Clinical trials: Intensive Care, open to volunteers
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Heart Failure, ICUAW
Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study
Critically ill patients in intensive care units (ICUs) are exposed to a wide range of complications that can affect long-term morbidity and mortality.
- Trial name
- ICU-HF (NCT07094425)
- Testing
- transthoracic echocardiography
- Where
- 2 sites in Austria, Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Infant, Premature, Diseases, Premature Birth of Newborn
Elevated Midline Positioning During Diaper Change in Preterm Infants
Diaper changing is one of the most frequent routine care procedures in the neonatal intensive care unit (NICU) and is known to cause physiological instability and behavioral stress responses in preterm infants.
- Conditions
- Infant, Premature, Diseases, Premature Birth of Newborn, Pain
- Trial name
- NCT07865897
- Testing
- 30-Degree Elevated Midline Positioning, Standard Lateral Position Diaper Change
- Volunteers
- 80 people
- Sponsor
- Akdeniz University
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Clinical Implementation, Standardized Tube Feeding Care
Clinical Implementation of the Group Standard for Enteral Feeding Care in Critically Ill Children
This study aims to evaluate the feasibility and effectiveness of the " Standard for Enteral Feeding Care in Critically Ill Pediatric Patients " (T/CNAS 45-2024) in a multicenter setting.
- Conditions
- Clinical Implementation, Standardized Tube Feeding Care, Enteral Nutrition
- Trial name
- NCT07441746
- Testing
- Evidence-based tube feeding care, Routine Enteral Feeding Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Trauma Injury
Retrospective Assessment of Referral of a Major Trauma Patient
The aim of this study is to find out whether major trauma patients from the Val d'Oise are referred to the appropriate trauma centre for their care and to assess the quality of triage within the Val d'Oise department.
- Trial name
- SAMU-TRAUMAS (NCT06551350)
- Testing
- Data Collection
- Where
- France
- Volunteers
- 461 people
- Sponsor
- Hôpital NOVO
Psychological Disorder, Critical Illness
Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Studies in hospitalized patients have shown that a large percentage of them consider religion or spirituality to be an important factor in enabling them to cope with a serious illness.
- Trial name
- NCT06048783
- Testing
- Program of systematic and periodic spiritual accompaniment and care
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Craniopharyngioma
A Comparative Study Evaluating the Impact of Intensive Dietary Care on Weight Change and Biological Parameters in Patients Who Underwent Surgery for Craniopharyngioma During the First Postoperative Year
Craniopharyngiomas are rare benign tumors that develop in the hypothalamic-pituitary region. Their prevalence is estimated at approximately 1 in 50,000 people in France.
- Trial name
- CRANIODIET (NCT07835165)
- Testing
- Intensive dietary care
- Volunteers
- 75 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Quality Indicators
Evaluation of Quality Indicators in Patients Receiving Intensive Care and Their Influence on Outcome Indicators and Economic Indicators
The aim of the study is to identify and evaluate incentive mechanisms for the implementation of quality-relevant care processes.
- Trial name
- EQUINOK (NCT07501494)
- Where
- Germany
- Volunteers
- 35,000 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) - "HemodynamECMOnitoring-VA Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593756
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
ICU Delirium
Modified Hospital Elder Life Program at Intensive Care Unit
Delirium, a form of acute brain dysfunction, occurs in up to 81% of patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- mHelp@ICU (NCT06054828)
- Testing
- mHELP@ICU
- Where
- Taiwan
- Volunteers
- 266 people
- Sponsor
- National Taiwan University Hospital
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Post Intensive Care Syndrome
Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS).
- Trial name
- FICUF (NCT05984069)
- Testing
- observational prospective data collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ventilator Associated Pneumonia ( VAP)
Pre-clinical Diagnosis Using Integrated Microbial and Host Response Signatures to Improve Outcomes From Ventilator-associated Pneumonia in Critically Ill Children
Ventilator-associated pneumonia (VAP), defined as pneumonia occurring 48 hours after initiation of invasive mechanical ventilation, is insidious in onset and severe in consequence.
- Trial name
- VAP-Dx (NCT07026656)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Cambridge
Neonatal Seizure
Monitoring Key Activity and Physiology of Neonates in Intensive Care
To optimise and evaluate a novel non-contact physiological monitoring system in the neonatal intensive care unit (NICU)
- Trial name
- Meerkat (NCT04831242)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Subarachnoid Hemorrhage
Impact of Early Mobilization on SAH Patients Physiological Parameters
The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage.
- Trial name
- MOBALPAH (NCT06286683)
- Testing
- lung ultrasound, Transcranial Doppler, near-infrared spectroscopy (NIRS)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Blood Sugar
Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit
Researchers at the Department of Intensive Internal Medicine and the Department of Endocrinology and Diabetology will conduct a study to verify the accuracy and safety of the new Syai Tag system for continuous glucose monitoring…
- Conditions
- Diabetes Mellitus, Blood Sugar, Sepsis, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT07448805
- Testing
- continuous glucose monitor
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor