Clinical trials: Intervertebral Disc Degeneration
Degenerative Disc Disease
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into…
- Trial name
- HyaluronicAcid (NCT06325566)
- Testing
- Rexlemestrocel-L + HA mixture, Saline
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mesoblast, Ltd.
Degenerative Disc Disease
Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease
The objective of this study is to assess the safety and tolerability of YH14618 during 24 weeks of follow-up period after single administration in patients with degenerative disc disease.
- Trial name
- NCT01526330
- Testing
- YH14618
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yuhan Corporation
Degenerative Disc Disease, Spinal Stenosis
OssDsign® Spine Registry Study ("Propel")
The purpose of this multi-center, prospective, observational registry is to gather information on the clinical outcomes and real-world use of commercially available bone graft substitutes manufactured by OssDsign® AB, in patients…
- Trial name
- NCT05329129
- Testing
- OssDsign® Catalyst
- Where
- 16 sites in United States
- Volunteers
- 450 people
- Sponsor
- OssDsign
Spinal Disease, Degenerative Disc Disease
OssiMend BA in Posterolateral Instrumented Lumbar Fusion
The primary objective of this study is to measure the success rate of lumbar fusion in subjects at 12 months when instrumented lumbar arthrodesis is performed using OssiMend Bioactive Moldable as the bone grafting material
- Trial name
- NCT04775537
- Testing
- OssiMend™ Bioactive Moldable
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Collagen Matrix
Radiculopathy, Cervical, Myelopathy Cervical
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease
The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function.
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Neurological Abnormality, Disc Disease
- Trial name
- NCT05971329
- Testing
- Cervical Fusion (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zetagen Therapeutics, Inc
Degenerative Disc Disease
A Retrospective Study Using CALIBER® TLIF Expandable Spacer in the Treatment of DDD: 2 Year Follow-up.
The purpose of the study is to gather clinical and radiographic outcome data from patients who have undergone treatment with an expandable interbody spacer.
- Trial name
- NCT02388022
- Testing
- Degenerative Disc Disease
- Volunteers
- 200 people
- Sponsor
- Globus Medical Inc
Intervertebral Disk Degeneration
An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation
The aim of this trial is to evaluate if P-15 bone putty (investigational device) is not inferior in effectiveness and safety to local autologous bone (control device) when applied in instrumented anterior cervical discectomy and…
- Trial name
- NCT00310440
- Testing
- P-15 Synthetic osteoconductive bone substitute, Autologous bone
- Where
- 12 sites in United States, Canada
- Volunteers
- 319 people
- Sponsor
- CeraPedics, Inc
Degenerative Disc Disease
INDEPENDENCE Spacer for Lumbar Fusion
The primary objective of this study is to evaluate radiographic outcomes, intra-operative parameters, clinical outcomes, and patient satisfaction following circumferential fusion using the INDEPENDENCE® integrated plate and…
- Trial name
- NCT02299323
- Testing
- INDEPENDENCE
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Globus Medical Inc
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® device as compared to the LT-CAGE® device with autogenous bone in patients with symptomatic degenerative disc disease using an open…
- Trial name
- NCT01491386
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autogenous Bone/LT-CAGE® Device
- Volunteers
- 279 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease, Cervical Spinal Instability
Cervical Interbody Implant Study
The primary objective of this study is to evaluate the safety and performance of cervical spine surgery using interbody implants as measured by reported complications, radiographic outcomes, and patient-reported outcomes (PROs).
- Trial name
- NCT04689854
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Degenerative Disc Disease
Cervical Interbody Fusion Device Patient Registry
The registry has been designed as a prospective, observational program for patients undergoing anterior cervical discectomy and fusion (ACDF) procedures treated with TIDAL cervical interbody fusion device.
- Trial name
- NCT05114356
- Testing
- TIDAL Cervical Interbody Fusion implant
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Restor3D
Degenerative Disc Disease
Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion (PLIF) With Interbody Fusion
The primary objective of this clinical trial is to evaluate the success rates of Actifuse ABX and INFUSE in achieving bone fusion. The secondary objective of this clinical trial is to assess clinical outcome measurements.
- Trial name
- APPRAISET1 (NCT01013389)
- Testing
- Actifuse ABX, INFUSE, plus master granules (MGG)
- Where
- 2 sites in Australia, Netherlands
- Volunteers
- 20 people
- Sponsor
- Baxter Healthcare Corporation
Degenerative Disc Disease
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied…
- Trial name
- NCT03438747
- Testing
- P-15L Bone Graft, Local autologous bone in a TLIF with Instrumentation
- Where
- 34 sites in United States
- Volunteers
- 290 people
- Sponsor
- CeraPedics, Inc
Cervical Disc Degeneration
Study to Evaluate the Clinical and Radiographic Outcomes of the BEE® HA Cage for Anterior Cervical Discectomy and Fusion
Observational data collection of information after undergoing standard Cervical spine fusion surgery.
- Trial name
- NCT05631392
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Invibio Ltd
Low Back Pain
Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain
The primary objective of this study is to document and compare diagnostic test results and procedure safety in subjects undergoing both Functional Anaesthetic DiscographyTM (F.A.D.) and provocative discography (PD) and determine…
- Trial name
- SODA (NCT00443781)
- Testing
- functional anesthetic discography, provocative discography
- Where
- 10 sites in United States
- Volunteers
- 62 people
- Sponsor
- Medtronic Spine LLC
Subjects Treated With NMP as Part of Their Spine Surgery, Degenerative Disc Disease (DDD)
INDUCE: A Prospective 2-Year Spine Registry
The primary objective of this prospective, observational registry study is to evaluate the safety and effectiveness of Natural Matrix Protein® (NMP®) when used to promote fusion in the cervical or lumbar spine.
- Trial name
- NCT06971835
- Testing
- NMP
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Red Rock Regeneration Inc.
Degenerative Disc Disease, Degenerative Spondylolisthesis
Modulus in XLIF Study
The primary objective of this study is to evaluate the safety and performance of the Modulus 3D-printed titanium interbody implant in patients undergoing thoracic and/or lumbar XLIF as measured by reported complications…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis
- Trial name
- NCT04418817
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- NuVasive
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
The purpose of this clinical trial is to evaluate the implant (rhBMP-2/ACS/allograft bone dowel) as a method of facilitating spinal fusion in patients with degenerative disc disease.
- Trial name
- NCT01494493
- Testing
- rhBMP-2/ACS/allograft bone dowel, Autogenous bone/allograft bone dowel
- Volunteers
- 85 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease
Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion
This is a retrospective clinical study (chart review) of patients who have previously undergone Transforaminal Lumbar Interbody Fusion or Posterior Lumbar Interbody Fusion surgery with the FlareHawk expandable interbody fusion…
- Trial name
- NCT04057235
- Testing
- FlareHawk Interbody Fusion System
- Where
- 3 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Integrity Implants Inc.
Degenerative Disc Disease
AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain
This clinical trial evaluate the safety, tolerability and exploratory efficacy of targeted single injection of AMG0103 in subject with chronic discogenic lumbar back pain
- Trial name
- NCT03263611
- Testing
- AMG0103
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- AnGes, Inc.