Clinical trials: Intestinal Permeability
Autism, Inflammation
Intestinal Inflammation and Carbohydrate Digestion in Autistic Children
The purpose of the study is to find correlations between non-invasive fecal tests of intestinal inflammation and macro- and microscopic evaluation of duodenal and colonic histology, disaccharidase activity, and intestinal…
- Trial name
- NCT00227487
- Testing
- Stool collection, Administration of carbohydrate solution during clinically indicated endoscopy, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- Massachusetts General Hospital
Ulcerative Colitis
Role of Healthy Bacteria in Ulcerative Colitis
Intestinal inflammation seen in inflammatory bowel disease (IBD) results from an altered mucosal immune response to luminal bacterial antigens.
- Trial name
- NCT01479660
- Testing
- Control, Probiotic
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Dehydration, Indomethacin
The Effect of Dehydration on Intestinal Permeability
In this study, the effect of dehydration by sauna exposure on the intestinal permeability in 20 healthy subjects is investigated.
- Trial name
- NCT03620825
- Testing
- Dehydration by sauna exposure, Indomethacin
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Liver Cirrhoses
Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)
This study seeks to investigate whether non-selective beta blocker treatment decreases intestinal permeability in cirrhotic patients by altering the expression of genes encoding intercellular junction proteins.
- Trial name
- NCT02484573
- Testing
- Propanolol
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Malnutrition, Child
Effect of an Alternative RUTF on Intestinal Permeability in Children With Severe Acute Malnutrition
Ready-to-use therapeutic food (RUTF) is the standard of care for the treatment of SAM. UNICEF requires that there be no oil separation in these products necessitating the use of emulsifiers.
- Trial name
- NCT04334538
- Testing
- S-RUTF, oat RUTF
- Where
- Sierra Leone
- Volunteers
- 129 people
- Sponsor
- Washington University School of Medicine
Colitis, Ulcerative
A First Time in Human Study to Evaluate the Safety and Tolerability of GSK4381406 in Healthy Participants
This is a 3-part First Time in Human (FTIH) study to evaluate the safety, tolerability, and pharmacokinetics (PK) profile of GSK4381406 following administration of single ascending doses (Part 1), repeat ascending doses (Part 2)…
- Trial name
- NCT05999708
- Testing
- GSK4381406, Indomethacin
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as…
- Conditions
- Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
- Trial name
- NCT07125001
- Testing
- Ataulfo mango
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Infertility Female, Zonulin
Effect Of The Mediterranean Diet On Zonulin And Infertility
The goal of this clinical trial is to learn if mediterranean diet works to treat infertility in women. It will also learn about the initial and end of study zonulin levels of mediterranean diet and control group.
- Conditions
- Infertility Female, Zonulin, Intestinal Permeability, Mediterranean Diet
- Trial name
- NCT07072936
- Testing
- mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- SINEM BAYRAM
Heat Stress, Kidney Injury
Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?
Severe heat strain arising from intense physical work under climate conditions that does not allow sufficient heat dissipation may lead to heat stroke.
- Trial name
- NCT04985292
- Testing
- Probiotic, Lactobacillus
- Where
- Sweden
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Autism Spectrum Disorders
Intestinal Permeability in Children With Autism Spectrum Disorder
In recent years, increasing attention has been directed toward the role of the gut-brain axis in the pathogenesis of neurodevelopmental disorders, particularly Autism Spectrum Disorder (ASD).
- Trial name
- IP-ASD (NCT07032857)
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- University of Bari
Peanut Allergy, Nut Allergy
Immune-supportive Diet and Gut Permeability in Allergic Children
Peanut and nut allergy can be life threatening. Some patients have very low threshold levels (i.e. the amounts of peanut and nuts to which the patients react), others react to higher doses.
- Trial name
- DIAMETER (NCT05667610)
- Testing
- Immune-supportive diet, Standard care
- Where
- Netherlands
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Microscopic Colitis
Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis
Medication use, especially NSAIDs and PPIs, prior to diagnosis is considered a risk factor for MC development. However, the exact pathophysiological mechanism is unclear.
- Trial name
- NCT02303132
- Testing
- Ussing experiment
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gut Health, Metabolic Health
Food Additives - Do Processed Diets Impact on Gut and Metabolic Health
This dietary intervention study will assess the effect in healthy human volunteers of an E number which is a food additive and commonly used and consumed emulsifier, on gut function, gut inflammation and glucose metabolism.
- Trial name
- FADiets (NCT03842514)
- Testing
- Soya lecithin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Impaired Small Intestinal Permeability
Performance of 13C Mannitol for in Vivo Measurement of Small Intestinal Permeability
The investigators' overall objective with this study is to determine performance characteristics of small intestine permeability measurement using 13C mannitol and 12C (regular) mannitol.
- Trial name
- NCT02603822
- Testing
- 12C mannitol, Indomethacin, 13C mannitol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcoholic Liver Disease
Alcohol, Gut Leakiness, & Liver Disease
The goal of this study is to investigate the role of gut leakiness in alcoholic liver disease. Gut leakiness may be the missing susceptibility factor that explains why some alcoholics develop liver disease and others don't.
- Trial name
- NCT05428072
- Testing
- Sugar test, Aspirin Challenge
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Celiac Disease, Wheat Hypersensitivity
Changes in Intestinal Permeability 4 Hours After Gluten Challenge
This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.
- Conditions
- Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy
- Trial name
- NCT03288831
- Testing
- Gluten
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation
Fungal Fiber for Gut Health
This study compares effects of plant based fiber vs fungi based fiber on clinical outcomes related to gut function (immunity, emotions, stress) and explores the role of gut microbiome structure and function on individual…
- Conditions
- Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation, Stress, Gut Health
- Trial name
- FUN4GUT (NCT06404749)
- Testing
- fungal fiber, inulin
- Where
- Argentina
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Future Biome SA
Crohn's Disease, Short Bowel Syndrome
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Crohn's Disease, Short Bowel Syndrome, Malabsorption Syndromes, Celiac Disease
- Trial name
- NCT00138879
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St Mark's Hospital Foundation
Crohn's Disease
Effect of Glutamine on Intestinal Permeability in Crohn's Disease
The purpose of this study is to see whether enteral glutamine supplementation improves intestinal permeability and small intestinal morphology in patients with Crohn's disease.
- Trial name
- NCT00838149
- Testing
- Glutamine, Whey protein
- Where
- India
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Exercise and Gut-derived Phenolics
Flavonoids, Exercise, Gut-Derived Phenolics
PURPOSE: 1. PRIMARY: Using a randomized, parallel group design, this investigation will determine if the combination of 2-weeks polyphenol supplementation (using the Reoxcyn flavonoid supplement in capsule form) and one acute…
- Trial name
- NCT03249571
- Testing
- Flavonoid supplement
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Appalachian State University