Clinical trials: Intestinal Permeability
Healthy Participants
Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.
Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to…
- Trial name
- NCT07650058
- Testing
- High-Glycemic Breakfast Containing Cereal and Fresh Mango, High-Glycemic Breakfast Containing Cereal and Table Sugar
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ball State University
Crohn Disease
Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability
The objectives of the study are to evaluate the safety and tolerability of oral administration of MB-102, and to evaluate the use of MB-102 as a means of measuring gut permeability in normal participants (n=10) and in those with…
- Trial name
- NCT03962998
- Testing
- Lactulose/Rhamnose solution, MB-102
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Allergic Rhinitis (AR)
EFFECT OF AYURVEDA TREATMENT IN ALLERGIC RHINITIS
Background Allergic Rhinitis is a chronic Th2-mediated inflammatory disorder associated with significant disease burden and impaired quality of life.
- Trial name
- ARAM (NCT07626099)
- Testing
- AYURVEDA treatment protocol, Control(Citrizine 10mg)
- Volunteers
- 104 people
- Sponsor
- Amrita Vishwa Vidyapeetham
Prebiotics, Aged
Prebiotic Supplementation and Intestinal Barrier Function in Elderly: a RCT
The investigators aim was to assess whether 6 weeks of oral intake of the wheat-derived prebiotic fiber arabinoxylan or oat-derived beta-glucan could improve intestinal barrier function against drug-induced barrier disruption in…
- Trial name
- NCT03336385
- Testing
- Naxus, Oatwell
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Intestinal Permeability, Immune Response
Fructose and (Aging)
The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals
- Trial name
- FRUage (NCT07757347)
- Testing
- Fructose, Glucose
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Crohn's Disease
Effect of Glutamine on Intestinal Permeability in Crohn's Disease
The purpose of this study is to see whether enteral glutamine supplementation improves intestinal permeability and small intestinal morphology in patients with Crohn's disease.
- Trial name
- NCT00838149
- Testing
- Glutamine, Whey protein
- Where
- India
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Inflammation, Sarcopenia
From the Gut to the Strut: Reducing Inflammation for Healthy Muscles
This research aims to evaluate the effectiveness of a dietary supplement on reducing inflammation and improving muscle health. The product is a food supplement notified to the Ministry of Health consisting of…
- Conditions
- Inflammation, Sarcopenia, Gut Permeability
- Trial name
- NCT05730985
- Testing
- Miotrof® formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Obesity, Circadian Dysregulation
Impact of Blueberry Consumption on Gastrointestinal Health
This study will evaluate the impact of blueberry consumption on markers of gastrointestinal health including gut microbiota, intestinal permeability, and gut-derived inflammation in those vulnerable to a unhealthy gut milieu.
- Trial name
- NCT03934177
- Testing
- Blueberry powder
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Aging, Diet, Healthy
Western Diet on Cardiometabolic and Immune Function
This study will implement a Western Diet (WD) to understand cardiometabolic and immune function in middle-aged adults (50- 64 years old).
- Trial name
- WD (NCT06528977)
- Testing
- Western Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Inflammation
Impact of JuicePlus+ on the Health Status of an Overweight Stressed Population
The purpose of this study is to determine if a dried fruit and vegetable supplement (Juice Plus+) can alter the gut microbiome and improve gut permeability and inflammatory levels in an obese, stressed population.
- Trial name
- NCT02512107
- Testing
- Juice Plus+
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Celiac Disease
Effects of a Nutritional Solution to Improve Intestinal Permeability in Celiac Patients
Celiac disease (or gluten intolerance) is recognized as one of the most common chronic diseases: prevalence of 1 in 100 to 1/300 people in Europe and the United States.
- Trial name
- Protalsafe (NCT03483805)
- Testing
- Protalsafe
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Société Guaranteed Gluten Free (GGF)
Endothelial Dysfunction, Mood Disorders
Relative Energy Deficiency in Rowers
This study aims to learn about relative energy deficiency in male and female rowers at the end of the direct sport preparation phase of the annual training cycle.
- Conditions
- Endothelial Dysfunction, Mood Disorders, Malnutrition, Calorie
- Trial name
- NCT06452758
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Poznan University of Physical Education
Optic Neuritis, Multiple Sclerosis
The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS
Disruption of the blood brain barrier (BBB) is associated with inflammatory conditions of the central nervous system (CNS). This clinical trial aims to investigate whether following a gluten-free diet (GFD) for six months can…
- Conditions
- Optic Neuritis, Multiple Sclerosis, Clinically Isolated Syndrome
- Trial name
- NCT03451955
- Testing
- Gluten-free diet
- Where
- 2 sites in Denmark
- Volunteers
- 103 people
- Sponsor
- University of Copenhagen
Short Bowel Syndrome
rHGH and Intestinal Permeability in Intestinal Failure
Patients who are being asked to participate in this study have a short small bowel and will be prescribed to take the medication: Zorbtive® ("Zorbtive/Somatropin/(rHGH)").
- Trial name
- rHGH (NCT01380366)
- Testing
- Somatropin, Seven Day Food Diary, Blood Tests (standard of care)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Infertility Female, Zonulin
Effect Of The Mediterranean Diet On Zonulin And Infertility
The goal of this clinical trial is to learn if mediterranean diet works to treat infertility in women. It will also learn about the initial and end of study zonulin levels of mediterranean diet and control group.
- Conditions
- Infertility Female, Zonulin, Intestinal Permeability, Mediterranean Diet
- Trial name
- NCT07072936
- Testing
- mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- SINEM BAYRAM
Combat Training Stress
Changes in the Permeability of the Blood Brain Barrier and Intestinal Barrier in Humans During Conditions of Stress and Immune Activation: in Vivo Studies
The relevance of BBB and IB permeability changes as a major precipitating cause for cognitive and digestive dysfunction in the military stress setting.
- Trial name
- NCT01417416
- Sponsor
- National University Hospital, Singapore
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis), NON-IBD
AI-Enhanced Wide-Field Endoscopic Fluorescence Mapping of Gastrointestinal Mucosal Permeability in IBD - A Pilot Study in IBD Patients and Controls
This pilot study will test a new imaging system that uses fluorescent dye and artificial intelligence (AI) during colonoscopy to measure how "leaky" the lining of the colon is in people with inflammatory bowel disease (IBD).
- Trial name
- NCT07546955
- Testing
- Artificial Intelligence-Enhanced Wide-Field Mucosal Permeability Mapping
- Volunteers
- 70 people
- Sponsor
- Hamilton Health Sciences Corporation
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Functional Dyspepsia
A Study of Glutamine to Treat Intestinal Permeability in Functional Dyspepsia
The purpose of this research is to collect data from patients diagnosed with functional dyspepsia who are treated with glutamine and describe safety and treatment results compared to patients taking a placebo.
- Trial name
- NCT05655819
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- David J. Cangemi