Clinical trials: Internal Medicine, open to volunteers
Insomnia, Obesity
Qing-Xin-Jiao-Tai Decoction for Insomnia Comorbid With Obesity Presenting With Heart-Kidney Non-interaction Syndrome
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of Qing-Xin-Jiao-Tai Decoction (QXJTD), a Traditional Chinese Medicine formula, in treating adults (aged 18-65) suffering from both…
- Trial name
- NCT07754383
- Testing
- Qingxin Jiaotai Decoction
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Fohow Pharmaceutical Group
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Insomnia Disorders
Evaluating the Efficacy and Safety of Daridorexant Transition From BZRAs in Insomnia Patients（EASY-TIP）
Brief Summary: This study is a prospective, multicenter, open-label cohort study designed to evaluate the efficacy and safety of transitioning adult patients with insomnia from benzodiazepine receptor agonists (BZRAs) to…
- Trial name
- EASY-TIP (NCT07733414)
- Testing
- Daridorexant
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypomagnesemia
Magnesium Deficiency In Patients Hospitalized in Internal Medicine Wards
Hypomagnesemia is a common entity in the inpatient and outpatient setting. in previous retrospective study hypomagnesemic patients have higher mortality and longer hospitalization.
- Trial name
- NCT03088852
- Testing
- Magnesium Citrate 100 MG
- Where
- Israel
- Volunteers
- 330 people
- Sponsor
- Frieda Wolf
Restless Legs Syndrome (RLS)
Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI
The pathophysiology of restless legs syndrome (RLS) is not well understood: it is thought to involve intracerebral iron deficiency and dopaminergic dysregulation.
- Trial name
- IRON-RLS (NCT07822607)
- Testing
- Ferric Carboxymaltose Injection [Ferinject], Randomization, Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Montpellier
Cardiac Amyloidosis
Description of a Retrospective Cohort of Patients With Transthyretin Cardiac Amyloidosis (ATTR-CA) in Internal Medicine
In 2024, the prevalence of TTR cardiac amyloidosis is difficult to determine precisely. Indeed, the disease has long been underdiagnosed due to a lack of effective treatment and non-invasive diagnostic methods.
- Trial name
- ATTR-CA (NCT06907836)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Arterial Hypertension (PAH), Sleep-disordered Breathing (SDB)
PAH-SDB: Sleep-Disordered Breathing and Outcomes in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease characterized by increased pulmonary vascular resistance, right ventricular dysfunction, and clinically important morbidity and mortality.
- Trial name
- PAH-SDB (NCT07852403)
- Testing
- Standardized Overnight Sleep and Cardiorespiratory Monitoring
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Internal Derangement
Intra-articular Injection of Medications in TMJ After Arthrocentsis
The aim of this study: to evaluate the injection of hyaluronic acid and corticosteroids mixture leads to better clinical outcomes in terms of improve maximum mouth opening and reduce pain compared with hyaluronic acid and prp…
- Trial name
- NCT07598253
- Testing
- Arthrocentesis with ringer solution
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
OSAS (Obstructive Sleep Apneas Syndrome), DISE
The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy
This study seeks to compare the clinical efficacy and safety of the novel sedative Remimazolam with Dexmedetomidine in Drug-Induced Sleep Endoscopy (DISE), evaluating their performance in sedation depth stability, incidence of…
- Conditions
- OSAS (Obstructive Sleep Apneas Syndrome), DISE, Sedation
- Trial name
- NCT07459322
- Testing
- Remimazolam, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University Hospital
Obesity, Overweight
AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea.
- Conditions
- Obesity, Overweight, Obstructive Sleep Apnoea
- Trial name
- AMAZE 3 (NCT07571005)
- Testing
- NNC0487-0111
- Where
- 80 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Sleep Apnea, Obstructive
Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep
This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is…
- Trial name
- Nasal vs Oral (NCT06789770)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Anxiety, Depression - Major Depressive Disorder
Transcendental Meditation Intervention to Reduce Burnout and Enhance Resilience Among NewYork-Presbyterian Hospital and Weill Cornell Medicine Employees and Residents
The goal of this study is to learn if a meditation intervention called Transcendental Meditation or TM can be used in a small department at Weill Cornell Medicine to help reduce employees' levels of burnout, anxiety, insomnia…
- Conditions
- Anxiety, Depression - Major Depressive Disorder, Burnout, Insomnia
- Trial name
- NCT07868783
- Testing
- Transcendental Meditation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sudden Sensorineural Hearing Loss (SSNHL), Tinnitus
'Inner Ear Support' Oral Capsule in Patients With Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is a medical condition where people experience rapid hearing loss, usually in one ear, over a short period of time (typically within 72 hours).
- Trial name
- NCT06997406
- Testing
- Inner ear support
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Far East Bio-Tec Co., Ltd
Hemorrhoids Second Degree, Traditional Chinese Medicine (TCM)
Traditional Medicine Syndromes in Internal Hemorrhoids: a Cross-Sectional Study
This study aims to investigate the characteristics of Traditional Medicine (TM) syndromes in patients diagnosed with internal hemorrhoids at Le Van Thinh Hospital.
- Trial name
- TMS-Hemorrhoid (NCT06876428)
- Volunteers
- 150 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Mild Cognitive Impairment, Cognitive Function
Binaural Beats for Cognitive Function in Older Adults With Mild Cognitive Impairment in Nursing Homes
This study will evaluate whether binaural beats can improve cognitive function in older adults with mild cognitive impairment living in nursing homes.
- Trial name
- BB-MCI (NCT07735910)
- Testing
- Binaural Beats Embedded in Old Songs, Old Songs
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- China Medical University, China
Insomnia, Nonorganic, Chronic Insomnia Disorder
Individualized TCM Pattern-Based Thread-Embedding Acupuncture Plus Auricular Acupressure for Chronic Insomnia
Chronic insomnia disorder is a common sleep disorder associated with impaired daytime functioning and may be accompanied by alterations in immune-inflammatory and gut-related biological processes.
- Trial name
- NCT07552714
- Testing
- Thread embedding acupuncture, Auricular acupressure
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Artificial Intelligence (AI), Clinical Reasoning
Teaching Doctors in Training to Reason With Artificial Intelligence
The purpose of the TEACH-AI study is to assess whether a brief, structured workshop on artificial intelligence can improve the performance of medicine doctors in training (i.e.
- Conditions
- Artificial Intelligence (AI), Clinical Reasoning, Clinical Decision-making, Medical Education
- Trial name
- TEACH-AI (NCT07813754)
- Testing
- Workshop-First
- Where
- 4 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Ovarian Neoplasms Malignant, Sleep Initiation and Maintenance Disorders
Tiaoshen Anti-cancer Protocol and CBT for Insomnia and Survival in Ovarian Cancer
Study Title: A Multicenter, Randomized Controlled Trial of Tiaoshen Anti-cancer Protocol Combined with Cognitive Behavioral Therapy for Insomnia in Improving Sleep and Survival in Ovarian Cancer Patients Purpose: This study aims…
- Conditions
- Ovarian Neoplasms Malignant, Sleep Initiation and Maintenance Disorders, Medicine, Chinese Traditional, Chinese Herbal Medicine
- Trial name
- NCT07550205
- Testing
- Tiaoshen Anti-cancer Granules, Cognitive Behavioral Therapy for Insomnia, Standard First-line Platinum-based Chemotherapy
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Patients With Metastatic Castration-resistant Prostate Cancer
Evaluation of the Concordance Between Pre-therapy Dosimetry Performed From 68Ga-PSMA-11 Dynamic PET and Post-treatment Dosimetry of 177Lu-PSMA-617 Vectorized Internal Radiotherapy in Patients With Metastatic Prostate Cancer Resistant to Hormonal Castration.
Patients undergo three diagnostic PET scans: 18F-FDG PET scan / 18F-Choline PET scan and 68Ga-PSMA PET scan. Following the diagnostic PET scans, and if patients' eligibility for 177Lu-PSMA-617 IVR treatment is confirmed, SPECT…
- Trial name
- GaLuPro (NCT06136377)
- Testing
- 177Lu-PSMA-617 PET scan
- Volunteers
- 35 people
- Sponsor
- Centre Georges Francois Leclerc