Clinical trials: Intestinal Microbiome
People With High Body Fat Percentage, People With High Visceral Fat Area
Effects of Barley Green on Visceral Fat Area in the Human Body and Investigation Into the Associated Mechanism of Intestinal Microbiota
The aim of this study was to investigate the changes in visceral fat area and associated indicators in individuals with high body fat percentage under the intervention of barley green, elucidate the clinical efficacy of barley…
- Trial name
- NCT06886048
- Testing
- barley green
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University People's Hospital
Acute Pancreatitis, 2019 Novel Coronavirus Infection
Study and Analysis of Acute Pancreatitis Complicated With COVID-19
The goal of this observational study was to explore the complex relationship between changes in the intestinal microbiome and serum metabolites in patients with novel coronavirus infection and acute pancreatitis.
- Trial name
- NCT05722678
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yuansong Sun
Rectal Cancer, Low Anterior Resection Syndrome
Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer
This prospective, single-center, single-arm, open-label clinical study aims to evaluate whether autologous fecal microbiota transplantation can improve bowel and anal function after ileostomy reversal in patients with rectal…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis
- Trial name
- NCT07711509
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Depression, Depression Disorder
GynMDD Add-On to Supportive Psychotherapy in Mild to Moderate Depression
The goal of this clinical trial is to learn whether the dietary supplement GynMDD, when taken as an add-on to supportive psychotherapy, can improve symptoms of mild to moderate depression in adults aged 18 to 65.
- Conditions
- Depression, Depression Disorder, Depression in Adults
- Trial name
- SWING (NCT07416747)
- Testing
- GynMDD
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Fondation FondaMental
Liver Cirrhosis
Compositional Shift of Gut Microbiome According to the Complications in Patients With Liver Cirrhosis
Change in gut microbiome is closely associated with liver cirrhosis diseases initiation, progression, establishment, and severity.
- Trial name
- NCT05786755
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Breastfeeding
Effects of 5-Methyltetrahydrofolic Acid Supplementation on Maternal Health and One-Carbon Metabolism During Lactation
This double-blind, randomized, placebo-controlled parallel trial evaluates the effects of maternal 5-methyltetrahydrofolate (5-MTHF) supplementation during breastfeeding.
- Trial name
- OCMS (NCT07508917)
- Testing
- 5-MTHF Supplementation
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Fundació Sant Joan de Déu
Perioperative Neurocognitive Disorders, Gastric Cancer
Effect of Gastrectomy on Gut Microbiome and Cognitive Function
Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years.
- Trial name
- NCT06186089
- Testing
- probiotics
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Jiangjiang Bi
Prematurity, Low Birth Weight Neonates
Metagenomic & Metabolomic Study: Bifidobacterium Probiotic Effects on Gut Microbiota & SCFA in Preterm NICU Infants
One million premature babies die due to prematurity complications, contributing the most to the causes of death in children under 5 years old.
- Trial name
- NCT07213414
- Testing
- Probiotics
- Where
- 3 sites in Indonesia
- Volunteers
- 72 people
- Sponsor
- Hasanuddin University
Type 2 Diabetes Mellitus (T2DM)
Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes
This clinical trial investigates the short-term effects of two commonly used non-nutritive sweeteners (NNS), saccharin and sucralose, on blood glucose regulation and the gut microbiota in adults with Type 2 Diabetes Mellitus…
- Trial name
- NCT07124585
- Testing
- Sucralose, Saccharin
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- National University of Malaysia
Gut Microbiota, Metabolic Syndrome
Effect of Raspberry on Gut Microbiota and Metabolic Syndrome
There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health.
- Trial name
- NCT03620617
- Testing
- Raspberry supplement
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Laval University
To Search for Biomarkers Associated With Ischemic Heart Failure, To Explore the Relationship Between Intestinal Flora and Ischemic Heart Failure
Correlation of Intestinal Flora and Metabolomics in Patients With Ischemic Heart Failure
To provide new ideas for the treatment of patients with ischemic heart failure, this study is to search for differential metabolic markers associated with ischemic heart failure and to study the influence of fecal flora on the…
- Trial name
- NCT04962763
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Inflammation, Microbiota
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
This proposal will quantify dietary exposure of a nano- food additive in the U.S. food supply, and determine its impact on the human gut microbiome, gut inflammation, permeability and oxidative stress.
- Conditions
- Inflammation, Microbiota, Gastrointestinal Irritation
- Trial name
- NCT05864352
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Lowell
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Obesity
ACE Stapler Sub Study
Obesity and its associated conditions have reached epidemic proportions. Estimates are that about one third of the adults in the United States have obesity.
- Trial name
- NCT02381340
- Testing
- ACE stapling procedure
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Gastrointestinal Microbiome (Focus), Gastrointestinal Symptoms
The Effect of a Synbiotic on Intestinal Barrier Function and Microbiota Modulation in Middle-aged to Elderly Individuals With Excessive Body Weight
The study is a single-center, randomized, double-blind, placebo-controlled study in middle-aged to elderly adults with excessive body weight. The study includes an 8-week intervention period followed by a 2-week follow-up period.
- Trial name
- myBIOM (NCT07453823)
- Testing
- Synbiotic
- Where
- Ireland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chr Hansen - part of Novonesis
Inflammatory Bowel Diseases
Fecal Microbiota Transplantation and Analysis of Fecal Microbiome in IBD Patients
Fecal microbiome of donor and recipient will be analyzed before and after fecal microbiota transplantation in IBD patients.
- Trial name
- NCT03399188
- Testing
- Fecal microbiome transplantation
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Intestinal Microbiota Between Different Groups
Study of the Intestinal Microbiota
The intestinal microbiota is the set of numerous microorganisms (between 1012 and 1014 bacteria, viruses, parasites, and non-pathogenic fungi) that live in our digestive tract, mainly in the small intestine and colon.
- Trial name
- NEUROBIOTE (NCT07058961)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Cows Milk Allergy
Synbiotics Cohort Study
Observational study exploring the clinical outcomes of infants with cow's milk allergy who are prescribed a hypoallergenic formula containing synbiotics.
- Trial name
- NCT05046418
- Testing
- Hypoallergenic formula containing synbiotics
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Nutricia UK Ltd
Anorexia Nervosa, Dysbiosis
Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment…
- Conditions
- Anorexia Nervosa, Dysbiosis, Anxious Depression
- Trial name
- INT-METAVOSA (NCT05632497)
- Testing
- Stool and blood samples
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris