Clinical trials: Insulin Sensitivity
Type 2 Diabetes
Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02443922
- Testing
- Glimepiride, Sitagliptin, Metformin
- Volunteers
- 100 people
- Sponsor
- Foundation for the National Institutes of Health
Metabolic Syndrome, Insulin Sensitivity
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
The purpose of this study is to look at how insulin (a hormone that helps the cells get energy from sugar) in our body affects blood vessels (elasticity in the bigger blood vessels and blood flow in the smaller blood vessels in…
- Trial name
- EJB044 (NCT02633488)
- Testing
- metformin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Virginia
Obesity, Insulin Resistance
Race, Menopause and Metabolism After Exercise and Diet
The purpose of this study is to test the hypotheses that there are ethnic and genetic differences in the mechanisms and magnitude by which hypocaloric weight loss and aerobic exercise affect body composition, glucose, lipid…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- NCT00882141
- Testing
- Diet modification, Aerobic exercise
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Diabetes Mellitus, Type 2
Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes
This study will look at how CagriSema, semaglutide and cagrilintide regulate insulin effects in the body of people with type 2 diabetes (T2D).
- Trial name
- NCT06403761
- Testing
- Semaglutide, Cagrilintide
- Where
- Germany
- Volunteers
- 158 people
- Sponsor
- Novo Nordisk A/S
Prostate Cancer
The Effect of Endurance Training on Body Composition and Insulin Sensitivity in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
The purpose of the present study is to investigate if endurance training can be used as a therapeutic action against the adverse metabolic disturbances and unfavourable changes in body composition that accompany the androgen…
- Trial name
- NCT01676480
- Testing
- Endurance training
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inge Holm
Insulin Resistance
Effect of Polyphenol-rich Dark Chocolate on Insulin Sensitivity in Normal Weight and Overweight Adults
The purpose of the study is to determine the effect of polyphenol-rich dark chocolate on insulin sensitivity in normal weight and overweight adults.
- Trial name
- NCT01749020
- Testing
- Polyphenol-rich Dark chocolate
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Insulin Sensitivity, Type 2 Diabetes
Exercise and Diet in Type 2 Diabetic Women
The purpose of this study was to evaluate the effects of 12 weeks' increased daily physical activity versus diet restriction on regional fat distribution, insulin sensitivity and adipokines including retinol binding protein-4…
- Trial name
- NCT00763074
- Testing
- Standard life style modification for type 2 diabetes, Diet restriction, Exercise
- Volunteers
- 70 people
- Sponsor
- Eulji University Hospital
Insulin Resistance, Obesity
Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men
A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness.
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome
- Trial name
- NCT01962857
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Insulin Sensitivity, Aging
Implication of Metabolic and Genomic Modifications in Elderly Subjects
An increase of longevity and of the number of men and women older than 60 years old is observed in most industrialized countries.
- Trial name
- COMPALICLAMP (NCT00951392)
- Testing
- euglycemic hyperinsulinemic clamp, muscle biopsy, indirect calorimetry
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Major Depressive Disorder (MDD)
tVNS, Motivation, and Insulin Sensitivity
Disturbances in energy metabolism significantly increase the risk of developing major depressive disorder (MDD), especially in individuals with type 2 diabetes.
- Trial name
- NCT07198100
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Oral glucose tolerance test (oGTT)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Pre-diabetes, Insulin Sensitivity
Understanding Dose Related Effects of Strawberry
The proposed research is designed to extend previous research findings building on the knowledge of strawberries as fruits that support a healthy immune and vascular system.
- Conditions
- Pre-diabetes, Insulin Sensitivity, Insulin Resistance, Inflammation
- Trial name
- STRW (NCT06173765)
- Testing
- freeze-dried whole strawberry powder 36 g powder, freeze-dried whole strawberry powder 12 g, freeze-dried control powder 0 g strawberry
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Type 2 Diabetes, Inflammation
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
Every 3 minutes a new case of diabetes is diagnosed in Canada, mostly type 2 diabetes (T2D) increasing the risk for heart disease.
- Conditions
- Type 2 Diabetes, Inflammation, Insulin Sensitivity/Resistance, Fatty Acids, Omega-3
- Trial name
- NCT04485871
- Testing
- Omega-3 fatty acids
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Cliniques de Montreal
Obstructive Sleep Apnea, Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism
Obstructive sleep apnea affects approximately 2-4% of middle-aged adults in the general population and is associated with several medical conditions including hypertension and coronary artery.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Sleep-disordered Breathing
- Trial name
- SOMNOS (NCT01503164)
- Testing
- Positive Pressure Therapy (PAP), LifeStyle Counseling
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Insulin Resistance
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity
High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance.
- Trial name
- NCT05017675
- Testing
- High fructose diet, High saturated fat diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gestational Diabetes Mellitus
Study of Pregnancy Regulation of Insulin and Glucose
It is unknown whether beta cell dysfunction and insulin resistance in Gestational Diabetes Mellitus (GDM) is representative of a chronic maternal defect, unmasked by pregnancy, or whether it is the result of an imbalance of a…
- Trial name
- SPRING (NCT02763267)
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Massachusetts General Hospital
Metabolic Syndrome
Effect of Celery Seed on the Components of Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
The Metabolic Syndrome (MS) is a cluster of cardiometabolic risk factors, which include abdominal obesity, hyperglycemia, dyslipidemia, and high blood pressure.
- Trial name
- NCT06061926
- Testing
- Celery Seed
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- University of Guadalajara
Type 2 Diabetes Mellitus
Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes
The purpose of this study is to determine in type 2 diabetic patients in secondary failure to combined oral therapy whether, besides improvement in glycemic control, addition of exenatide, a new drug introduced to treat diabetes…
- Trial name
- NCT00948168
- Testing
- exenatide (Byetta)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance
Incretin mimetics are widely used pharmacological treatments for weight loss, known for their high efficacy and favorable safety profile.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Insulin Sensitivity/Resistance, Semaglutide
- Trial name
- TRIM-IR (NCT06856291)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- ETH Zurich
Type 2 Diabetes Mellitus
Effect of Eating Within a Limited Time on Sugar Sensitivity and Liver Sugar Stores of People With Type 2 Diabetes.
Modern life is characterized by a 24-hour lifestyle in which food intake is no longer restricted to daytime. As a result, people nowadays tend to eat throughout the day.
- Trial name
- TRF (NCT03992248)
- Testing
- Time restricted feeding, Control
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Maastricht University
Type 2 Diabetes Mellitus, Insulin Sensitivity/Resistance
The Effect of Exercise on Gut Microbiota in Type 2 Diabetic Patients
To investigate whether targeted lifestyle intervention (exercise), induces a change in intestinal fecal microbiota related to improved glycemic control and systemic inflammation in patients with DM type 2.
- Trial name
- NCT03380338
- Testing
- Combined aerobic and strength exercise
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Amsterdam UMC, location VUmc