Clinical trials: Intensive Care Unit Syndrome
Genetic Predisposition to Disease, Hyperglycemia
TCF7L2 Polymorphisms Influence on Glycemic Control in ICU Patients With Organ Failure
This study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of TCF7L2 gene and the risk of developing hyperglycemia during Intensive care unit stay
- Conditions
- Genetic Predisposition to Disease, Hyperglycemia, Intensive Care Unit Syndrome, Multiple Organ Failure
- Trial name
- READIAB-G4 (NCT03055169)
- Testing
- genetic analysis, blood and stools samples
- Where
- 5 sites in France
- Volunteers
- 994 people
- Sponsor
- University Hospital, Lille
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
Anemia, Mechanical Ventilation
Anemia and Duration of Mechanical Ventilation
In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality.
- Conditions
- Anemia, Mechanical Ventilation, Critically Ill, Intensive Care Unit
- Trial name
- NCT05382065
- Where
- Thailand
- Volunteers
- 236 people
- Sponsor
- Mahidol University
Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment
Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)
The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors.
- Conditions
- Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment, Post Intensive Care Unit Syndrome, Virtual Reality Cognitive Training
- Trial name
- NCT07496255
- Testing
- VR-based cognitive training program, VR-based attention control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Post Intensive Care Unit Syndrome
Web-based Follow-up to Former ICU Patients
This study evaluates if a web-based 1-year programme is a useful method for follow-up intensive care survivors with short ICU-stay.
- Trial name
- WIVA (NCT04317144)
- Testing
- Web-based follow-up programme., No follow-up
- Where
- Sweden
- Volunteers
- 330 people
- Sponsor
- Uppsala University
Intensive Care Unit Syndrome
Study on the Priorities of Patients Admitted to Intensive Care
The goal of this observational study is to learn about the priorities of patients admitted to intensive care units (ICUs) who have a life-threatening condition, as well as the priorities assumed by their designated relatives and…
- Trial name
- PRIOREA (NCT07417592)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Intensive Care Unit Syndrome
Cerebral Perfusion Variation During Blood Pressure Changes in ICU
The risk associated with arterial hypotension during anesthesia for intensive care sedation has been demonstrated, but the threshold at which consequences for perfusion of one or more organs appear varies according to the…
- Trial name
- DELTAPAMREA (NCT05804773)
- Testing
- Non-invasive Measurement of cerebral blood velocity in the middle cerebral artery by transcranial pulsed Doppler (TCD) (Mean velocity, Vm, cm/s)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Intensive Care Syndrome (PICS), Symptom Burden
Post-Intensive Care Syndrome and Associated Symptom Burden Among Danish ICU Survivors
The study aims to estimate the prevalence of post-intensive care syndrome (PICS) 12 months after ICU admission among adult ICU survivors in Denmark and to describe how this prevalence is distributed across the physical…
- Conditions
- Post-Intensive Care Syndrome (PICS), Symptom Burden, Intensive Care Unit (ICU) Patients
- Trial name
- PICAS-DK (NCT07373561)
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Deglutition Disorders, Intensive Care Unit Syndrome
Removal of Nasogastric Feeding Tube Post Extubation in ICU : a Prospective Randomized Trial
Post-extubation dysphagia (PED) is a frequent but still underestimated condition in the intensive care units (ICU). In the international literature, the manifestations and consequences of PED lead to intra- and post-intensive…
- Conditions
- Deglutition Disorders, Intensive Care Unit Syndrome, Swallowing Disorder, Feeding or Eating Disorder
- Trial name
- FIRST (NCT05795569)
- Testing
- Nasogastric Tube removal during extubation, Yale Swallow Protocol, Classif Nasogastric Tube Management
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sepsis, Post Intensive Care Unit Syndrome
Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.
The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU…
- Conditions
- Sepsis, Post Intensive Care Unit Syndrome, Critical Illness, Microbiome Dysbiosis
- Trial name
- PAM-ICU (NCT07295353)
- Testing
- Pasteurized Akkermansia muciniphila
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Pain, Post Intensive Care Unit Syndrome
The Post-ICU Pain Study
BACKGROUND: ICU survivors may experience serious psychological, physical and cognitive impairments following ICU admission, collectively termed Post Intensive Care Syndrome (PICS).
- Conditions
- Chronic Pain, Post Intensive Care Unit Syndrome, Quality of Life, Pain Disorder
- Trial name
- PIP (NCT07180407)
- Where
- 4 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Positive End-expiratory Pressure (PEEP), Oxygenation Index
Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric…
- Conditions
- Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury
- Trial name
- NCT07233304
- Testing
- Alveolar Opening Maneuver and PEEP Titration (AOM+P)
- Where
- Argentina
- Volunteers
- 143 people
- Sponsor
- Hospital de Alta Complejidad en Red
Intensive Care Unit Syndrome, Hypercapnia
Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg.
- Conditions
- Intensive Care Unit Syndrome, Hypercapnia, Acute Respiratory Failure
- Trial name
- YETI (NCT04304339)
- Testing
- Hypercapnic respiratory failure
- Where
- 3 sites in France
- Volunteers
- 862 people
- Sponsor
- French Society for Intensive Care
Intensive Care Units, ARDS, Human
Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 Infections
Severe Covid-19 (Coronavirus Disease 2019) infections generate major but inappropriate production of cytokines and, in some cases, generate anti-IFN (Interferon) auto-antibodies, inducing acute respiratory distress syndrom…
- Conditions
- Intensive Care Units, ARDS, Human, Covid19
- Trial name
- CovidEP (NCT04751643)
- Testing
- Therapeutic plasma exchange : 3 sessions in 3 consecutive days (day 1 to day 3), Usual treatments in intensive care unit according to the current state of knowledge
- Where
- 8 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Distress Syndrome (ARDS), Hypoxemia
Early Prone Positioning and Clinical Outcomes in Non-Intubated Acute Respiratory Distress Syndrome (ARDS) Patients
This study aimed to evaluate the effectiveness of early prone positioning in improving clinical outcomes among non-intubated patients with Acute Respiratory Distress Syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypoxemia, Respiratory Failure, Non-Intubated Patients
- Trial name
- EPP-ARDS (NCT07133022)
- Testing
- Early Prone Positioning Protocol, Standard ICU Care
- Where
- Palestinian Territories
- Volunteers
- 100 people
- Sponsor
- Loai Muawiah Zabin
Critical Illness, Communication
Communication With Mechanically Ventilated Intensive Care Patients
The overarching aim of this multicenter study is to develop a multimodule training intervention (COMMEC-ICU) for nurses working in ICUs, to increase nurses skills and knowledge and then improve communication for mechanically…
- Conditions
- Critical Illness, Communication, Intensive Care Unit Syndrome
- Trial name
- COMMEC-ICU (NCT06977555)
- Testing
- Communication Course and skills training
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Adult Disease, Intensive Care Unit Syndrome
Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
For patients undergoing mechanical ventilation, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased…
- Conditions
- Adult Disease, Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Delirium
- Trial name
- NCT03172897
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University First Hospital
Intensive Care Unit Syndrome, Prediction
Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study
This project intends to track and evaluate whether post-ICU syndrome will occur 7 days, 1 month, 3 months and 6 months after ICU patients are transferred out of the ICU through a longitudinal study, apply the latent category…
- Conditions
- Intensive Care Unit Syndrome, Prediction, Cognitive Impairment, Sleep Disorder
- Trial name
- NCT06427265
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
COVID-19 Pandemic, Intensive Care Unit Syndrome
Post-ICU Follow-up Study in Covid-19 Patients
A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
- Conditions
- COVID-19 Pandemic, Intensive Care Unit Syndrome, Delirium
- Trial name
- NCT05299346
- Testing
- Follow up
- Where
- Sweden
- Volunteers
- 793 people
- Sponsor
- Sahlgrenska University Hospital