Clinical trials: Intensive Care
Acute Dyspnea
Implementation of Mobile Intensive Care Unit Ultrasound Based Management for Acute Dyspnea
This multicentre, cluster-randomised, stepped-wedge clinical trial aims to assess whether an intervention designed to implement an ultrasound-guided pre-hospital care pathway for the management of acute dyspnea would improve the…
- Trial name
- IMICU2-Dyspnea (NCT07852364)
- Testing
- Ultrasound pre-hospital care
- Where
- 11 sites in France
- Volunteers
- 800 people
- Sponsor
- Central Hospital, Nancy, France
Oral Feeding Outcomes, Neurodevelopment Outcome
Impact of Hospital to Home: Optimizing Preterm Infant Environment for Surgical Neonates and Their Parents (H-HOPE)
Infants born with congenital defects may require major surgery in the neonatal period. These infants are at risk for neurodevelopmental impairments.
- Trial name
- H-HOPE (NCT07372898)
- Testing
- H-HOPE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Severely Traumatized Patients in Emergency Wards
Interest of the Ultrasound Guidance for the Laying of Femoral Arterial and Venous Catheters in Intensive Care Unit
The femoral approach is the preferred vascular access for the set-up of emergency catheters in severely traumatized patient. This location combines simplicity and speed of installation, it allows the simultaneous set-up of…
- Trial name
- ECHOGUIDE (NCT02820909)
- Testing
- venous and arterial catheter set-up using ultrasound guidance, Anatomical guidance.
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Hospices Civils de Lyon
Nervous System Diseases, Respiratory Tract Diseases
Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Oxygen administration is a common practice in intensive care units, although concern is growing about oxygen toxicity. The aim of the study is to access whether a rigorous maintenance of a state of normal oxygenation in…
- Conditions
- Nervous System Diseases, Respiratory Tract Diseases, Cardiovascular Diseases, Immune System Diseases
- Trial name
- OXYGEN-ICU (NCT01319643)
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- University of Modena and Reggio Emilia
Chronic Disease
Intensive Management of At-risk Patients
The purpose of this study is to assess if intensive management of at-risk participants, utilizing longitudinal patient tracking, proactive outreach, multidisciplinary action planning and careful outcomes monitoring, will lead to…
- Trial name
- NCT04456725
- Testing
- Intensive management, Control
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- CareMore Health, San Bernardino
Patient Activation, Mobilization
Evaluation of the Effect of Robot-assisted Early Mobilization - Project MobiStaR
Within the MobiStaR project the adaptation of procedures in an intensive care unit combined with the use of this robotic system will create the conditions to increase the mobilization rate of critically ill intensive care…
- Conditions
- Patient Activation, Mobilization, Robotics
- Trial name
- MobiStaR (NCT05071248)
- Testing
- VEMO (Reactive Robotics GmbH)
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Traumatic Brain Injury
Role of Combined Therapy of Propranolol and Gabapentin in Paroxysmal Sympathetic Hyperactivity in Traumatic Brain Injury
Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that comprises a series of signs and symptoms reflecting exacerbated sympathetic activity, including arterial hypertension, fever, tachycardia, generalized perspiration…
- Trial name
- NCT05427474
- Testing
- Propranolol , gabapentin
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Zagazig University
Muscle Weakness
Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness
Assessment of Effectiveness of combined high protein intake with early physical exercise by ultrasound measurement of rectus femoris muscle thickness in Intensive Care Unite mechanically ventilated patients.
- Trial name
- NCT05877989
- Testing
- Amino Acid, Physical exercise
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Covid19, Pediatric ALL
Pediatric Intensive Care and COVID-19
In this prospective longitudinal cohort the investigators reported the clinical, and biological characteristics of all critically ill patients admitted in the pediatric intensive care unit (PICU) of Bicêtre Hospital during the…
- Conditions
- Covid19, Pediatric ALL, Infection, Critical Illness
- Trial name
- CLOVIS (NCT04544878)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Critically Ill Severe Bronchiolitis
Helmet Continuous Positive Airway Pressure Support for Severe Bronchiolitis in PICUs
Binary randomized peep level of Helmet CPAP (1-0). The first patient enrolled will be assign to treatment 1 (10 cmH2O peep level), independently from its BSS.
- Trial name
- NCT02977585
- Testing
- 10 cmH2O peep
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Obesity, Life Style
Intensive Lifestyle Interventions to Overweight and Obese Patients in Primary Care
The goal of this clinical trial is to compare in the effect of different lifestyle interventions in overweight and obese participants.
- Conditions
- Obesity, Life Style, Lifestyle, Sedentary
- Trial name
- NCT06321809
- Testing
- intensive lifestyle
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people
- Sponsor
- Duygu Ayhan Baser
Acute Myeloid Leukemia (AML)
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML
Ziftomenib is an investigational drug in development for the treatment of patients with acute myeloid leukemia (AML) with eligible genetic alterations.
- Trial name
- NCT07007312
- Testing
- Ziftomenib, Venetoclax, Azacitidine (AZA)
- Where
- 136 sites in United States, Australia and 15 more
- Volunteers
- 1,300 people
- Sponsor
- Kura Oncology, Inc.
Sleep Quality
Effectiveness of Ear Plug, Eye Mask and Ocean Sound on Sleep Quality Among ICU Patients
The study evaluates the effectiveness of ear plug, eye mask and ocean sound on sleep quality among ICU patients. 60 patients were randomly allocated to group 1 and group 2 by lottery method i.e 30 in each group.
- Trial name
- NCT03215212
- Testing
- eye mask, ocean sound, ear plug
- Volunteers
- 60 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Sepsis at Intensive Care Unit
Validation of a Urinary Biomarker as Diagnostic Tool for AKI in Sepsis
BACKGROUND: Early diagnosis and prognostication of acute kidney injury in patients with sepsis is key to further our understanding this disease and in the evaluation of new interventions for this condition.
- Trial name
- NCT01981993
- Testing
- Urinary proteomic analysis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Alarm Fatigue
Design and Validation of a German Language Questionnaire for Measuring Alarm Fatigue in Intensive Care Units
False-positive and non-actionable alarms can lead to staff desensitization ("alarm fatigue") and thus patient endangerment. With this study the investigators create a basic tool to survey alarm fatigue of intensive care staff…
- Trial name
- alarmZen1 (NCT04994600)
- Testing
- Reduces number of question items
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- Charite University, Berlin, Germany
Cerebral Palsy
Study of Parental Stress and Care Consumption Until 24 Months Corrected Age of Infants at a High Risk of Developmental Delay, After Discharge From Neonatal Intensive Care
Cerebral palsy (CP) is the leading cause of motor disability in children, affecting 125,000 people in France and with 1800 new cases per year.
- Trial name
- DeStreSs (NCT05233371)
- Testing
- Parenting Stress Index (PSI), Collection of health care consumption, Assessment of parent satisfaction
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Anemia, Sepsis
Use of Epoetin Alfa and Iron Derisomaltose in Treatment of Anemia in Patients With Sepsis or Septic Shock: a Randomized Controlled Trial
Background Up to 66% of have anemia at the admission to the intensive care unit. This number increases to 95% after 72 hours of hospitalization in the intensive care unit due to illness and iatrogenic blood loss.
- Conditions
- Anemia, Sepsis, Septic Shock
- Trial name
- EpoAid (NCT06670963)
- Testing
- Iron, EPO, 0.9 % NaCl
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Piotr Czempik
X-Rays
Optimization of Bedside Chest X-rays Taken in the Intensive Care Unit by Using Current Software-based Techniques
This study investigates how to utilize an algorithm-based virtual grid in lung imaging in intensive care unit patients. The aim is to compare the radiation dose caused by imaging with a virtual grid and a traditional grid and…
- Trial name
- NCT05025319
- Testing
- X-ray image
- Where
- Finland
- Volunteers
- 500 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Intensive Care Units
ORI2 : ORI for hyperOxia Reduction in ICU
Recently, hyperoxia has been recognized as being potentially deleterious for critically ill patients, with increased duration of mechanical ventilation and even with increased mortality rates.
- Trial name
- ORI2 (NCT02878460)
- Testing
- monitoring with ORI + SpO2, monitoring with SpO2
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers