Clinical trials: Intercostal Nerve Block, open to volunteers
Autonomic Nerve Block
Sternotomy PIFB Block in Open Heart Surgery
The purpose of this study is to evaluate if the use of a bilateral nerve block with a local anesthetic (ropivacaine), as part of a standard of care pain control regimen (called multimodal analgesia [MMA]), has a favorable effect…
- Trial name
- NCT06233318
- Testing
- Pecto-intercostal Fascial Block with 20 ml of 0.35% ropivacaine, Pecto-intercostal Fascial Block with normal saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Ohio State University
Postoperative Pain, Nerve Block
Investigation of the Effects of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block on Perioperative Analgesia Management in Patients Scheduled for Mastectomy
This study aims to evaluate and compare the analgesic efficacy of two ultrasound-guided regional anesthesia techniques, the serratus anterior plane (SAP) block and the serratus posterior superior intercostal plane (SPSIP) block…
- Conditions
- Postoperative Pain, Nerve Block, Mastectomy, Patient Outcome Assessment
- Trial name
- NCT07510269
- Testing
- SAP Block, SPSIP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Uludag University
Chronic Postoperative Pain, Chronic Post-Sternotomy Pain
Parasternal Intercostal Nerve Block and Chronic Pain After Cardiac Surgery
Chronic post-sternotomy pain is a common but under-recognised complication of cardiac surgery, reported in roughly 11 to 56 percent of patients and capable of persisting for years after the operation.
- Conditions
- Chronic Postoperative Pain, Chronic Post-Sternotomy Pain, CABG, Sternotomy
- Trial name
- PINB-CPSP (NCT07818512)
- Testing
- Ultrasound-Guided Parasternal Intercostal Nerve Block, Bupivacaine 0.25%
- Volunteers
- 132 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS)
Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery
Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or…
- Conditions
- Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS), Erector Spinae Plane Block, Intercostal Nerve Block
- Trial name
- NCT07535697
- Testing
- Anesthesiological, Ultrasound-Guided "Erector Spine Plane Block" (ESPB), Surgical, Thoracoscopically-Guided "Intercostal Nerve Block" (ICNB)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sana Klinikum Offenbach
Postoperative Pain, Acute, Lung Cancer
Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine
This randomized controlled trial evaluates the analgesic effects of liposomal bupivacaine compared to bupivacaine hydrochloride in intercostal nerve block for patients undergoing thoracoscopic lung surgery.
- Trial name
- NCT07134660
- Testing
- Liposomal Bupivacaine intercostal nerve block, Bupivacaine Hydrochloride intercostal nerve block, Standard Postoperative Analgesia
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Video-assisted Thoracoscopic Surgery (VATS), Postoperative Pain
Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Video-assisted Thoracoscopic Pneumonectomy
Revised-Paravertebral Nerve Block (r-PVB) is performed right after induction of general anesthesia and before lateral positioning of surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Postoperative Pain, Quality of Recovery, Lung Diseases
- Trial name
- r-PVB-1 (NCT07567950)
- Testing
- Revised-Paravertebral Nerve Block, Control
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Benign Gallbladder Disease, Laparoscopic Cholecystectomy
Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Laparoscopic Cholecystectomy
After laparoscopic cholecystectomy, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the…
- Conditions
- Benign Gallbladder Disease, Laparoscopic Cholecystectomy, Postoperative Pain, Quality of Recovery
- Trial name
- REVISED-PVB II (NCT07566819)
- Testing
- Revised-Paravertebral Nerve Block
- Volunteers
- 250 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Lobectomy
Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection
Combining tegileridine PCIA with ICNB targeting peripheral nerves, may constitute an ideal analgesic model with complementary advantages.
- Trial name
- NCT07386626
- Testing
- Tegileridine, Intercostal Nerve Block, Sufentanil
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Tongji Hospital
Thoracic Surgery, Glycemic Variability
Comparison of Liposomal Bupivacaine Paravertebral Nerve Block Versus Intercostal Nerve Block on Postoperative Glycemic Variability in Patients Undergoing Minimally Invasive Pulmonary Resection: A Randomized Controlled Non-Inferiority Trial
In this randomized controlled non-inferiority trial, we will test whether liposomal bupivacaine intercostal nerve block is non-inferior to paravertebral nerve block for the coefficient of variation (CV) of glucose during the 0…
- Trial name
- NCT07754916
- Testing
- Paravertebral nerve block, Intercostal nerve block
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Xiangya Hospital of Central South University
Rib Fractures
INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous/oral inpatient and oral outpatient) alone for patients with multiple…
- Trial name
- NCT05642026
- Testing
- Ropivacaine, Non steroidal anti-inflammatory drug and opioids
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Zachary Warriner
Acute Pain, Post Operative Analgesia
Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy
Postoperative pain management is crucial for patients undergoing mastectomy for breast cancer. Regional analgesia techniques, such as the Thoracic Paravertebral Block (TPVB), are commonly used to reduce pain and opioid…
- Conditions
- Acute Pain, Post Operative Analgesia, Post Operative Pain, Acute, Breast Cancer
- Trial name
- PECS-TPVB (NCT07738770)
- Testing
- Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB)
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Dharmais National Cancer Center Hospital
Postoperative Pain, Cardiac Surgery
Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery
Median sternotomy is commonly used in cardiac surgery and is often associated with significant postoperative pain. Poor pain control after sternotomy may increase opioid use, delay mobilization, prolong extubation time, and…
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Pain After Cardiac Surgery Via Median Sternotomy
- Trial name
- SPARE-CABG (NCT07498946)
- Testing
- Thoracic paravertebral block (TPVB), Bilateral Deep Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gaziantep City Hospital
Lung Cancer (Diagnosis)
Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1
The goal of this clinical trial is to assess how the location of local anesthetic medication affects pain control capabilities in adult patients undergoing thoracic(chest)-only minimally invasive surgery.
- Trial name
- CALMS-1 (NCT07254650)
- Testing
- Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Pain, Shoulder Arthroscopy
Interscalene Brachial Plexus Block Versus Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder Surgery
Arthroscopic shoulder surgery is associated with moderate to severe postoperative pain that may delay recovery and rehabilitation.
- Trial name
- SISA (NCT07668648)
- Testing
- Interscalene Brachial Plexus Block, Serratus Posterior Superior Intercostal Plane Block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Stoma Closure, Postoperative Pain
Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure
After stoma closure, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed…
- Conditions
- Stoma Closure, Postoperative Pain, Quality of Recovery
- Trial name
- r-PVB III (NCT07571902)
- Testing
- Revised-Paravertebral Nerve Block
- Volunteers
- 250 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer Surgery Pain
The Effect of Nerve Blocks on Analgesia in Breast Cancer Surgery
Postoperative pain following modified radical mastectomy remains a significant clinical concern and may adversely affect patient recovery, opioid consumption, and overall patient satisfaction.
- Trial name
- breast surgery (NCT07601490)
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Serratus anterior plane block (SAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pain; Cancer, Hepatectomy
Ultrasound Guided External Oblique Intercostal Plane Block Versus Erector Spinae Block for Post Hepatectomy Pain
Management of acute post-operative pain has received keen attention in recent years with considerable concurrent advancement in the field.
- Conditions
- Pain; Cancer, Hepatectomy, Nerve Block
- Trial name
- NCT07337330
- Testing
- Ultrasound guided external oblique intercostal (EOI) plane block, Ultrasound guided erector spinae block
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute, Egypt
Coronary Arterial Disease, Coronary Artery Bypass Grafting (CABG) Surgery
ESPB vs SPSIP for Postoperative Analgesia After CABG
This prospective, randomized, active-controlled, double-blind, parallel-group study compares the postoperative analgesic efficacy and safety of ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) versus bilateral…
- Conditions
- Coronary Arterial Disease, Coronary Artery Bypass Grafting (CABG) Surgery, Postoperative Pain Management
- Trial name
- ESP-SPSIP-CABG (NCT07388745)
- Testing
- Ultrasound-guided Erector Spinae Plane Block (ESPB), Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Kutahya Health Sciences University
Lung Transplantation, Pain Management
The Effect of Bupivacaine Liposomes on Postoperative Pain in Lung Transplant Patients After Intercostal Nerve Block: a Randomized Controlled Study
The goal of this clinical trial is to evaluate the efficacy and safety of liposomal bupivacaine for postoperative analgesia in adult patients undergoing lung transplantation.
- Conditions
- Lung Transplantation, Pain Management, Liposomal Bupivacaine
- Trial name
- NCT07641647
- Testing
- LB/BH intercostal nerve block, BH intercostal nerve block
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pulmonary Dysfunction, Median Sternotomy Recovery
FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy
Background and Rationale: Open-heart surgery via a median sternotomy is associated with severe acute postoperative pain. This pain can impair a patient's ability to take deep breaths and cough effectively which increases the risk…
- Conditions
- Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
- Trial name
- FROST-STERN (NCT07637370)
- Testing
- Intercostal Nerve Cryoablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey