Clinical trials: Intestinal Health
Adhd, ALS
National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function.
The objective of the study will be to understand whether a supplementation of the diet with an active symbiotic, i.e. characterized by a mix of probiotics and a specially selected fiber with prebiotic activity combined with a…
- Conditions
- Adhd, ALS, Bronchial Asthma
- Trial name
- sPATIALS3 (NCT06005506)
- Testing
- Prebiotic fiber, Dietary fiber, Probiotic
- Where
- 4 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Institute of Biomedical Technologies-National Research Council, Italy
Colorectal Neoplasms
Efficacy of Web-based Self-management Support Intervention on Health Outcomes in Patients With Colorectal Cancer
The study aims to test the efficacy of a web-based interactive self-management support intervention on the primary outcome, quality of life, secondary outcomes, symptom distress, emotional distress, physical activity, and the…
- Trial name
- NCT05045976
- Testing
- Web-based interactive self-management support program
- Where
- 2 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Inflammation, Vaccine
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
The purpose of this study is to determine if adding dietary fiber, such as inulin, to a diet that does not have enough fiber would raise the levels of potentially beneficial bacteria, such as Bifidobacterium, in the gut.
- Conditions
- Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
- Trial name
- NCT04543877
- Testing
- Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Colorectal Cancer, Colorectal Neoplasms
The Impact of Choice on Colorectal Cancer Screening
In May of 2021, the United States Preventive Service Task Force (USPSTF) updated their colorectal cancer (CRC) screening guidelines by recommending screening at an earlier age for average-risk adults starting at the age of 45…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Health Screening
- Trial name
- CRC45+ (NCT05275530)
- Testing
- Active FIT Choice, Active Colonoscopy Choice, Active Dual Choice
- Where
- 2 sites in United States
- Volunteers
- 20,509 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Celiac Disease, Celiac Disease in Children
Celiac Disease in Childhood-Adulthood Transition
Aims of this study are to evaluate adolescents with celiac disease during their transition from pediatrics to adult care, and to develop better healthcare follow-up practices.
- Conditions
- Celiac Disease, Celiac Disease in Children, Transition of Care, Follow-up
- Trial name
- CeliCAT (NCT05084937)
- Testing
- CeliCAT form
- Where
- 5 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Tampere University Hospital
Obesity, Insulin Resistance
Fiber and Insulin Sensitivity
Based on previous research of the investigators group, the investigators hypothesize that slowly fermentable fibers with a high degree of polymerization that increase SCFA specifically in the distal colon are expected to have…
- Trial name
- NCT04714944
- Testing
- Whole fiber product
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Celiac Disease in Children, Gluten Enteropathy
Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease
Celiac disease (CD) is an autoimmune gastrointestinal disease that is caused by intolerance to gluten in the diet. The mainstay of treatment is a gluten-free diet (GFD).
- Conditions
- Celiac Disease in Children, Gluten Enteropathy, Diet; Deficiency, Adherence, Treatment
- Trial name
- NCT06038344
- Testing
- Gluten-free food guide teaching
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Cancer
Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy
The purpose of this study is to see if lactulose can improve the effectiveness of immunotherapy in patients with advanced cancer.
- Trial name
- (BLOOM) (NCT07354100)
- Testing
- Lactulose
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Chicago
Cancer, Pregnancy Related
Distribution of Biospecimens From Biorepositories/Biobanks for Research Use
This protocol seeks to assist biorepositories/biobanks in distributing their stored specimens and data to researchers that will actually utilize them to advance medicine and technology.
- Conditions
- Cancer, Pregnancy Related, Gastro-Intestinal Disorder, Cardio-Respiratory Distress
- Trial name
- NCT03884400
- Testing
- Specimens obtained from surgical, phlebotomy or other non-invasive procedure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- iSpecimen Inc
Dyspepsia
The Role of Narrow-Band Imaging Endoscopy in Diagnosing Gastric Intestinal Metaplasia
The purpose of this study is to determine if endoscope with NBI(narrow banding imaging)can detect intestinal metaplasia( consider pre malignant condition) and use a targeting biopsy in case of suspected intestinal metaplasia
- Trial name
- NCT00673699
- Testing
- Gastric mucosal biopsy
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Hillel Yaffe Medical Center
Colorectal Cancer, Breast Cancer
Momentum Project Heidelberg - Dealing Actively With a Cancerous Disease
The study, investigates the current physical activity promotion practices among physicians and nurses, as well as social norms toward physical activity during treatment among cancer patients and among physicians and nurses who…
- Conditions
- Colorectal Cancer, Breast Cancer, Prostate Cancer, Physicians
- Trial name
- NCT02678832
- Volunteers
- 2,200 people
- Sponsor
- Heidelberg University
Colorectal Cancer
Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting
This is a 3-arm randomized trial aimed at increasing rates of participation in colorectal cancer (CRC) screening by outreach to patients' homes using choice architecture informed by behavioral science principles.
- Trial name
- NCT04711473
- Testing
- Colonoscopy Only, Choice, FIT Only
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Malnutrition, Stunting
Child Health, Nutrition and Microbiome Development
Childhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children.
- Conditions
- Malnutrition, Stunting, Wasting, Underweight
- Trial name
- CHAMP (NCT05793294)
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Diarrhea Infectious, Algorithms
The Utility and Feasibility of Accessible Diarrhea Etiology Prediction Tool (ADEPT) in an Informal Healthcare Setting
Diarrheal disease remains a leading cause of morbidity and mortality for children under 5 globally. Accepted best practice for managing diarrhea in the absence of blood or suspicion of cholera is rehydration, however in resource…
- Conditions
- Diarrhea Infectious, Algorithms, Decision Support Systems, Clinical, Clinical Decision-making
- Trial name
- NCT07538531
- Testing
- Diagnostic test: Accessible Diarrhea Etiology Prediction Tool (ADEPT)
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Daniel Leung
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Arthritis, Asthma
Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems
Behavioral problems are part of many of the chronic diseases that cause the majority of illness, disability and death. Tobacco, diet, physical inactivity, alcohol, drug abuse, failure to take treatment, sleep problems, anxiety…
- Conditions
- Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes
- Trial name
- IBHPC (NCT02868983)
- Testing
- Integration
- Where
- United States
- Volunteers
- 4,025 people
- Sponsor
- University of Vermont
Genital Neoplasms, Female
Characterization of the Intestinal and Vaginal Microbiota in Long-term Survivors of Gynecological Cancer
The study proposes the characterization of the intestinal and vaginal microbiota in long-term radiated cervical and endometrial cancer survivors to study the association with long-term radiotherapy side effects.
- Trial name
- NCT05360459
- Testing
- Exposure to radiotherapy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maria Bailen Andrino