Clinical trials: Intestinal Obstruction
Hernia, Inguinal, Postoperative Pain
Comparison of Hernia Sac Ligation Versus Invagination
Management of indirect hernial sac in inguinal hernia repairs has long been a subject of debate among general surgeons. Although hernial sac high ligation (HL) is a time-honored concept in groin hernia surgery…
- Conditions
- Hernia, Inguinal, Postoperative Pain, Recurrence
- Trial name
- NCT05308251
- Testing
- Lichtenstein Mesh Hernioplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Samsun Education and Research Hospital
Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain
RATIONALE: Naloxone may be effective in treating constipation that may be caused by opioid pain medications such as morphine. PURPOSE: Phase III trial to determine the effectiveness of naloxone in relieving constiption in…
- Trial name
- NCT00020605
- Testing
- naloxone hydrochloride
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Small Bowel Obstruction
A Study of Intravenous Acetaminophen for Small Bowel Obstruction
The purpose of this study is to compare IV Acetaminophen for pain control to the usual care with opioids in patients admitted for small bowel obstruction.
- Trial name
- NCT05878015
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Colorectal Cancer, Bowel Obstruction
Endolaparoscopic Versus Immediate Surgery for Obstructing Colorectal Cancers
The aim of this study is to compare the stoma rate, clinical efficacy, and safety of patients treated by endoscopic stenting followed by elective laparoscopic resection (the 'endolaparoscopic approach') versus immediate emergency…
- Trial name
- NCT00164879
- Testing
- Endoscopic stenting followed by elective laparoscopic resection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Small Bowel Obstruction
Identifying the Effect of Somatostatin Treatment in Early Postoperative Simple Small Bowel Obstruction
Primary Objective: To demonstrate whether an early fixed Somatostatin treatment improves the complete recovery rate of early postoperative simple small bowel obstruction (EPSSBO) compared with the common daily practice Notes: 1.
- Trial name
- NCT01082627
- Testing
- Somatostatin, common daily practice
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Nanjing PLA General Hospital
Pathology, Sigmoid Volvulus
Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus
Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with…
- Conditions
- Pathology, Sigmoid Volvulus, Hypoganglionosis
- Trial name
- NCT04363125
- Testing
- Pathology result
- Where
- Turkey (Türkiye)
- Volunteers
- 310 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Intestinal Obstruction
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and…
- Trial name
- NCT01596764
- Testing
- Loperamide, Colon Transit, Sulfasalazine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Failure to Thrive, Nutritional Deficiency
Nasogastric Tube Securement Comparison Study
This study evaluates the use of tape to secure nasogastric tubes compared to securement with a nasal bridle device.
- Conditions
- Failure to Thrive, Nutritional Deficiency, Constipation, Bowel Obstruction
- Trial name
- NTSNB (NCT03202576)
- Testing
- Nasal Bridle
- Volunteers
- 43 people
- Sponsor
- University of Colorado, Denver
Bowel Ileus, Cesarean Section Complications
Effect of Chewing Gum and Drinking Fennel Tea
Aim: Postoperative ileus after cesarean section is a problem that significantly prolongs hospital stay and increases perioperative costs.
- Trial name
- NCT06403215
- Testing
- Chewing gum group, Fennel tea group, Chewing gum+Fennel tea group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Marmara University
Chronic Intestinal Pseudo-Obstruction
Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)
This study was designed to investigate the clinical safety, tolerability and efficacy of prucalopride in improving the symptoms associated with chronic intestinal pseudo-obstruction (CIP) in subjects with CIP.
- Trial name
- NCT00793247
- Testing
- PRU-PLA-PRU-PLA, PLA-PRU-PLA-PRU, PLA-PRU-PRU-PLA
- Where
- United Kingdom
- Sponsor
- Movetis
Ileus
Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC
The purpose of this study is to investigate the ability of alvimopan to reduce the time to return of bowel function in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
- Trial name
- ILEUS (NCT03352414)
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of California, San Diego
Colorectal Cancer
Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block
Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.
- Trial name
- NCT03803267
- Testing
- Erector spinae plane block, Quadratus lumborum block, Propofol
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University
Intestinal Obstruction
Prospective Multicenter Validation of a Severity Score of Strangulated Small Bowel Occlusion
The purpose of this study is to apply and validate a clinicoradiological score for the prediction of severity of strangulated small bowel occlusion (SBO).
- Trial name
- NCT01125280
- Testing
- Conservative treatment versus surgical treatment
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Geneva
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Colorectal Cancer, Colorectal Neoplasms
The Effectiveness of Bupivacaine and Bupivacaine+Dexmedetomidine Combination in Transversus Abdominis Plane* Block
Transversus abdominis plane (TAP) block is an anesthesia method that provides somatic analgesia to the anterior and lateral abdominal walls.
- Trial name
- TAP (NCT06370949)
- Testing
- Bupivacain, bupivacain+dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Colon Cancer, Rectal Cancer
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the…
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- TAP (NCT02591407)
- Testing
- TAP Block, Continuous Epidural Analgesia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Trinity Health Michigan
Postoperative Ileus.
Does Sugared or Sugar Free Chewing Gum Reduces Postoperative Ileus After Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is now very common procedure to remove the gall bladder from abdomen. After this procedure many patients suffer from the non functioning of intestine and stomach which is very common after any…
- Trial name
- NCT02162134
- Testing
- sugar free chewing gum, sugared chewing gum, Tab. Midazolam 7.5 mg
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi
Irritable Bowel Syndrome
Efficacy, Safety, and Tolerability of JNJ-27018966 (Eluxadoline) in the Treatment of Irritable Bowel Syndrome With Diarrhea
The purpose of this study is to determine the efficacy, safety, and tolerability of different doses of JNJ-27018966 (eluxadoline) compared with placebo in the treatment of patients with irritable bowel syndrome with diarrhea…
- Trial name
- NCT01130272
- Testing
- Eluxadoline
- Where
- 288 sites in United States
- Volunteers
- 807 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Pain, Acute Post-Operative, Pilonidal Sinus
Effect of Sacral Erector Spinae Plane Block on Hemorrhoid and Pilonidal Sinus Surgery
Introduction: This study investigated the efficacy of sacral erector spinae plane block (ESPB) for managing postoperative pain and reducing opioid consumption in patients undergoing hemorrhoid and pilonidal sinus (PS) surgery.
- Conditions
- Pain, Acute Post-Operative, Pilonidal Sinus, Hemorrhoids, Anesthesia
- Trial name
- NCT06459739
- Testing
- sacral ESPB
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Erzincan Binali Yildirim Universitesi