Clinical trials: Integrated Assessment, open to volunteers
Polycystic Ovary Syndrome
DAISy-PCOS Phenome Study - Dissecting Androgen Excess and Metabolic Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving.
- Trial name
- DAISy-PCOS (NCT03911297)
- Testing
- Women with polycystic ovary syndrome
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
COPD, Chronic Musculoskeletal Pain
The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain
Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology-mediated walking and Tai Chi…
- Trial name
- WATCH for Pain (NCT05701982)
- Testing
- Every Step Counts-Tai Chi, Usual Care
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Health Care Utilization
Evaluation of a Health System Integrated Model for Postpartum Education and Support in Rural Populations
This study was designed to evaluate the implementation of the Nurse Education and Support Team (NEST) Program for postpartum women who reside in 5 rural counties in North Carolina.
- Trial name
- NEST-Rural (NCT06682520)
- Testing
- Postpartum NEST-Rural Program (Hospital based service model)
- Where
- United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Stroke, Spinal Cord Injuries (SCI)
Long-Term Clinical, Health Economic, and Process Evaluation of Intensive Technology-Integrated Motor Rehabilitation in Chronic Neurological Conditions (INTeRAcT-bis)
Rehabilitation remains important in the chronic phase after stroke or spinal cord injury, as meaningful improvements may still be achieved through intensive, goal-directed, and personalized training.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Chronic Disease
- Trial name
- INTeRAcT-bis (NCT07912320)
- Testing
- Intensive rehabilitation programme
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Septic Cardiomyopathy
Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy Using an Integrated Mathematical Model
The goal of this observational study is to evaluate whether a new integrated mathematical model can improve the accuracy of diagnosing septic cardiomyopathy and predicting clinical outcomes in adult patients with suspected septic…
- Trial name
- NCT06793020
- Where
- 2 sites in Lithuania, Poland
- Volunteers
- 100 people
- Sponsor
- Vilnius University
Frail Elderly Patients, Geriatric Syndromes
Improving Care for Frail Older Adults Using a Digital Needs Assessment Tool
The goal of this trial is to evaluate whether a digital needs-assessment tool can improve care planning and outcomes for frail older adults (aged 60 years and above) hospitalized in Singapore.
- Conditions
- Frail Elderly Patients, Geriatric Syndromes, Frail Older Adults
- Trial name
- Frailty (NCT07580690)
- Testing
- Core: SST-informed care planning, Additional telephone calls
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Duke-NUS Graduate Medical School
Bile Duct Carcinoma, Cholangiocarcinoma
Precision Integrated Strategies and Efficacy Evaluation for Biliary Tract Cancers: An Umbrella Platform Study
This study is a prospective, multicenter, open-label, umbrella phase II clinical trial. Based on different multigene expression profiling subtypes and potential molecular characteristics of various pathways, 8 treatment arms and…
- Trial name
- NCT07729917
- Testing
- FGFR Inhibitor, IDH1 mutation inhibitor, KRAS mutation inhibitor
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang University
Older Adults (70 or More) Living at Home With Health and Social Complexity
Evaluation of an Integrated Home Care Model
The demographic shift towards a progressive aging of the population represents an unprecedented challenge for Western societies and for the sustainability of health and social systems.
- Trial name
- ADMIT (NCT07408882)
- Testing
- ADMIT integrated care Program
- Where
- 8 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Parc Sanitari Pere Virgili
Airway Assessment
Personalized Selection of Hyperangulated vs. Macintosh Videolaryngoscope Blades
This study aims to determine whether hyperangulated blades have a higher intubation success rate than Macintosh blades in patients undergoing general anesthesia, and to identify patient subgroups in which hyperangulated blades…
- Trial name
- HAVL (NCT07370883)
- Testing
- Macintosh group, hyperangulated group
- Volunteers
- 524 people
- Sponsor
- Seoul National University Hospital
Bite, Orthodontics
Evaluation of a Novel Lip Bumper With Integrated Distal Shoe Appliance in Preventing Second Molar Impaction in Children With Anterior Deep Bite
The goal of this clinical trial is to evaluate the effectiveness of a novel lip bumper with an integrated distal shoe in preventing second molar impaction in children aged 8-10 years with anterior open bite during the mixed…
- Trial name
- Novel Lip Bump (NCT07015385)
- Testing
- Lip Bumper with Integrated Distal Shoe, Conventional Lip Bumper
- Volunteers
- 40 people
- Sponsor
- Dar Al Uloom University
Stroke, Brain Ischemia
A Novel Rural Integrated Care and Early Prevention Model for Older Adults at High Risk of or Living With Stroke in China
This cluster randomized controlled trial aims to evaluate the effectiveness of a novel telemedicine-enabled integrated care model led by rural doctors in reducing cardiovascular and cerebrovascular events among elderly adults…
- Conditions
- Stroke, Brain Ischemia, Cerebral Hemorrhage, Transient Ischemic Attack
- Trial name
- NCT07628283
- Testing
- Enhanced Usual Stroke Care, Digital Health Platform-Supported Integrated Stroke Management
- Where
- 2 sites in China
- Volunteers
- 2,510 people
- Sponsor
- Jiangsu Province (Suqian) Hospital
Hepatocellular Carcinoma (HCC)
A Study to Compare the Efficacy, Safety, Immunogenicity, and Pharmacokinetic Profile of HLX13 with YERVOY As a First-Line Treatment for Patients with Unresectable Hepatocellular Carcinoma
This is a multicenter, randomized, double-blind, parallel-controlled integrated phase I/III clinical study to evaluate the efficacy, safety, PK, and immunogenicity of HLX13 and YERVOY® in patients with unresectable hepatocellular…
- Trial name
- NCT06841185
- Testing
- HLX13, US-sourced YERVOY®, EU-sourced YERVOY®
- Volunteers
- 656 people
- Sponsor
- Shanghai Henlius Biotech
Obesity & Overweight, Weight Loss
GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study
This research program includes two coordinated prospective studies (FLOURISH and THRIVE) evaluating the real-world effectiveness of Noom's digital health programs on weight, cardiometabolic biomarkers, physiological health…
- Conditions
- Obesity & Overweight, Weight Loss, Preventative Health, Body Weight
- Trial name
- FLOURISH (NCT07588984)
- Testing
- Noom Weight, Free Tier, Education-only control
- Where
- United States
- Volunteers
- 2,310 people
- Sponsor
- Noom Inc.
Chronic Pain, Post Traumatic Stress Disorder (PTSD)
Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD
The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs.
- Trial name
- NCT07116109
- Testing
- Transcranial Direct Current Stimulation (tDCS), Massed-Prolonged Exposure (PE)
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- The University of Texas Health Science Center, Houston
Primary CNS Lymphoma, Brain Lymphoma
Prospective Neurobehavioral Functions in Newly-diagnosed Patients With Primary CNS Lymphoma Treated With Hyperfractionated Conformal Whole-brain Radiation Therapy Plus Simultaneous Integrated Boost
Primary central nervous system lymphoma (PCNSL) is an uncommon disease. Conventional treatment has consisted of either whole-brain radiation therapy (WBRT) or methotrexate (MTX)-based combined modality therapy integrating…
- Trial name
- NCT04006561
- Testing
- A treatment protocol of combined chemoradiation delivered in the manner of hyperfractionated conformal whole-brain radiation therapy
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Temporomandibular Disorders (TMD), TMJ Disorder
Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders
This study aims to improve clinical efficiency and effectiveness in treating Temporomandibular Disorders (TMD). The researchers will integrate machine learning technology with clinical examination data, CBCT, and MRI to identify…
- Conditions
- Temporomandibular Disorders (TMD), TMJ Disorder, TMJ Pain
- Trial name
- NCT07771296
- Testing
- Low-Level Laser Acupuncture, Proprioceptive Training, Stabilization Splint Treatment
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- En Chu Kong Hospital
Mental Health, Cross-sectoral Treatment
Nationwide Uniform Scientific Evaluation of Flexible and Integrated Treatment Projects From 2022 Onwards
This study is an evaluation of flexible and integrated psychiatric care models (according to § 64b of the German Social Code Book V (SGB V)) (FIT) including new FIT projects starting after 2022 and the prolongation of any of 19…
- Conditions
- Mental Health, Cross-sectoral Treatment, Flexible and Integrated Treatment, FIT
- Trial name
- EVA64_2 (NCT05855720)
- Testing
- FIT model project
- Where
- Germany
- Volunteers
- 30,000 people
- Sponsor
- Technische Universität Dresden
Cerebral Palsy, Cerebral Palsy (CP)
Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT/OT Caregiver "Primer" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy
This study focuses on the caregiver's knowledge, comfort, and confidence in interacting with and supporting their infant with Cerebral Palsy (CP) or at high risk for Cerebral Palsy.
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Infantile, Infant
- Trial name
- CIRCLE-CP (NCT07469514)
- Testing
- Caregiver knowledge, Physical therapy, Occupational Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Prostate Cancer, Sleep Disturbance
eMindExCare for Prostate Cancer Patients Undergoing Active Treatment
This feasibility randomized controlled trial will assess the acceptability, feasibility, and preliminary effects of an integrated mindfulness and exercise eHealth intervention, eMindExCare, among prostate cancer patients…
- Conditions
- Prostate Cancer, Sleep Disturbance, Fatigue, Physical Inactivity
- Trial name
- eMindExCare (NCT07735273)
- Testing
- eMindExCare, Enhanced Health Education
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton