Clinical trials: Insulin Sensitivity
Insulin Sensitivity/Resistance
Aerobic Versus Resistance Exercises on Insulin Sensitivity in Obese Patients
The purpose of study is to compare the effect of different exercise modes on insulin resistance and body composition in obese patients.
- Trial name
- NCT06772857
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adiposity, Insulin Sensitivity
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners…
- Conditions
- Adiposity, Insulin Sensitivity, Weight Gain, Blood Pressure
- Trial name
- NCT05992688
- Testing
- Sucrose sweetened beverage, Stevia sweetened beverages, Calorie free flavored water beverage
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Insulin Sensitivity, Overweight or Obesity
Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
Objective 1: Characterize indices of systemic inflammation and gut microbiota composition and function after chronic (12 weeks) intake of pulses compared to control diet in human OW/OB-IR participants.
- Conditions
- Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
- Trial name
- PS (NCT04267705)
- Testing
- Control, Black bean, Chickpea
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Pre-diabetes, Insulin Sensitivity
Understanding Dose Related Effects of Strawberry
The proposed research is designed to extend previous research findings building on the knowledge of strawberries as fruits that support a healthy immune and vascular system.
- Conditions
- Pre-diabetes, Insulin Sensitivity, Insulin Resistance, Inflammation
- Trial name
- STRW (NCT06173765)
- Testing
- freeze-dried whole strawberry powder 36 g powder, freeze-dried whole strawberry powder 12 g, freeze-dried control powder 0 g strawberry
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
To Determine Whether Estrogen Influences the Effects of Training on Glycemic Control and Insulin Sensitivity
Does Estrogen Blunt the Effects of Exercise Training on Glycemic Control
Previous research has found that males and females respond differently to exercise training, particularly with respect to improvements in blood sugar control and immune system health.
- Trial name
- NCT07791394
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Adiposity, Insulin Sensitivity/Resistance
The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making
Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors.
- Conditions
- Adiposity, Insulin Sensitivity/Resistance, Decision-Making, Reward Learning
- Trial name
- No acronym (NCT07638059)
- Testing
- Beverage: Conditioned Stimulus -, Beverage: Conditioned Stimulus +
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Metabolic Health, Insulin Sensitivity/Resistance
Defining the Human Insulin Resistance Molecular Network; SIGNATURE
The goal of this intervention study is to learn more about what causes insulin resistance in otherwise healthy adults, and how short-term changes in physical activity or diet may influence it.
- Trial name
- SIGNATURE (NCT07255807)
- Testing
- Physical Inactivity, Hypercaloric High-Fat Diet
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Insulin Sensitivity, Glucose Intolerance
Effect of Dairy Products on Insulin Resistance
The objective of the study is to determine the effect of dairy consumption on insulin sensitivity in overweight and obese adults with prediabetes. Men and women (30-65 y) will be recruited from the greater Montreal area.
- Conditions
- Insulin Sensitivity, Glucose Intolerance, PreDiabetes
- Trial name
- NCT05421390
- Testing
- Reduced fat dairy, Regular fat dairy
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Lifestyle Factors, Overweight and Obesity
Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity.
- Conditions
- Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit
- Trial name
- NCT06180837
- Testing
- Sleep Extension Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
Resilience, Cognitive Function and Well-Being
Aging Resilience Through Microbiota Optimization and Regulation
Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration.
- Conditions
- Resilience, Cognitive Function and Well-Being, Muscle Function, Handgrip Strength Test, Insulin Sensitivity
- Trial name
- ARMOR (NCT06649981)
- Testing
- FMT capsule
- Where
- 2 sites in Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonzalo Jorquera, PhD
Diabetes Mellitus, Cardiovascular Diseases
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood.
- Conditions
- Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease
- Trial name
- NCT04055428
- Testing
- Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Sensitivity, Healthy Adult
Diaplex and Glycemic Control
The goal of this 16-week double-blind, placebo-controlled pilot study is to determine whether daily Diaplex supplementation improves insulin sensitivity and glycemic control in adults with elevated blood glucose levels, while…
- Trial name
- NCT07711587
- Testing
- Diaplex
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Insulin Resistance, Insulin Sensitivity
Fructose: Substrate, Stimulus, or Both?
This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Pre Diabetes
- Trial name
- NCT04168372
- Testing
- High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Insulin Sensitivity/Resistance
Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity
This study investigates whether: (i) a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity. (ii) being prediabetic affects exercise induced improvements in glycemic control.
- Trial name
- HIT (NCT02745613)
- Testing
- 8 weeks of combined exercise intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Aging, Insulin Sensitivity
Antecedent Metabolic Health and Metformin Aging Study
Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan.
- Conditions
- Aging, Insulin Sensitivity, Chronic Disease, Mitochondria
- Trial name
- ANTHEM (NCT04264897)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Insulin Sensitivity, Glucose Metabolism Disorders (Including Diabetes Mellitus)
Acute Microbial Switch
In this project the investigators will test if it is possible to measure changes in intestinal gas production after supplementation of a complex fiber mixture over a 36 hour period in both lean normoglycemic individuals and…
- Conditions
- Insulin Sensitivity, Glucose Metabolism Disorders (Including Diabetes Mellitus), Hyperinsulinism
- Trial name
- NCT05764200
- Testing
- Two day supplementation of a complex fiber mixture
- Where
- 2 sites in Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center