Clinical trials: Intestinal Permeability
Intestinal Permeability, Immune Response
Fructose and (Aging)
The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals
- Trial name
- FRUage (NCT07757347)
- Testing
- Fructose, Glucose
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Inflammation, Vaccine
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
The purpose of this study is to determine if adding dietary fiber, such as inulin, to a diet that does not have enough fiber would raise the levels of potentially beneficial bacteria, such as Bifidobacterium, in the gut.
- Conditions
- Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
- Trial name
- NCT04543877
- Testing
- Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Intestinal Permeability, Inflammation
Induction of Gut Permeability by an Oral Vaccine
This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system.
- Conditions
- Intestinal Permeability, Inflammation, Vaccine, Typhoid Fever
- Trial name
- NCT04083950
- Testing
- Vivotif Typhoid Oral Vaccine, Aspirin (Positive Control)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Intestinal Permeability
Establishing and Validating a Meal-provoked Intestinal Permeability Test for Nutritional and Metabolic Health Clinical Research.
Development of Intestinal Permeability Tests for Clinical Nutrition and Metabolic Health Studies
- Trial name
- Gut-Perm (NCT07066176)
- Testing
- Aspirin, Mixed meal beverage
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Laval University
Infertility Female, Zonulin
Effect Of The Mediterranean Diet On Zonulin And Infertility
The goal of this clinical trial is to learn if mediterranean diet works to treat infertility in women. It will also learn about the initial and end of study zonulin levels of mediterranean diet and control group.
- Conditions
- Infertility Female, Zonulin, Intestinal Permeability, Mediterranean Diet
- Trial name
- NCT07072936
- Testing
- mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- SINEM BAYRAM
Intestinal Permeability, Leaky Gut Syndrome
Dietary Supplements for Reduction of Intestinal Permeability Levels
A randomised and controlled trial, in which the effect of a dietary supplement is evaluated for reduction of intestinal permeability levels of subjects with high levels of zonulin in feces
- Conditions
- Intestinal Permeability, Leaky Gut Syndrome, Zonulin
- Trial name
- permeability (NCT06760377)
- Testing
- Dietary supplement Group
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Intestinal Permeability
Dietary Supplementation on Gastrointestinal Barrier Function
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels on parameters of gastrointestinal (GI) health in otherwise generally healthy…
- Trial name
- NCT06262880
- Testing
- plant derived phenolics, Microcrystaline cellulose (MCC)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Brightseed
Focus: Simplified Method to Assess Intestinal Permeability
Biomarkers for Intestinal Permeability
This study aims to find easy-to-measure biomarkers of intestinal permeability as surrogate markers for effortful "gold standard" methods.
- Trial name
- NCT04667208
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Intestinal Permeability, Gastrointestinal Function
The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults
In this double blind, crossover study participants will consume a cranberry beverage and a cranberry-flavored beverage for 2 weeks each. Gut permeability will be assessed weekly using aspirin and food-grade sugar molecules.
- Trial name
- MAC (NCT03957239)
- Testing
- Cranberry Beverage, Control Beverage
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Florida
Impaired Small Intestinal Permeability
Performance of 13C Mannitol for in Vivo Measurement of Small Intestinal Permeability
The investigators' overall objective with this study is to determine performance characteristics of small intestine permeability measurement using 13C mannitol and 12C (regular) mannitol.
- Trial name
- NCT02603822
- Testing
- 12C mannitol, Indomethacin, 13C mannitol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Intestinal Permeability
The Effect of Probiotic Intervention on Intestinal Permeability
This trial is a single-site, randomised, double blind, placebo-controlled, two-armed parallel-group trial in healthy adult volunteers.
- Trial name
- NCT03027583
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Low-grade Inflammation, Increased Intestinal Permeability
Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly
The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month.
- Trial name
- NCT02342496
- Testing
- Active, only probiotics, Active, blend of berries and probiotics
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Probi AB
Low-grade Chronic Inflammation, Intestinal Permeability
Diet and Systemic Inflammation
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes.
- Conditions
- Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease
- Trial name
- DASI (NCT01424306)
- Testing
- Fructose-sweetened beverages, Glucose-sweetened beverages, High-fructose corn syrup-sweetened beverages
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Vitamin D Deficiency, Obesity
Vitamin D and Adipose Tissue Inflammation
Chronic, low-grade adipose tissue inflammation is a major risk factor for type 2 diabetes mellitus. The cause of adipose tissue inflammation has remained largely unclear.
- Conditions
- Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
- Trial name
- NCT01477034
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Intestinal Permeability, Challenge Test
Intestinal Barrier Function and Probiotics.
Rationale: Enterotoxigenic Escherichia coli (ETEC) bacteria adhere to the mucosa of the proximal intestines. There it produces an toxin which presents a local and relevant challenge to the intestines.
- Conditions
- Intestinal Permeability, Challenge Test, Intestinal Health, Inflammation
- Trial name
- NCT01241201
- Testing
- Priobiotic supplement VSL#3
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TNO
Intestinal Permeability
Intestinal Permeability
Rationale: Intestinal permeability of subjects can vary depending on their health status. It is therefore important to be able to measure and quantify intestinal permeability in a standardized way.
- Trial name
- NCT01049386
- Testing
- No intervention, Sugar absorption test
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TNO