Clinical trials: Intra-abdominal Infection
Abdominal Compartment Syndrome, Intra-abdominal Hypertension
Peritoneal Vacuum Therapy to Reduce Inflammatory Response From Abdominal Sepsis/Injury
This pilot study will evaluate the effectiveness in actively removing the peritoneal fluid through the use of a commercial suction device compared to passive drainage of the same peritoneal fluid drained through standard surgical…
- Trial name
- SAD (NCT01355094)
- Testing
- KCI AbThera, "Stampede" VAC
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Pneumonia, Abdominal Infection
Target Site Pharmacokinetics of Doripenem at Steady State in Intubated Intensive Care Patients
The investigators will measure the pharmacokinetics of doripenem in skeletal muscle, subcutaneous adipose tissue, bronchoalveolar lavage and plasma of intubated intensive care patients.
- Conditions
- Pneumonia, Abdominal Infection, Urinary Tract Infection
- Trial name
- NCT01414959
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Vienna
Abdominal Sepsis, Peritonitis
Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery
Septic shock of intra-abdominal origin is likely due to Gram-negative bacteria or mixed pathogens and associated with high levels of endotoxin.
- Conditions
- Abdominal Sepsis, Peritonitis, Colon Perforation
- Trial name
- NCT01646229
- Testing
- Polymyxin-B hemoperfusion, Control
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Geneva
Nausea, Vomiting
Intra-abdominal at Cesarean Section: A Randomized Controlled Trial
The purpose of this study is to determine if intra-abdominal irrigation at the time of cesarean delivery increased maternal GI discomfort without affecting infection rates.
- Trial name
- NCT01479712
- Testing
- Normal Saline Irrigation
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Complicated Intra-Abdominal Infections, cIAIs
Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE)
Determine the PK and safety and tolerability of aztreonam-avibactam (ATM-AVI) in the treatment of hospitalized adults with cIAI
- Trial name
- NCT02655419
- Testing
- ATM-AVI, Metronidazole
- Where
- 11 sites in France, Germany and 1 more
- Volunteers
- 40 people
- Sponsor
- Pfizer
Diet, Healthy, Food
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
This is a research study to determine if a particular method of providing nutrition improves the clinical outcomes of patients in the intensive care unit (ICU) who have undergone abdominal surgery and would require nutrition…
- Conditions
- Diet, Healthy, Food, Nutrition, Intensive Care
- Trial name
- PASTDUe (NCT05127109)
- Testing
- Nutrition Ecosystem pathway, Comparator
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Critical Illness, Acute Kidney Injury
Collective Accuryn Physiologic Signals and Signatures
The CAPSS Study is a retrospective and prospective, multi-center, single-arm post-market data collection study with an FDA cleared device.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Septic Shock
- Trial name
- CAPSS (NCT03817281)
- Testing
- Accuryn Monitoring System
- Where
- United States
- Sponsor
- Potrero Medical
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Community Acquired Bacterial Pneumonia, Complicated Intra-Abdominal Infection
Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia
The main purpose of this study is to compare the safety of tigecycline versus a ceftriaxone regimen in pediatric subjects (aged 8 to 17 years) with complicated intra-abdominal infections (cIAI) and community acquired pneumonia…
- Trial name
- NCT01602874
- Testing
- Tigecycline, cIAI: Ceftriaxone with metronidazole, plus if applicable aminoglycoside, CAP: Ceftriaxone, plus if applicable oral clarithromycin
- Sponsor
- Pfizer
Intra-abdominal Infections
A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection
The purpose of this study is to evaluate the clinical efficacy and safety in Japanese adult subjects with Intra-abdominal/Pelvic infections receiving Metronidazole IV 1,500-2,000 mg/day in combination with ceftriaxone sodium.
- Trial name
- NCT01473836
- Testing
- Metronidazole, Ceftriaxone sodium
- Where
- 15 sites in Japan
- Volunteers
- 38 people
- Sponsor
- Pfizer
Perioperative Hyperoxygenation, Wound Infection
Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy
The study evaluates the role of supplemental hyper-oxygenation given perioperatively on wound site infection after appendectomy.
- Trial name
- NCT02687217
- Testing
- oxygen
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Infections, Intestinal
GSK2251052 in the Treatment of Complicated Intra-abdominal Infections
This study is being conducted to evaluate the safety, efficacy and pharmacokinetics/pharmacodynamics of GSK2251052 in subjects with complicated intra abdominal infections.
- Trial name
- NCT01381562
- Testing
- Drug: GSK2251052, Meropenem
- Where
- 31 sites in United States, Canada and 5 more
- Volunteers
- 15 people
- Sponsor
- GlaxoSmithKline
Invasive Candidiases, Abdominal Infection
A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
This is a multicenter, prospective, open-label, randomized trial. Patients with severe abdominal condition developing severe sepsis or septic shock and receiving broad spectrum antibiotic and antifungal treatment will be…
- Trial name
- NCT03090334
- Testing
- De-escalation
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Abdominal Sepsis
Assessment of Peritoneal Immune Response in Patients With Severe Intra-abdominal Sepsis Managed With Laparostomy and Vacuum Assisted Closure (VAC)
Protocol Synopsis Protocol title: Assessment of peritoneal immune response in patients with severe intra-abdominal sepsis managed by laparostomy and VAC Purpose: Assessment of peritoneal immune response in patients with severe…
- Trial name
- NCT01410526
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Appendicitis, Cholecystitis
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
This is a phase 3b/4 randomized, open-label, comparative, multicenter study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI (Complicated Intra-Abdominal…
- Conditions
- Appendicitis, Cholecystitis, Cross Infection, Diverticulitis
- Trial name
- NCT00195351
- Testing
- tigecycline, ceftriaxone sodium + metronidazole
- Where
- 66 sites in United States, Argentina and 4 more
- Volunteers
- 467 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Abdominal Infection
Management and Outcome of Mesh Infection After Abdominoplasty in a Tertiary Care Centre
Hernia repair is among most frequent surgical interventions. The use of abdominal mesh in hernia repair has become the Gold Standard strategy, reducing the risk of relapse.
- Trial name
- MOCOMI (NCT06682091)
- Where
- France
- Volunteers
- 209 people
- Sponsor
- Hospices Civils de Lyon
Intra-abdominal Infection, Complicated Intra-abdominal Infection
Study of Ceftolozane/Tazobactam (MK-7625A) in Combination With Metronidazole in Japanese Participants With Complicated Intra-abdominal Infection (MK-7625A-013)
This is a Phase 3, multi-site, non-randomized, open-label study evaluating the safety and efficacy of MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g) plus metronidazole 500 mg for the treatment of Complicated Intra-abdominal…
- Trial name
- NCT02739997
- Testing
- MK-7625A 1.5 g (ceftolozane 1 g/tazobactam 0.5 g), metronidazole 500 mg
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Mycoses
A Study to Evaluate Pre-emptive Treatment for Invasive Candidiasis in High Risk Surgical Subjects
Subjects with intra-abdominal infection requiring surgery and Intensive Care Unit stay will be treated early with micafungin or placebo to determine the incidence and time to confirmation of fungal infection.
- Trial name
- INTENSE (NCT01122368)
- Testing
- micafungin
- Where
- 56 sites in Austria, Belgium and 13 more
- Volunteers
- 252 people
- Sponsor
- Astellas Pharma Inc
Complicated Intra-abdominal Infection
A Study to Evaluate Ertapenem Versus It's Comparator in the Treatment of Complicated Intra-abdominal Infections in Adults (0826-050)(COMPLETED)
This was a prospective, randomized, controlled, open, and multi-center trial conducted to compare the clinical efficacy and safety of ertapenem with it's comparator before or following adequate surgical management of complicated…
- Trial name
- NCT00157898
- Testing
- MK0826; ertapenem sodium, Comparator: ceftriaxone + metronidazole
- Volunteers
- 134 people
- Sponsor
- Merck Sharp & Dohme LLC
Abscess, Intra-Abdominal
Moxifloxacin Plus Metronidazole Versus Piperacillin/Tazobactam for the Treatment of Patients With Intra-abdominal Abscesses
The study is contemplating the antibiotic therapy of intraabdominal abscesses. These abscesses are a serious problem in surgical practice.
- Trial name
- MEMO (NCT00629135)
- Testing
- Moxifloxacin/Metronidazole or Piperacillin/Tazobactam
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Hannover Medical School