Clinical trials: Insulin Sensitivity
Impaired Glucose Tolerance, Hyperinsulinism
Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes
This study investigated any potential associations between two isocaloric diets with different meal frequency (3 meals versus 6 meals) and glycemic control in people at high diabetes risk (lean and overweight/obese women with…
- Conditions
- Impaired Glucose Tolerance, Hyperinsulinism, Poor Glycemic Control, Hyperglycemia
- Trial name
- NCT02248272
- Testing
- Isocaloric diet with 3 meals, Isocaloric diet with 6 meals
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Meropi Kontogianni
Insulin Sensitivity
Vaspin Levels Compared With Serum Insulin and Blood Glucose Levels in Neonates
The aim of this study was to investigate circulating concentrations of vaspin in fetal and neonatal samples from SGA, AGA and LGA with the respective insulin concentrations.
- Trial name
- NCT01363622
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Obesity, Inflammation
Long-term Investigation of Resveratrol in Obesity
The aim of this study is to investigate potential metabolic effects of resveratrol in men with metabolic syndrome(otherwise healthy).
- Conditions
- Obesity, Inflammation, Insulin Sensitivity, Osteoporosis
- Trial name
- LIRMOI (NCT01412645)
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Glucose Intolerance
Acetylcarnitine and Metabolic Flexibility
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02072759
- Testing
- Carnitine supplement
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, Obesity
Genistein Stimulates Insulin Sensitivity Through Gut Microbiota
There is evidence that genistein present in soy can improve insulin resistance in rodents and humans with metabolic syndrome (MetS). However, it is not known if this improvement is associated with changes in the gut microbiota.
- Trial name
- GENISTEIN (NCT04105023)
- Testing
- genistein
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Metabolic Health, Insulin Sensitivity/Resistance
Defining the Human Insulin Resistance Molecular Network; SIGNATURE
The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it.
- Trial name
- SIGNATURE (NCT07255807)
- Testing
- Physical Inactivity, Hypercaloric High-Fat Diet
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity, Insulin Resistance
Understanding the Relationship Between Inflammation and Insulin Resistance in the Adipose Tissue
This study is being done to better understand the relationship between inflammation and insulin resistance in your Adipose (fat) Tissue .
- Trial name
- NCT02378077
- Testing
- Fat biopsy during scheduled abdominal surgery, Fat Aspiration, Fish Oil Supplement
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Resistance Training
Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity
To uncover the underlying mechanisms of resistance exercise training benefits on glucose metabolism and insulin sensitivity in muscle.
- Trial name
- NCT07128368
- Testing
- Resistance Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Insulin Resistance
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
The purpose of this study is to determine the effects of a dietary fiber, resistant starch, on insulin sensitivity. Low insulin sensitivity is a risk factor for some diseases including type 2 diabetes and heart disease.
- Trial name
- NCT01058135
- Testing
- Hi-maize starch (Low dose), Hi-maize starch (High-dose), Control (starch)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
HIV, Insulin Sensitivity
Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana
The purpose of this study is to assess the early longitudinal metabolic effects including insulin sensitivity in HIV-exposed uninfected (HEU) children compared to HIV-unexposed uninfected (HUU) children; as well as to determine…
- Conditions
- HIV, Insulin Sensitivity, Diabetes Mellitus
- Trial name
- NCT03088410
- Testing
- Zidovudine, Nevirapine
- Where
- Botswana
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Sleep, Body Composition
Nutrition, Body Composition, and Sleep
The purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.
- Conditions
- Sleep, Body Composition, Strength, Insulin Sensitivity
- Trial name
- SHAPE (NCT03603041)
- Testing
- Whey protein, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Healthy
Substrate Metabolism, Growth Hormone Signaling, and Insulin Sensitivity During Fasting
Background: Calorie restriction increases longevity in many species and attenuate the development of chronic disorders including type 2 diabetes, cardiovascular diseases and cancer.
- Trial name
- NCT02500095
- Testing
- Fasting, Saline, Pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency
Fatty Acid Oxidation Defects and Insulin Sensitivity
The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the…
- Conditions
- Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency, Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency, Medium-chain Acyl-CoA Dehydrogenase Deficiency
- Trial name
- NCT02517307
- Testing
- Intralipid/Heparin, Glycerol/Saline, Hyperinsulinemic euglycemic clamp
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Metabolic Syndrome, Obesity
Three Lifestyle Interventions on Endothelial Function and Cardiometabolic Risk in Obese Patients With Metabolic Syndrome
Obese patients with metabolic syndrome without diabetes or ischemic heart disease were randomized to three lifestyle interventions: 1. hypocaloric tailored diet with standard recommendations 2.
- Trial name
- NCT00943865
- Testing
- hypocaloric diet, Exercise recommendations, Pragmatic diet
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity and Type 2 Diabetes
Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in Youth
The overall goal of this project is to examine the physiological and metabolic effects of a 16-week circuit-training (strength training + aerobic activities) program, with and without a behavioral component utilizing motivational…
- Trial name
- NCT00693511
- Testing
- Circuit Training, Circuit training + motivational interviewing
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Infant, Small for Gestational Age
Safety Study In Patients Who Were Born Small And Short And Were Treated With Growth Hormone To Achieve Normal Height
The purpose of this study is to demonstrate that insulin sensitivity is not different between growth hormone - treated subjects who are small for gestational age (SGA) and an SGA cohort of subjects matched by gender and body mass…
- Trial name
- NCT00396474
- Testing
- post GH treatment observational study
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Polyphenolic Compounds and Metabolism
Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.
The proposed study aims to investigate that consumption of grape seed extract (GSE) would improve antioxidant status and impaired insulin action following consumption of a pro-oxidative high carbohydrate, high fat (HCHF) meal in…
- Trial name
- GSE2 (NCT01995643)
- Testing
- Active Capsule
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Insulin Sensitivity, Insulin Resistance
Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans
Participants will be randomly allocated to either Yakult ingestion or a control group. For the first 20 days, subjects will consume their normal diet (keeping a detailed food diary throughout).
- Conditions
- Insulin Sensitivity, Insulin Resistance, Type 2 Diabetes Mellitus
- Trial name
- NCT03037918
- Testing
- Yakult light
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Insulin Resistance, Transcranial Direct Current Stimulation
Improving Insulin Sensitivity by Non-invasive Brain Stimulation
Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease.
- Conditions
- Insulin Resistance, Transcranial Direct Current Stimulation, Obesity, Diabetes
- Trial name
- NCT04420650
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen