Clinical trials: Intensive Care Unit Acquired Weakness
Intensive Care Unit Acquired Weakness, Critical Illness
Locomotor Muscle Oxygenation and Activation During Acute Interval Compared to Constant-load Bed-cycling Exercise
Up to 60% of patients admitted to the Intensive Care Unit (ICU) with a prolonged stay in the ICU develop complications such as intensive care unit acquired weakness (ICUAW) characterized by limb and respiratory muscle weakness.
- Trial name
- NCT05279547
- Testing
- Constant-load bed-cycling exercise, Interval bed-cycling exercise
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
ICU Acquired Weakness, Intensive Care Neuropathy
Predictive Validity of the Chelsea Critical Care Physical Assessment Tool (CPAx) for Regaining Autonomy Three Months After ICU Discharge
This single-center observational study aims to explore the relationship between the CPAx score (Chelsea Critical Care Physical Assessment Tool), measured at ICU discharge, and the 6-minute walk test (6MWT) distance performed 3…
- Trial name
- CPAx-Predict (NCT07167121)
- Testing
- CPAx
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Intercommunal Elbeuf-Louviers-Val de Reuil
Intensive Care Unit Acquired Weakness
Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.
Critically ill patients are known to develop serious nutritional deterioration during the course of their disease. They develop, from the beginning, a multifactorial protein malnutrition that relates to a poor clinical course and…
- Trial name
- FISIO (NCT05918757)
- Testing
- Protein dose 1.5 g/kg/day, Protein dose 1.0 g/kg/day
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Critical Care Medicine and Coronary Units
Thyroid Abnormalities, ICU Acquired Weakness
Association Between Thyroid Dysfunction and Intensive Care Unit Acquired Weaknesss
Intensive care unit-acquired weakness (ICU-AW) is the most common neuromuscular impairment in critically ill patients. It affects more than 50 % of patients in the intensive care and is related to many problems as difficult…
- Trial name
- NCT04313101
- Testing
- withdrawl of blood samples for thyroid function testing
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Ain Shams University
ICU-acquired Weakness
Evidence-based, Customized, Motion-recognition Rehabilitation System Development for Bed-ridden Patients - Validation of Effectiveness: Rehabit: Swim
This pilot study aims to evaluate the efficacy, safety, feasibility, and user satisfaction of "Rehabit: swim," a customized, evidence-based, motion-recognition-based rehabilitation exergame designed for hospitalized patients with…
- Trial name
- NCT07896057
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
ICU Acquired Weakness
Risk Factors of ICU-acquired Weakness
We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score < 48 out of a maximal…
- Trial name
- ICU-AW (NCT04932330)
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
ICU Acquired Weakness
Effect of the "Sitting Out of Bed in an Arm-chair Position" in ICU on Functional Recovery Among Ventilated Patients
Chair positioning is one of a series of early mobilization techniques. At present, this technique, which involves moving a patient out of the resuscitation bed, can be performed passively or actively.
- Trial name
- STORM (NCT06973746)
- Testing
- sitting out of bed in an arm-chair position
- Where
- 11 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Critical Illness, Nutritional and Metabolic Disease
Diarrhea and Stipsis in Critically Ill Patients (NUTRITI)
This study prospectively observed the complications intended as diarrhea or sti-sis that critically ill patients developed within 7 days after ICU admission.
- Conditions
- Critical Illness, Nutritional and Metabolic Disease, Nutritional Deficiency, ICU Acquired Weakness
- Trial name
- NUTRITI (NCT05473546)
- Testing
- ARTIFICIAL NUTRITION
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Sepsis
Dysfunctions of Human Muscle Stem Cells in Sepsis
Severe critical illness is often complicated by Intensive Care Unit - Acquired Weakness (ICU-AW), which is associated with increased in and post-ICU mortality, with delayed weaning from mechanical ventilation and with long-term…
- Trial name
- DISCUSS (NCT02789995)
- Testing
- Human biological samples
- Where
- 7 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Critical Illness, Respiratory Failure
Treatment of Muscle Weakness in Critically Ill Patients
Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness.
- Conditions
- Critical Illness, Respiratory Failure, Myopathy, Weakness
- Trial name
- NCT02247895
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gerald Supinski
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Intensive Care Unit Acquired Weakness
The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
In this study, the effect of inspiratory muscle training on diaphragmatic functions will be investigated radiologically in mechanically ventilated patients.
- Trial name
- NCT05303623
- Testing
- Conventional Physiotherapy, Conventional Physiotherapy+ inspiratory muscle training, inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Demiroglu Bilim University
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Peripheral Muscle Strength
Study of Intensive Care Unit (ICU)-Acquired Weakness (Handgrip Strength Study)
To better understand ICU-acquired weakness in patients requiring mechanical ventilation in the Intensive Care Unit.
- Trial name
- NCT00702000
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Naeem Ali, MD
ICU-acquired Muscle Weakness
Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICU
Early mobilization (from the first day if possible), first passive and then passive and active, is recommended for critically ill patients in whom it reduces the duration of mechanical ventilation, the length of hospital stay…
- Trial name
- PROMOREA1 (NCT02185989)
- Testing
- Early electrical stimulation and early leg bicycling added to early standard rehabilitation
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Intensive Care Unit (ICU) Acquired Weakness (ICU - AW), Acquired Brain Injury (Including Stroke)
Functional Electrical Stimulation to Treat Critical Neuromyopathy After Severe Stroke: a Pilot Study.
This study aims to evaluate the effectiveness of physiotherapy treatment combined with functional electrical stimulation (FES) in a small group of patients with severe acquired brain injury (SABI) of vascular origin and with a…
- Trial name
- RISE (NCT07130929)
- Testing
- Functional Electrical Stimulation, Conventional physiotherapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critical Illness, Mechanical Ventilation
Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients
Critically ill patients who require mechanical ventilation frequently experience rapid loss of muscle mass and physical function during their stay in the intensive care unit (ICU).
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit-Acquired Weakness, Physical Rehabilitation in the Intensive Care Unit
- Trial name
- NCT07361419
- Testing
- Supine Physiotherapy Session
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Extremadura
Intensive Care Unit Acquired Weakness, Critical Illness
Effects of Ketosis on Muscle Kinetics and Signaling During Critical Illness.
Background: Patients with critical illness in the intensive care unit (ICU) experience marked skeletal muscle weakness, muscle atrophy and disability in physical function, commonly termed ICU-acquired weakness (ICU-AW).
- Trial name
- KETO-ICU (NCT05074862)
- Testing
- KetoneAid KE4 Pro Monoester
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital