Clinical trials: Intraarticular Injection
Recovery Following Partial Medial Meniscectomy
Follow-up Study of Chondrogen® Delivered by Intra-Articular Injection Following Meniscectomy
The objective of the present study is to establish the long-term safety of an intra-articular injection of human mesenchymal stem cells (hMSCs) (Chondrogen).
- Trial name
- NCT00702741
- Testing
- Chondrogen
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- Mesoblast International Sàrl
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Osteoarthritis of the Knee
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks.
- Trial name
- NCT00988091
- Testing
- 1.2% Sodium Hyaluronate, Buffered Saline
- Where
- 34 sites in United States
- Volunteers
- 596 people
- Sponsor
- Ferring Pharmaceuticals
Osteoarthritis of the Shoulder, Adhesive Capsulitis
Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
This is a double-blind study to evaluate the efficacy and safety of FX006 in patients with glenohumeral osteoarthritis (OA) or shoulder adhesive capsulitis (AC).
- Trial name
- NCT04160091
- Testing
- FX006, Normal Saline
- Where
- 27 sites in United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA
An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX 4975-05 Intra-articular Injection in Subjects with Chronic, Moderate-to-Severe Osteoarthritis Knee Pain.
- Trial name
- NCT03661996
- Testing
- CNTX-4975-05, Lidocaine without epinephrine, ElastoGel
- Where
- 28 sites in United States
- Volunteers
- 854 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis
Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee
An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in patients who have pain associated with osteoarthritis of the knee despite…
- Trial name
- NCT05377489
- Testing
- RTX-GRT7039
- Where
- 96 sites in United States, Bulgaria and 5 more
- Volunteers
- 714 people
- Sponsor
- Grünenthal GmbH
Prosthetic Joint Infection (PJI)
A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with…
- Trial name
- NCT07858916
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics
- Where
- China
- Volunteers
- 40 people
- Sponsor
- TenNor Therapeutics (Zhongshan) Limited
Osteoarthritis of Knee
A Clinical Trial to Evaluate the Safety and Efficacy of Retreatment With Intra-articular LBSA0103 Injections in the Patients With Osteoarthritis of the Knee
To assess the safety and efficacy of LBSA0103 (BDDE cross-linked sodium hyaluronate gel) when it is administered for the second time 26 weeks after its first administration in patients with osteoarthritis of the knee.
- Trial name
- NCT02122601
- Testing
- LBSA0103 (BDDE cross-linked sodium hyaluronate gel)
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- LG Life Sciences
Knee Osteoarthritis
Intra-Articular Injection in Moderate Knee Osteoarthritis
AqueousJoint is a new intra-articular (IA) injectable joint lubricant for patients suffering from knee Osteoarthritis developed by Liposphere LTD.
- Trial name
- NCT05412836
- Testing
- AqueousJoint
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Lipo-Sphere
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Hip
Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis
This is a two-part, multi-center, randomized, double-blind, placebo-controlled, parallel-group study in patients with hip OA. Approximately 70 patients will be enrolled in Part I and approximately 440 patients will be enrolled in…
- Trial name
- NCT03793010
- Testing
- FX006, Normal saline
- Where
- 32 sites in United States
- Volunteers
- 70 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
Knee Osteoarthritis
Study on the Use of a Concentrated Growth Factor Preparation Kit for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to evaluate the effectiveness and safety of an autologous platelet-rich concentrated growth factor (CGF) preparation kit for the treatment of knee osteoarthritis in patients diagnosed with this…
- Trial name
- NCT06869200
- Testing
- Concentrated Growth Factor (CGF) Intra-articular Injection, Platelet-Rich Plasma (PRP) Intra-articular Injection
- Where
- 3 sites in China
- Volunteers
- 104 people
- Sponsor
- Guangdong Hongzhi Health Technology
Knee Osteoarthritis
A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is the most common joint disease affecting millions of people around the world, for which there is unfortunately no cure.
- Trial name
- NCT02740231
- Testing
- JTA-004 intra-articular injection, Reference product intra-articular injection
- Volunteers
- 173 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis, Knee
Mesenchymal Stem Cells for The Treatment of Knee Osteoarthritis (KOA).
The clinical study with UMC119-06-05 is designed to investigate the safety in patients with mild to moderate knee osteoarthritis (KOA).
- Trial name
- NCT04893174
- Testing
- UMC119-06-05, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Osteoarthritis, Knee
nSTRIDE APS Versus Hyaluronic Acid for Knee Osteoarthritis
This is a two-phase multicenter, double-blind, randomized, prospective evaluation of intra-articular injection(s) comparing APS to intra-articular HA injection(s).
- Trial name
- NCT03182374
- Testing
- nSTRIDE APS, Synvisc-One
- Where
- 14 sites in Belgium, Denmark and 8 more
- Volunteers
- 252 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA
The purpose of this study is to demonstrate non-inferiority of three weekly intra-articular injections of SUPARTZ to three weekly intra-articular injections of Euflexxa for the relief of knee OA.
- Trial name
- NCT02110238
- Testing
- Supartz, Euflexxa
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Bioventus LLC
Cartilage Injury of Knee
A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the Knee
This is a Phase 2, double-blind, multicenter, randomized, placebo-controlled trial to evaluate the efficacy and safety of Sprifermin (AS902330) (recombinant human fibroblast growth factor-18 [rhFGF-18]) as an adjunct treatment to…
- Trial name
- NCT01689337
- Testing
- Sprifermin (AS902330)
- Volunteers
- 1 people
- Sponsor
- EMD Serono
Osteoarthritis of the Knees
Evaluation of Intra-articular CX-011 to Treat Moderate to Severe Pain From Knee Osteoarthritis
Study is designed to evaluate the safety and effectiveness of a drug called CX-011 to treat pain in patients with osteoarthritis of the knee.
- Trial name
- NCT07308834
- Testing
- CX-011
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- CarthroniX, Inc.