Clinical trials: Intestinal Obstruction
Bowel Obstruction
A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy
This study is designed to compare the standard of care against EXPAREL (bupivacaine liposome injectable suspension) to determine if total opioid consumption is reduced when using EXPAREL, therefore possibly reducing total…
- Trial name
- IMPROVE-Lap (NCT02058290)
- Testing
- IV morphine sulfate or Sponsor-approved equivalent, EXPAREL
- Where
- 6 sites in United States
- Volunteers
- 122 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Ileus
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/ Postoperative Ileus
Patients undergoing major abdominal surgery are at highest risk for developing postoperative ileus (POI), occurring in nearly all cases.
- Trial name
- NCT00388479
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 666 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Nasal Congestion, Lung Infection
Biomarker for Cystic Fibrosis
International, multicenter, observational, longitudinal study to identify biomarker/s for Cystic fibrosis and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s
- Conditions
- Chronic Nasal Congestion, Lung Infection, Breathlessness, Clubbing Toes
- Trial name
- BioCyFi (NCT02710383)
- Where
- 5 sites in Albania, Georgia and 3 more
- Volunteers
- 54 people
- Sponsor
- CENTOGENE GmbH Rostock
Gastroschisis, Bowel Obstruction
The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients.
This study will investigate the use of a drug called Gastrografin to aid in bowel mobility for paediatric patients who have undergone gastroschisis surgery.
- Conditions
- Gastroschisis, Bowel Obstruction, Birth Defect
- Trial name
- NCT03334578
- Testing
- Gastrografin
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Ogilvie Syndrome
Neostigmine Route for Acute Colonic Pseudo Obstruction
Neostigmine is commonly used for medical treatment of acute colonic pseudo obstruction, however, the ideal route of administration has not been determined.
- Trial name
- NCT04951726
- Testing
- Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Southern California
Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
S1316, Surgery or Non-Surgical Management in Treating Patients With Intra-Abdominal Cancer and Bowel Obstruction
This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction.
- Trial name
- NCT02270450
- Testing
- therapeutic conventional surgery, gastrointestinal complications management/prevention, quality-of-life assessment
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 221 people
- Sponsor
- SWOG Cancer Research Network
Resolution of Bowel Obstruction
The Application of Ultrasound in the Evaluation of Patients With Colon Cancer-related Obstruction Receiving Colonic Stent Placement
Bowel ultrasound may serve as a diagnostic tool to detect the resolution of bowel obstruction. In this study, we aim to validate the use of bowel ultrasound to evaluate patients with colon obstruction receiving colonic stents at…
- Trial name
- NCT06997848
- Testing
- colonic stent
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Small Bowel Obstruction, Intestinal Obstruction and Ileus
The Effect of Nasogastric Tube Placement on Complications in Patients With Small Bowel Obstruction - the SBO-TUBE Trial
Background: Small bowel obstruction (SBO) is a surgical emergency where the normal continuous bowel movements are hindered and approximately 8000-9000 patients visit the emergency department every year in Sweden due to SBO.
- Trial name
- SBO-TUBE (NCT07574515)
- Testing
- Nasogastric tube placement
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Linkoeping
Small Bowel Obstruction, Small Bowel Adhesion
Comparison of Early Operative Treatment and 48 h Conservative Treatment in Small Bowel Obstruction
This study will compare the results of early surgery after 12 h conservative treatment and 48 h conservative treatment of adhesive small bowel obstruction.
- Conditions
- Small Bowel Obstruction, Small Bowel Adhesion, Strangulation of Ileum
- Trial name
- COTACSO (NCT03139149)
- Testing
- Adhesiolysis, X-ray diagnostics, Computer tomography
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Hemorrhoidectomy, Pudendal Nerve
IntraopeRativE Use of periNeal Block for Hemorrhoidectomy
Perineal block with the anesthesia of the pudendal nerve's terminal branches allows to perform a hemorrhoidectomy with the optimal intraoperative and postoperative analgesia The purpose of this study is to assess the…
- Trial name
- IREN (NCT04288349)
- Testing
- perineal block with usage of one of solutions, epinephrine + ropivacaine +saline, epinephrine + saline
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Russian Society of Colorectal Surgeons
Gastric Outlet Obstruction, Rectocele
RCT: STARR vs Biofeedback
This study aimed to evaluate the safety and symptomatic outcomes achieved with Stapled Transanal Rectal Resection (STARR) compared to biofeedback training in patients with obstructed defecation syndrome (ODS).
- Conditions
- Gastric Outlet Obstruction, Rectocele, Intussusception, Anismus
- Trial name
- ODS II (NCT00556283)
- Testing
- STARR, Biofeedback
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 121 people
- Sponsor
- Ethicon Endo-Surgery (Europe) GmbH
Paralytic Ileus, Critically Ill
Efficacy of PRUcalopride in Critically Ill Patients With Paralytic ILeus
Paralytic ileus is a common intestinal dysfunction in critically ill patients. There are still no established the effective medications except correcting the primary causes and prokinetics trial which limited in efficacy and…
- Trial name
- EPRUCIL (NCT04190173)
- Testing
- Prucalopride
- Where
- Thailand
- Volunteers
- 62 people
- Sponsor
- Prince of Songkla University
Malignant Intestinal Obstruction
Efficacy and Safety of Lanreotide 120 Milligram (mg) as a Palliative Treatment of Clinical Symptoms Associated With Malignant Intestinal Obstruction in Inoperable Patients
The primary objective of this study is to assess the efficacy of Lanreotide 120 mg for the relief of clinical symptoms due to malignant bowel obstruction in inoperable patients.
- Trial name
- NCT01076803
- Testing
- Lanreotide (acetate)
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Bowel Obstruction, Bowel Ischemia
Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses
In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at two to three time points during procedures of…
- Conditions
- Bowel Obstruction, Bowel Ischemia, Diverticulitis, Abnormality of the Gastrointestinal Tract
- Trial name
- NCT04709445
- Testing
- ICG-NIRF Imaging plus ingress and egress analysis
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Catheter-related Bloodstream Infection (CRBSI) Nos
Clinical Trial Comparing Catheter Lock Solutions TaurolockTMHep 100 and Heparin 100 IE/ml.
The purpose of the investigation is to compare two catheter lock solutions (TaurolockTMHep100 and Heparin 100 IE/ml), on the occurence of catheter related blood stream infection, in patients with intestinal failure and a central…
- Trial name
- NCT01948245
- Testing
- TaurolockTMHep100, Heparin 100 IE/ml
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Palle Bekker Jeppesen
Colorectal Obstruction, Left Colonic Adenocarcinoma
Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A Randomized, Controlled Study
To evaluate wether colorectal stenting carry a significant clinical advantage
- Trial name
- NCT00514332
- Testing
- stent
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Ileus, Bowel Obstruction
Stoma Tube Decompression and Postoperative Ileus After Major Colorectal Surgery
Postoperative ileus is common after colorectal surgery, occurring in up to 20% of patients. Stomas are frequently created in conjunction with major colorectal surgery.
- Trial name
- NCT01911793
- Testing
- Stoma Tube
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer, Neoadjuvant Chemotherapy
Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer
Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity…
- Conditions
- Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
- Trial name
- NACSOC-02 (NCT05202314)
- Testing
- Immunotherapy (Camrelizumab)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Chao Yang Hospital
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen
Small Bowel Obstruction
Value of CT-Scan and Oral Gastrografin in the Management of Post Operative Small Bowel Obstruction
Small bowel obstructions are responsible for 2 to 5% of emergency hospital admissions and 20% of all emergency surgical procedures.
- Trial name
- NCT00389116
- Testing
- gastrograffin, water
- Where
- France
- Volunteers
- 242 people
- Sponsor
- University Hospital, Rouen