Clinical trials: Intervention, open to volunteers
Endodontics, Regenerative Endodontic Procedures
The Effect of Using Different Scaffolds in Retreated Teeth on The Clinical and Radiological Success of Regenerative Endodontic Treatment
This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
- Conditions
- Endodontics, Regenerative Endodontic Procedures, PRF, i-PRF
- Trial name
- NCT07721051
- Volunteers
- 60 people
- Sponsor
- Kırıkkale University
Supraclavicular Plexus Block Procedure (SCPB), ESRD
Ultrasound Guidance Intercostobrachial Nerve Block in AVF Superficialization
The present clinical study will be undertaken to evaluate and compare the clinical efficacy of two different volumes of distal ICBN block when combined with a baseline supraclavicular brachial plexus block during…
- Trial name
- NCT07852351
- Testing
- Distal Intercostobrachial Nerve Block, Supraclavicular Plexus Block Procedure (SCPB)
- Volunteers
- 76 people
- Sponsor
- Assiut University
Smoking, Smoking Cessation
Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care
This study will modify an existing evidence-based parental tobacco cessation intervention (the Clinical Effort Against Secondhand Smoke Exposure, or CEASE) delivered in pediatric primary care clinics to address shared tobacco use…
- Trial name
- NCT06839729
- Testing
- CEASE+
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Music Therapy, Anxiety
Therapy on Perioperative Anxiety and Pain in Patients
This study aims to explore the effects of preoperative education combined with intraoperative music therapy on perioperative anxiety and pain in patients undergoing elective cesarean section.
- Conditions
- Music Therapy, Anxiety, Health Education
- Trial name
- NCT06970431
- Testing
- eoperative Education + Intraoperative Music Therapy Arm, Preoperative Education Alone Arm
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Sleep Disturbance, Autism Spectrum Disorder
Community-Engaged Sleep Intervention for School-Aged Children With Autism Spectrum Disorder
As many as 78% of children with autism spectrum disorder (ASD) have significant sleep disturbance compared to 20% of children without ASD.
- Trial name
- NCT07007819
- Testing
- Modified Sleep and Circadian Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Western Reserve University
Healthy Adults
Effect of Probiotic Intervention on Travel-Related Health Conditions During Short-Term Overseas Travel
International travel disrupts gut health through dietary changes, microbial exposure, and stress, often causing gastrointestinal symptoms like traveler's diarrhea and sleep disturbances.
- Trial name
- NCT07163819
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Pain (Knee), Pain and Anxiety
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
The goal of this clinical trial is to compare the effects of heart rate variability biofeedback (HRVB), mindfulness meditation, and psychological education in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain (Knee), Pain and Anxiety, TKA
- Trial name
- NCT07896954
- Testing
- Heart rate variability biofeedback, Mindfulness, psychoeducation
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Age 3 to 7 Years, Mild Autism Spectrum
the Effect of Formulation on Anxiety in Autist Childre A Randomized Controlled Trial Assesses Spirulina Syrup Plus Risperidone in Children With Non-idiopathic Autism. Anxiety is Measured Using the SCAS (Parent Version) Via Daily Online Surveys for One Week and Throughout a 3-month Follow-up Period.
The aim of this study is to evaluate the effect of a Spirulina syrup formulation on reducing anxiety in children with non-idiopathic autism.
- Conditions
- Age 3 to 7 Years, Mild Autism Spectrum, no Other Illness or Disorder
- Trial name
- Autism Anxiety (NCT07060872)
- Testing
- Spirulina Syrup, Risperidone
- Where
- Iran
- Volunteers
- 82 people
- Sponsor
- Shahid Sadoughi University of Medical Sciences and Health Services
Post Surgical Respiratory Failure, Respiratory Complication
Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS)
Investigators will enroll 493 patients who will undergo non-cardiac surgery, receive supplemental oxygen via face mask or nasal cannula, and will be on continuous pulse oximetry monitor in the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Surgical Respiratory Failure, Respiratory Complication, Opioid Induced Respiratory Depression, Respiratory Arrest
- Trial name
- NCT07793981
- Testing
- Linshom Continuous Predictive Respiratory Monitoring
- Where
- 2 sites in United States
- Volunteers
- 394 people
- Sponsor
- Linshom Medical, Inc.
Influenza, Immunosenescence
Effect of Oral Supplement on Influenza Vaccine Long-term Response
This is a follow-up study of a previously completed randomized controlled trial (NCT06827873) that investigated the effects of oral supplements on influenza vaccine response in adults aged 60-70 years.
- Trial name
- EOSIIVE-F (NCT07357467)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Coronary Artery Disease
Colchicine in Belgium in Patients With Coronary Artery Disease After Percutaneous Coronary Intervention
The main aim of this trial is to determine whether there are fewer cardiovascular events when patients with coronary artery disease take a low dose of colchicine of 0.5 mg daily on top of optimal standard treatment after…
- Trial name
- COL BE PCI (NCT06095765)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- 19 sites in Belgium
- Volunteers
- 2,770 people
- Sponsor
- AZ Sint-Jan AV
Breast Cancer, Breast Neoplasms
Feasibility of a Preoperative, Multimodal Lifestyle Intervention in Patients With Breastcancer
The primary objective of this study is to investigate the feasibility of a multimodal prehabilitation programme consisting of MIET during neoadjuvant intravenous chemotherapy infusion, HITT and strength training during the last…
- Trial name
- APRIORI (NCT06266312)
- Testing
- A multimodal prehabilitation programme
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
Consent Process
Examining the Efficacy of a Digital Media Intervention to Increase Recruitment Rates
WHEAT-Boost is a Study Within A Trial (SWAT) that aims to improve how families are recruited into neonatal research studies by testing a new way of sharing information.
- Trial name
- WHEAT-Boost (NCT07284329)
- Testing
- Intervention (Video) Arm
- Where
- 15 sites in Canada
- Volunteers
- 787 people
- Sponsor
- IWK Health Centre
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
TURN-IT FOG: Improving Turning and Freezing of Gait in People With PD
The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable…
- Trial name
- NCT06815302
- Testing
- Experimental intervention, Active intervention
- Where
- 3 sites in United States, Brazil
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Ileostomy - Stoma, Caregiver
The Effect of Real Patient Interactive Stoma Care Management Teaching
Colorectal cancer is a type of cancer that is on the rise worldwide. Ileostomy with surgical treatment is one of the common treatment methods for this cancer.
- Conditions
- Ileostomy - Stoma, Caregiver, Care Management, Care Participation
- Trial name
- NCT06979102
- Testing
- Real Patient Interactive Stoma Care Management Teaching, Standard Stoma Care Management Teaching
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
PTSD, Obesity
Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial
Obesity and post-traumatic stress disorder (PTSD) are common among Veterans. PTSD increases risk for obesity, impacting functioning, health, quality of life, and premature mortality.
- Trial name
- HARPP (NCT07010757)
- Testing
- HARPP, control arm for HARPP trial
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- VA Office of Research and Development
Common Mental Health Problems, Anxiety
Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders
The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way.
- Conditions
- Common Mental Health Problems, Anxiety, Depression Disorders
- Trial name
- UpLift-X (NCT06722781)
- Testing
- Unified Protocol
- Where
- 2 sites in United Kingdom
- Volunteers
- 660 people
- Sponsor
- Rotherham Doncaster and South Humber NHS Foundation Trust
Weight Loss, Weight Regain
Testing a Tailored Approach to Long-Term Weight Loss Success
The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight.
- Conditions
- Weight Loss, Weight Regain, Obesity & Overweight
- Trial name
- NCT07577765
- Testing
- Adaptive weight regain prevention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pulp Necrosis
This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit
This randomized clinical trial aims to compare the step-back and step-down root canal preparation techniques in patients with pulp necrosis. The study will evaluate which technique results in less postoperative pain.
- Trial name
- NCT07290192
- Testing
- Step down technique
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi
Kidney Failure, Chronic Therapy; Hemodialysis
Web-based Advance Care Planning Intervention for Patients With Kidney Failure on Dialysis: Pilot Testing of 'My Voice'
'My Voice' is a website intervention developed to enable advance care planning (ACP) conversations for patients with kidney disease on dialysis, educate patients on their illness, help identify their goals and preferences for EOL…
- Trial name
- NCT07309367
- Testing
- My Voice website intervention with patient and caregiver modules
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
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