Clinical trials: Intervention
Perinatal Depression
Responsive e-Health Intervention for Perinatal Depression in Healthcare Settings
Perinatal depression is experienced by at least 14-20% of pregnant and postpartum women, and is recognized as the most common complication of childbirth.
- Trial name
- MMB (NCT03995316)
- Testing
- Treatment As Usual + MMB 2.0, Treatment As Usual Only
- Where
- 2 sites in United States
- Volunteers
- 191 people
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Chronic Kidney Disease
Chronic Kidney Disease Among Frail Elderly
Chronic kidney disease is a common diagnosis in the elderly population and it is associated with significant morbidity and health care costs. The prevalence rates increase with age to about 40% for adults aged > 65 years.
- Trial name
- FRED-CKD (NCT02351349)
- Testing
- multidisciplinary intervention
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sameena Iqbal
Stroke, Shoulder Injury
STRIPS: Shoulder Taping Reduces Injury and Pain in Stroke
Background and Rationale: The most commonly seen disabilities in stroke patients are shoulder injuries such as shoulder pain, glenohumeral subluxation, spasticity of shoulder muscles, soft-tissue trauma, rotator cuff tears, and…
- Trial name
- STRIPS (NCT01062308)
- Where
- 2 sites in India
- Volunteers
- 162 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Polycystic Ovary Syndrome, Metabolic Syndrome
Metabolic Syndrome in PCOS: Precursors and Interventions
The purpose of this study is to investigate the metabolic effects of anti-androgens and oral contraceptive pills (OCPs), compared with placebo, in the treatment of women with PCOS.
- Trial name
- NCT00442689
- Testing
- flutamide, ethinyl estradiol 35 mcg and drospirenone 3 mg
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Northwestern University
Atrial Fibrillation, Deep Vein Thrombosis
Randomized Trial of Interventions to Improve Warfarin Adherence
The purpose of this research study is to see if a lottery which provides the opportunity to win money, a reminder system using a "Med-eMonitor", or the combination of both might be useful in helping patients to achieve better…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Dilated Cardiomyopathies
- Trial name
- WIN3 (NCT00904982)
- Testing
- Financial Incentive and Med-eMonitor, 2Med-eMonitor
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- University of Pennsylvania
Rheumatoid Arthritis, Ankylosing Spondylitis
A Study of Rheumatoid Arthritis Treatment With Enbrel in Adult Patient in Outpatient Department
This is an open-label, multicenter and observational study in China, which is designed to record the data of RA \& AS patients within 52 weeks after rheumatologists decided to prescribe etanercept, and evaluate the safety and…
- Trial name
- ENBREL NIS CN (NCT01411215)
- Testing
- Enbrel
- Where
- 15 sites in China
- Volunteers
- 160 people
- Sponsor
- Pfizer
Intubation, Cardiovascular Surgical Procedure
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac surgery decreases the…
- Trial name
- NCT04782817
- Testing
- Recommendation for high flow nasal cannula oxygen therapy order set, Provider choice usual care order set
- Where
- United States
- Volunteers
- 3,568 people
- Sponsor
- Vanderbilt University Medical Center
Patient Adherence
Evaluation of a mHealth Intervention to Increase Adherence to Triage of Self-collected HPV+ Women (ATICA Project)
Background: Cervical cancer is one of the leading causes of cancer death among women worldwide, with more than 85% of cases occurring in low- and middle-income countries.
- Trial name
- ATICA (NCT03478397)
- Testing
- Multicomponent mHealth Intervention
- Where
- Argentina
- Volunteers
- 5,389 people
- Sponsor
- Centro de Estudio de Estado y Sociedad
Dry Eye Disease With Severe Keratitis
3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)
The proposed 36-month Post Approval Efficacy Study (PAES) is a prospective, interventional, multicentre study to explore the long-term evolution of signs and symptoms, and occurrence of complications in Dry Eye Disease (DED)…
- Trial name
- NCT04144413
- Testing
- Open-label Ikervis, Masked Ikervis, Vehicle Comparator: Masked Vehicle
- Where
- 45 sites in Czechia, France and 5 more
- Volunteers
- 350 people
- Sponsor
- Santen SAS
Cardiovascular Disease, Preeclampsia
Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia
This study will compare two arms in a randomized clinical trial of cardiovascular risk prevention in women with a history of preeclampsia.
- Conditions
- Cardiovascular Disease, Preeclampsia, Hypertension, Post-partum Weight Retention
- Trial name
- HH4M (NCT02147626)
- Testing
- Web-based educational and motivational modules, Information and Screening Group
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Physical Inactivity
Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease
This is a four-week pilot randomized controlled trial of a behavioral intervention in older adults at risk for Alzheimer's disease. Older participants are a subgroup from the PREVENT-AD longitudinal cohort.
- Trial name
- HABS (NCT06038643)
- Testing
- Motivational behavioural intervention and daily activities monitoring, Active Control
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Fetal Alcohol Spectrum Disorders
Trial of the Families Moving Forward (FMF) Connect Mobile Health Intervention
The purpose of this study is to test a new smartphone "app" for parents/caregivers of children with fetal alcohol spectrum disorder (FASD). The app is called Families Moving Forward (FMF) Connect.
- Trial name
- NCT04194489
- Testing
- FMF Connect
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Alcohol Drinking, Adolescent, Drinking Behavior
Brief Intervention to Prevent Alcohol Socialization (BIPAS Alcohol)
Early alcohol socialization occurs within the family. This multi-level, high-reach, low-intensity intervention to prevent early alcohol use capitalizes on the influence of providers, immunization timing, and pediatric guidelines…
- Conditions
- Alcohol Drinking, Adolescent, Drinking Behavior, Drinking, Alcohol, Adolescent Behavior
- Trial name
- NCT05520333
- Testing
- BIPAS Alcohol
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
This study aimed to determine the efficacy, safety and tolerability of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in pediatric patients (6 months to < 18 years of…
- Trial name
- KALUMI (NCT04546633)
- Testing
- KAF156, LUM-SDF, Coartem
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
HIV, Risky Sex Prevention
A Risky Sex Prevention Intervention for Middle School Age Minority Girls
African American adolescent females are more likely to have sex at an early age, to have older sex partners that have had multiple sexual experiences, and are less likely to use a condom than their white counterparts.
- Trial name
- GEMM (NCT02103218)
- Testing
- Education, activities, empowerment, racial pride building, General Health education, activities
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- University of North Carolina, Greensboro
Virtual Reality, Pediatrics
Virtual Reality During Procedures in Pediatric Patients
This stratified, randomized, controlled trial compared coping and distress between child life supported virtual reality engagement and child life support during painful procedures in the pediatric emergency department.
- Trial name
- NCT03686176
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder (AUD), Substance Use Disorders
The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use
This study aims to validate W-SUDs as a digitally-delivered substance use disorder program through a fully-powered randomized control trial that will test the comparative efficacy of the mobile-app based substance use disorder…
- Trial name
- NCT04925570
- Testing
- W-SUDs, Digitally-delivered Psychoeducation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Woebot Health
Post-traumatic Stress Disorder, Generalized Anxiety Disorder
Primary Care Intervention Strategy for Anxiety Disorders
This study will compare the effectiveness of an intervention strategy for the treatment of people with post traumatic stress disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder in the primary care…
- Conditions
- Post-traumatic Stress Disorder, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- NCT00347269
- Testing
- Cognitive-behavioral therapy, Psychotropic medication optimization, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
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