Clinical trials: Intestinal Metaplasia
Gastric Intestinal Metaplasia
I-scan With Magnification for the Detection of Gastric Intestinal Metaplasia
The purpose of this study is to assess whether i-scan with magnification can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT02516735
- Testing
- I-scan with magnification, Standard endoscopy
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Shandong University
STOMACH NEOPLASM
Use of Pyrvinium to Reverse Stomach Precancerous Conditions
This study is carried out to find out if a drug called pyrvinium is able to convert pre-cancerous tissue in the stomach back to healthy tissue, to lower the chances of stomach cancer.
- Trial name
- NCT06782048
- Testing
- Pyrvinium, Blood biomarkers analyses, Oesophagogastroduodenoscopy (OGD) and biopsy
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University Hospital, Singapore
Barrett's Esophagus, Intestinal Metaplasia
Is the Neosquamous Epithelium "Normal" Following Endoscopic Ablation of Dysplastic Barrett's Esophagus?
The investigators propose a study comparing the morphological and functional aspects of the neosquamous epithelium (NSE) after ablative therapy for dysplastic Barrett's esophagus (BE) to that of native squamous epithelium in…
- Conditions
- Barrett's Esophagus, Intestinal Metaplasia, Gastroesophageal Reflux Disease (GERD)
- Trial name
- NCT01373125
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett's Esophagus
Effect of Dexlansoprazole 60 mg QD and 60 mg BID on Recurrence of Intestinal Metaplasia in Subjects Who Have Achieved Complete Eradication of Barrett's Esophagus With Radiofrequency Ablation
This study is designed to evaluate the effect of dexlansoprazole once daily (QD) and twice daily (BID) dosing on the recurrence of intestinal metaplasia (IM) in participants who achieved complete eradication of Barrett's…
- Trial name
- NCT02162758
- Testing
- Dexlansoprazole
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Takeda
Barretts Esophagus With Low Grade Dysplasia, Dysplasia
Acetic Acid for the Detection of Esophageal Neoplasms
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease that occurs in up to 10% to 15% of patients with this pathology.
- Conditions
- Barretts Esophagus With Low Grade Dysplasia, Dysplasia, Intestinal Metaplasia
- Trial name
- NCT04054713
- Testing
- Acetic acid chromoendoscopy, Seattle protocol
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Barrett Esophagus, Intestinal Metaplasia
Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)
A multicenter, prospective, single arm, non randomized clinical trial to evaluate the safety and efficacy of the C2 CryoBalloon Focal Ablation System (CbFAS) for the treatment of persistent dysplasia or intestinal metaplasia (IM)…
- Conditions
- Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
- Trial name
- NO FEAR-BE (NCT03554356)
- Testing
- CryoBalloon Focal Ablation System
- Where
- 11 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Mucosal Microbiome, Gastric Intestinal Metaplasia
Mucosal Microbiome in Human Gastric Intestinal Metaplasia and Duodenal Tissue.
To investigate the mucosal microbiome in human gastric intestinal etaplasia and duodenal tissue.
- Conditions
- Mucosal Microbiome, Gastric Intestinal Metaplasia, Duodenum
- Trial name
- NCT02428426
- Testing
- endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shandong University
Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence
Validation the Artificial Intelligence System for Automatic Evaluation of the Extent of Intestinal Metaplasia
The operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems using biopsy specimens were commonly used for histological assessment of gastric cancer risk.
- Conditions
- Intestinal Metaplasia of Gastric Mucosa, Artificial Intelligence, Endoscopy
- Trial name
- NCT05464108
- Testing
- The diagnosis of Artificial Intelligence and endosopists
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Chronic Gastritis
UC Davis Cohort of Pre-Malignant and Malignant Gastro-Intestinal DisEases Study
The UC Davis Cohort of Pre-Malignant and Malignant GastroIntestinal DisEases (TUMMIE) Study is a prospective longitudinal cohort study designed to improve understanding of the natural history, risk factors, and biological…
- Conditions
- Intestinal Metaplasia, Chronic Gastritis, Atrophic Gastritis, Autoimmune Gastritis
- Trial name
- TUMMIE (NCT05021029)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, Davis
Gastric Intestinal Metaplasia, Treatment
RFA for GIM Treatment
Use radiofrequency ablation (RFA) for Gastric intestinal metaplasia (GIM) treatment.
- Conditions
- Gastric Intestinal Metaplasia, Treatment, Radio-frequency Ablation
- Trial name
- NCT04348266
- Testing
- Radiofrequency ablation (RFA)
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastritis H Pylori, Gastritis Chronic
Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy
Esophagogastroduodenoscopy (EGD) is commonly performed in patients presenting with abdominal pain and dyspeptic symptoms, serving as a valuable diagnostic and therapeutic tool.
- Conditions
- Gastritis H Pylori, Gastritis Chronic, Intestinal Metaplasia
- Trial name
- NCT06269380
- Testing
- Esophagogastroduodenoscopy, Endoscopic biopsy sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 671 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Gastric Intestinal Metaplasia, Gastric Cancer
RCT: WLE vs. NBI in Upper Gastrointestinal Endoscopy
It is recognized that gastroscopy can miss intestinal metaplasia, dysplasia and early gastric cancer. This could conceivably be due to the fact that these lesions may only present as subtle mucosal changes on conventional white…
- Trial name
- NCT01945177
- Testing
- narrow band imaging, white light endoscopy
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Gastric Cancer, Atrophic Gastritis
AG & IM in CA Stomach Protocol
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
- Conditions
- Gastric Cancer, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT04184960
- Testing
- Gastroscopy and gastric biopsies
- Where
- 4 sites in Hong Kong, Japan and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gastritis, Atrophic, Helicobacter Pylori Infection
Diagnosis of Gastritis, H. Pylori Infection and Atrophic Gastritis in Dyspeptic Patients
Gastric cancer is the third most common cause of cancer-related death worldwide (1). Upper endoscopy is necessary to detect neoplastic macroscopic features at an early stage, but subtle abnormalities in the gastric mucosa are…
- Conditions
- Gastritis, Atrophic, Helicobacter Pylori Infection, Intestinal Metaplasia, Gastritis
- Trial name
- NCT04296513
- Testing
- High-Definition white light endoscopy., High-definition magnification with digital chromoendoscopy.
- Where
- Ecuador
- Volunteers
- 150 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Gastric Microbiota, Non-atrophic Gastritis
Difference of Gastric Microbiota in the Process of Correa's Model.
Helicobater pylori plays an important role in the development of gastric cancer. Eradication therapy can reducing the morbidity of gastric cancer, but can't totally prevent it especially when atrophy and more serious precancerous…
- Conditions
- Gastric Microbiota, Non-atrophic Gastritis, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT02833363
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shandong University
Cancer
Gene Therapy in Treating Patients With Cancer
RATIONALE: Inserting a gene that has been created in the laboratory into a person's white blood cells may make the body build an immune response to kill cancer cells.
- Trial name
- NCT00004178
- Testing
- therapeutic autologous lymphocytes
- Where
- United States
- Sponsor
- Roger Williams Medical Center
Intestinal Metaplasia
Confocal Laser Endomicroscopy for the Detection of Gastric Intestinal Metaplasia: a Randomized Controlled Trial
The purpose of this study is to assess whether confocal laser endomicroscopy can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT01024621
- Testing
- Endomicroscope, Standard endoscopy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shandong University
Gastric Cancer, Intestinal Metaplasia
Prediction of Gastric Cancer in Intestinal Metaplasia and Atrophic Gastritis
The primary objectives of this study are: To identify clinical or histological factors associated with gastric cancer development in patients with IM and AG To establish a machine learning algorithm for prediction of future…
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- GIMA (NCT04840056)
- Where
- Hong Kong
- Volunteers
- 1,300 people
- Sponsor
- Chinese University of Hong Kong
Stomach Cancer
Prognosis and Risk Factors of Gastric Cancer in Patients With Intestinal Metaplasia
This prospective cohort study aims to assess the incidence of gastric cancer in patients with intestinal metaplasia in body of stomach or angular incisure.
- Trial name
- GASTRIMED (NCT02325323)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrophic Gastritis
Usefulness of Serum Pepsinogen and Gastrin as the Predictive Biomarker of Atrophic Gastritis, Intestinal Metaplasia and Gastric Cancer in Korea
It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin, pepsinogen (PG) I, and PGII.
- Trial name
- NCT02184910
- Testing
- pepsinogen and gastrin
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Yonsei University