name
- NCT01365260
- Testing
- MM-II, DurolaneTM
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Moebius Medical Ltd.
Osteoarthritis of the Knee
An Efficacy and Safety Study of Two Doses of Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee
This study will evaluate the efficacy of two doses of Intra-Articular Injection of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT01839331
- Testing
- 4 mL injection of Ampion, 10 mL Injection of Ampion
- Volunteers
- 329 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Severe Osteoarthritis of the Knee
Study of Ampion for the Treatment of Pain and Function in Patients With Severe Osteoarthritis of the Knee.
The purpose of this study is to confirm the safety and efficacy of Ampion for the treatment of pain and function in patients with severe osteoarthritis of the knee.
- Trial name
- NCT03988023
- Testing
- Ampion, Saline
- Where
- United States
- Volunteers
- 1,043 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05449132
- Testing
- RTX-GRT7039
- Where
- 81 sites in United States, Denmark and 3 more
- Volunteers
- 466 people
- Sponsor
- Grünenthal GmbH
Knee Osteoarthritis
Pilot, Prospective, Comparative Multicentric Study Evaluating the Effects on the Arthrosis Biomarkers, the Clinical Effectiveness, the Tolerance of an Intra-articular Injection of Hyaluronic Acid KARTILAGE CROSS Versus Placebo in Patients Suffering From Knee Osteoarthritis
Intra-articular hyaluronic acid injections, also known as viscosupplementation, are a treatment option for knee osteoarthritis that serves to restore the decreasing rheological properties of synovial fluid.
- Trial name
- EPIKART (NCT02951585)
- Testing
- KARTILAGE CROSS
- Volunteers
- 81 people
- Sponsor
- Laboratoires Vivacy
Glenohumeral Osteoarthritis
Performance and Safety of HyalganBio® Intra-Articular Injections as Add-On to Physical Exercise for Symptomatic Glenohumeral Osteoarthritis
This investigation evaluates performance and safety of three intra-articular injections of HyalganBio®, combined with a Physical Exercise Program (PEP) in subjects with glenohumeral osteoarthritis.
- Trial name
- NCT07520708
- Testing
- Hyaluronic acid plus Physical Exercise Program (PEP)
- Where
- 6 sites in Italy
- Volunteers
- 72 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Prosthetic Joint Infection (PJI)
A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with…
- Trial name
- NCT07858916
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics
- Where
- China
- Volunteers
- 40 people
- Sponsor
- TenNor Therapeutics (Zhongshan) Limited
Knee Osteoarthritis
Efficacy and Safety of ELIXCYTE Intra-articular Injection in Subject With Knee Osteoarthritis
This is a Phase III, double-blinded, placebo-controlled, multicenter study to investigate the efficacy and safety of a new study intervention, ELIXCYTE, compared to placebo (normal saline) in subjects with knee osteoarthritis.
- Trial name
- NCT05526001
- Testing
- ELIXCYTE, Saline
- Where
- 4 sites in Taiwan
- Volunteers
- 165 people
- Sponsor
- UnicoCell Biomed CO. LTD
Osteoarthritis of the Knee
Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to evaluate the safety, pharmacokinetics and pharmacodynamics of FX006 in patients with osteoarthritis of the knee.
- Trial name
- NCT01487200
- Testing
- FX006 10 mg, FX006 40 mg, FX006 60 mg
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Saline-Controlled Study of nSTRIDE APS for Knee Osteoarthritis
A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the efficacy of a single dose of Autologous Protein Solution (APS) in patients with Osteoarthritis (OA) of the knee.
- Trial name
- PROGRESS IV (NCT02905240)
- Testing
- nSTRIDE APS, Saline
- Where
- 27 sites in United States
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APS
This study will document treatment effects, changes in quality of life, procedure complications, adverse events, healthcare resource utilization, and further needed intervention(s) following treatment with nSTRIDE autologous…
- Trial name
- PROGRESS III (NCT02580643)
- Testing
- APS
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of the Knee
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks.
- Trial name
- NCT00988091
- Testing
- 1.2% Sodium Hyaluronate, Buffered Saline
- Where
- 34 sites in United States
- Volunteers
- 596 people
- Sponsor
- Ferring Pharmaceuticals