Clinical trials: Intervention Study
Prediabetic State, Life Style
PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes
Nearly half of adults in the United States have or are at risk of developing type 2 diabetes. The overall goal of this community-engaged research is to examine the efficacy of an innovative couple-based lifestyle intervention to…
- Conditions
- Prediabetic State, Life Style, Intervention Study, Social Support
- Trial name
- PT2T (NCT06690788)
- Testing
- Individual intervention condition (PreventT2), Couple-based intervention condition (PreventT2 Together; couple-based adaptation of 2021 PreventT2; approved by the CDC in November 2022 as an Alternate Curriculum for use in the NDPP)
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Utah
PCOS- Polycystic Ovary Syndrome, Nutrition Intervention
Nutrition Intervention for Women With Polycystic Ovary Syndrome
The goal of this clinical trial is to evaluate whether different dietary models can improve clinical, metabolic, hormonal, anthropometric, and quality-of-life parameters in women with polycystic ovary syndrome (PCOS).
- Conditions
- PCOS- Polycystic Ovary Syndrome, Nutrition Intervention, Nutrition Assessment
- Trial name
- NCT07298603
- Testing
- FertilOMed Diet, MedDiet
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Patient-Reported Outcome Measures (PROMs), Pragmatic Trial
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
The goal of this pragmatic clinical trial is to learn if the WE BEAT program, a 5-week group-based online wellbeing and skill-building program, can help teens with congenital heart disease (CHD) improve their ability to handle…
- Conditions
- Patient-Reported Outcome Measures (PROMs), Pragmatic Trial, Adolescent Congenital Heart Disease, Resiliency-building Intervention
- Trial name
- PHN WBC (NCT07525843)
- Testing
- Telemedicine-based resiliency-building intervention
- Where
- 14 sites in United States
- Volunteers
- 390 people
- Sponsor
- Carelon Research
Dental Anxiety, Music Intervention
Effect of Music on Dental Anxiety and Physiological Responses During Dental Drill and Suction Sounds
Dental anxiety is common and may be triggered or increased by sounds associated with dental treatment, particularly the sound of a dental drill and suction device.
- Trial name
- MUS-DENT (NCT07827118)
- Testing
- Music intervention
- Where
- Pakistan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Lifestyle Intervention, Lifestyle Risk Reduction
Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial
Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial (LIGHT) is a multi-center, randomized, controlled, lifestyle intervention trial among 300 older adults (≥50 years) with subjective cognitive…
- Conditions
- Lifestyle Intervention, Lifestyle Risk Reduction, Cognitive Decline, Dementia
- Trial name
- LIGHT (NCT06832761)
- Testing
- Personalized lifestyle intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Autism, Intervention (Training) Condition
Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder
This study evaluates the efficacy of the Companion Mind-Drawing Cooperative Game Program, a parent-mediated, home-based structured play intervention targeting social cognitive development in young children with autism spectrum…
- Conditions
- Autism, Intervention (Training) Condition, Social Cognition, Cognition Improvement
- Trial name
- PMSC-ASD (NCT07708246)
- Testing
- Companion Mind-Drawing Cooperative Game Program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
IVUS-Guided Sirolimus-Coated Balloon Versus Sirolimus-Eluting Stent for De Novo Large Vessel Lesions in ACS
The goal of this interventional study is to evaluate the efficacy and safety of an intravascular ultrasound (IVUS)-guided sirolimus-coated balloon (SCB)-based strategy versus planned sirolimus-eluting stent (SES) implantation in…
- Trial name
- IVUS-SCB (NCT07796412)
- Testing
- IVUS-Guided Sirolimus-Coated Balloon, IVUS-Guided Sirolimus-Eluting Stent
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Postoperative Pain Management, Anxiety
The Effect of Preoperative Hugging With Family Members on Preoperative Anxiety Levels and Postoperative Pain
The aim of this randomized prospective study is to examine the effect of preoperative family hugging (for at least 20 seconds) on preoperative anxiety levels and postoperative pain.
- Conditions
- Postoperative Pain Management, Anxiety, Non-Pharmacological Interventions
- Trial name
- NCT07369544
- Testing
- Patients will be given the opportunity to hug family members for at least 20 seconds before the surgery., The standard anesthesia protocol will be followed
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Intervention Condition, Control (Delayed Training) Condition
Online Socio-emotional Dyad Training for Healthcare Students' Well-being and Social Skills
In this Edu:Social Health Care project, a randomized controlled trial with a socio-emotional intervention and a waitlist control group will be conducted to evaluate the effects of a partner-based empathy-compassion Dyad mental…
- Trial name
- EduSocHealth (NCT07407413)
- Testing
- Experimental: Empathy- and compassion-based socio-emotional mental training (EmCo), Waitlist Control Group (WCG)
- Where
- Germany
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Max Planck Social Neuroscience Lab
Language Delay, Substance Use Disorders
Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services
The goal of this clinical trial is to test ways to improve early language development among young children of parents with substance use disorder (SUD).
- Conditions
- Language Delay, Substance Use Disorders, Language Disorders in Children, Language Development
- Trial name
- NCT07529327
- Testing
- Comilia Group, Interaction Review Enhancement, Practical Support Enhancement
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- University of Oregon
Physical Activity, Fitness Tracker
Guided Physical Activity Counseling: A Pilot Study
This 1-arm pilot study will test the feasibility of recruitment and use of the Physical Activity Counseling Tool (PACT) in 40 UC San Diego Health patients.
- Conditions
- Physical Activity, Fitness Tracker, Behavioral Intervention, Primary Care
- Trial name
- NCT07869784
- Testing
- Physical Activity Counseling Tool (PACT)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Diego
Neurofibromatosis 1 (NF1), Executive Function (Cognition)
Cognitive Intervention for Children and Adolescents With NF1
Psychological interventions have been shown to be effective for managing cognitive and mental health challenges in different patient populations.
- Conditions
- Neurofibromatosis 1 (NF1), Executive Function (Cognition), Cognitive Intervention
- Trial name
- NCT07869914
- Testing
- Unstuck and On Target!
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Oxygen Saturation, Percutaneous Coronary Intervention
Effects of Pilates Breathing Versus Diaphragmatic Breathing on Oxygen Saturation and Heart-Rate Variability in Post-Percutaneous Coronary Intervention Patients
Percutaneous Coronary Intervention (PCI) is a common procedure used to restore coronary blood flow in patients with coronary artery disease.
- Trial name
- NCT07872098
- Testing
- Pilates Breathing, Diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Advanced Cancer, Demoralization
A Feasibility Study of a Digitally-enabled Psychological Intervention for Demoralization in Advanced Cancer Patients
Advanced cancer is a leading cause of death worldwide and in China. Cancer patients often face reduced independence and self-care abilities, which may lead to psychological disturbances such as helplessness, hopelessness, or…
- Conditions
- Advanced Cancer, Demoralization, Psychological Intervention
- Trial name
- NCT07872254
- Testing
- A digitally-enabled positive psychological intervention for demoralization in advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Elective Percutaneous Coronary Intervention, Ischemic Reperfusion Injury
Cardio-protective Effect of Metformin in Patients Undergoing PCI
This is a two-arm randomized parallel study. Patients who will be meeting the above-mentioned criteria and agree to take part in the study, were asked to sign an informed consent prior conducting the study.
- Trial name
- NCT05708053
- Testing
- Metformin
- Where
- 3 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pregnancies at Increased Risk for Excessive Gestational Weight Gain, Ecological Momentary Assessment and Intervention
Continuous Glucose and E-Monitoring to Support Healthy Weight Gain in Pregnancies - The GEM Study
This single-arm pilot study will evaluate the feasibility and acceptability of a remotely delivered behavioral lifestyle intervention, adapted from the SmartMoms framework, to promote health gestational weight gain in pregnant…
- Conditions
- Pregnancies at Increased Risk for Excessive Gestational Weight Gain, Ecological Momentary Assessment and Intervention, Continuous Glucose Monitor
- Trial name
- GEM (NCT06666257)
- Testing
- Continuous Glucose and E-Monitoring to Support Healthy Weight Gain in Pregnancy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Arkansas Children's Hospital Research Institute
High-Risk Percutaneous Coronary Intervention (High-risk PCI)
ELEVATE High-Risk PCI Pivotal Study
The ELEVATE III Pivotal Study is a prospective, multi-center, open-label, interventional, randomized, controlled study with an active control group.
- Trial name
- ELEVATE III (NCT07001332)
- Testing
- Elevate, Impella
- Where
- 33 sites in United States
- Volunteers
- 290 people
- Sponsor
- Magenta Medical Ltd.
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
Multi Vessel Coronary Artery Disease, Percutaneous Coronary Intervention
Clinical Impact of DCB-based Versus DES-based Intervention in Patients With MVCAD
This study aimes to compare the clinical outcomes of drug-coated balloon-based percutaneous coronary intervention (DCB-based PCI) and drug-eluting stent-based percutaneous coronary intervention (DES-based PCI) in patients with…
- Trial name
- DCBMultivessel (NCT07539324)
- Testing
- GENOSS® DCB (Paclitaxel-coated PTCA balloon catheter), Contemporary Drug-Eluting Stents (DES)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Genoss Co., Ltd.
Probiotic Intervention, Healthy Adult Participants
Early Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label pilot feasibility study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Trial name
- ePROFILE20 (NCT07841457)
- Testing
- Probiotic Supplement (1C-01)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- OneCarbon