Clinical trials: Intermittent Theta Burst Stimulation
Major Depression, Healthy Participants
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Many people with depression do not get better with standard treatments like medications or talk therapy. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation treatment that uses magnetic pulses to stimulate…
- Trial name
- NCT07593222
- Testing
- TMS, D-cycloserine, Dextromethophan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alzheimer Disease
Novel Personalized Non Invasive Combined Magnetic and Electrical Stimulation of the DMN in Mild AD Patients
Alzheimer's disease (AD) is increasingly recognized as a disorder marked by early synaptic dysfunction and disrupted brain network connectivity, beyond the traditional focus on amyloid pathology.
- Trial name
- CMES_AD (NCT07075770)
- Testing
- Combined iTBS-tACS
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Chronic Stroke
Magnetic Brain Stimulation and Computer-based Motor Training for Rehabilitation After Stroke
The goal of the present clinical trial is to explore whether an innovative technology-based approach can help individuals who have had a stroke and can no longer move their hands with ease.
- Trial name
- NCT06116942
- Testing
- Active rTMS
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Cognition, Stress Reaction
rTMS to Enhance Cognitive Performance and Promote Resilience
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as…
- Trial name
- NCT04123496
- Testing
- rTMS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Depressive Disorder, Sleep Disturbance
iACT & iTBS for Sleep Quality in Depressed Adolescents
This study evaluated whether combining an internet-delivered Acceptance and Commitment Therapy program with intermittent theta burst stimulation improves subjective sleep quality in adolescents with depressive disorders and sleep…
- Trial name
- NCT07807072
- Testing
- Internet-Delivered Acceptance and Commitment Therapy, Intermittent Theta Burst Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Central China Normal University
Movement Disorders
Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in People With Functional Movement Disorders
Background: Functional movement disorder (FMD) causes involuntary movements, such as spasms, shaking, or jerks. These symptoms are not due to a recognized neurological or medical cause.
- Trial name
- NCT03263013
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia, Functional Magnetic Resonance Imaging
Effect of Intermittent Theta Burst Stimulation (iTBS) for Alleviating Symptoms of Schizophrenia Patients
To investigate the treatment effect of intermittent theta-burst transcranial magnetic stimulation on symptomatic relief of schizophrenia patients, and the underlying neural mechanism by functional MRI and the resting…
- Conditions
- Schizophrenia, Functional Magnetic Resonance Imaging, Transcranial Magnetic Stimulation
- Trial name
- NCT03868358
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- WANG KAI
Bipolar Disorder
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
The objective of this study protocol is to test whether intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) can strengthen functional connectivity with a key region in…
- Trial name
- NCT06274567
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Massachusetts General Hospital
Stroke, Ischemic
Effects of Intermittent Theta Burst Stimulation in Addition to Constraint-Induced Movement Therapy in Stroke Patients
In recent studies, it has been reported that intermittent theta-burst stimulation (iTBS) provides additional benefits when applied in adjunct to the rehabilitation in all stages of stroke (acute, subacute, or chronic).
- Trial name
- NCT05308667
- Testing
- Rehabilitation (modified constraint-induced movement therapy), non-invasive brain stimulation (intermittent theta-burst stimulation)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Istanbul Medeniyet University
Healthy
The Effect of Intermittent Theta Burst Stimulation on Motor Learning in Healthy Adults
This study investigates the effect of different application frequencies of intermittent theta burst stimulation on motor learning in healthy adults.
- Trial name
- NCT05073016
- Testing
- neuromodulation, motor learning training
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Schizophrenia
Intermittent Theta Burst Stimulation of the Precuneus
The purpose of the study is to compare the effectiveness of stimulation of the left precuneus by intermittent Theta Burst Stimulation to placebo stimulation on the severity of schizophrenia symptoms.
- Trial name
- Stim-TISiTBS (NCT06142422)
- Testing
- stimulation device
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Healthy Young Adult, Neurophysiology
Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- KME-TBS (NCT06799260)
- Testing
- Ketone Monoester (KME), iTBS, cTBS
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Treatment-resistant Depression (TRD), Major Depression
Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Treatment-resistant depression (TRD) is a major clinical challenge affecting a substantial proportion of patients with major depressive disorder who do not adequately respond to conventional antidepressant treatments.
- Trial name
- TRD-BIOTMS (NCT07673913)
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Parkinsonism, Transcranial Magnetic Stimilation
Clinical Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation With Different Modes on Parkinson's Disease
TMS regulates cortical excitability through electromagnetic induction, with low-frequency stimulation suppressing and high-frequency stimulation enhancing excitability.
- Conditions
- Parkinsonism, Transcranial Magnetic Stimilation, Intermittent Theta Burst Stimulation, Primary Motor Cortex
- Trial name
- NCT07176091
- Testing
- High-dose iTBS treatment group, Low-dose iTBS treatment group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Autism Spectrum Disorder
The Therapeutic Effects of Intermittent Theta Burst Stimulation in Autism Spectrum Disorder
The investigator would like to investigate the impact of theta burst stimulation over right inferior frontal gyrus in autism spectrum disorder
- Trial name
- NCT04987749
- Testing
- intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Ischemic, Aphasia
pBFS-guided iTBS Over the Superior Temporal Gyrus for Aphasia After Ischemic Stroke
The objective of this trial is to evaluate the effectiveness and safeness of intermittent Theta Burst Stimulation (iTBS) over the left Superior Temporal Gyrus (STG), guided by personalized Brain Functional Sector (pBFS)…
- Trial name
- NCT05929534
- Testing
- active intermittent Theta Burst Stimulation
- Volunteers
- 40 people
- Sponsor
- Changping Laboratory
Neuromodulation
Optimization of ITBS for Depression
Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as…
- Trial name
- NCT06464445
- Testing
- Monophasic iTBS, Biphasic iTBS, Monophasic-Long iTBS
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Depression
Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression
This is a randomized, multi-center, open-label study in which patients with depression who responded to an open-label treatment with intermittent theta burst stimulation (iTBS) will receive this procedure as maintenance therapy.
- Trial name
- PROTECT (NCT05732311)
- Testing
- intermittend theta burst stimulation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Berthold Langguth, MD, Ph.D.
Depression, Major Depressive Disorder
Left vs. Right Non-Inferiority Trial
The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).
- Conditions
- Depression, Major Depressive Disorder, Major Depressive Episode
- Trial name
- LeRNIT (NCT04999553)
- Testing
- Repetitive Transcranial Magnetic Stimulation, Intermittent Theta Burst Stimulation (iTBS), Low Frequency Right (LFR)
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- University of British Columbia
Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant…
- Conditions
- Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode, Treatment Resistant Depression
- Trial name
- NCT05849402
- Testing
- Active Comparator: Active aiTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University