Clinical trials: Insulin Dependent Diabetes
Type 1 Diabetes
Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 Diabetes
The purpose of this study is to determine the effects of sitagliptin on glucose variability both after meals and overnight in adult patients with type 1 diabetes.
- Trial name
- NCT00978796
- Testing
- Sitagliptin, Sugar Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes, Type 2 Diabetes
Feasibility Trial of the Bios Device for Continuous Glucose Monitoring
The study is an open-label, prospective, within-subject comparison of the Bios device readings versus venous blood sample glucose readings, glucose readings from a Dexcom CGM and an SMBG device in subjects previously diagnosed…
- Trial name
- NCT04226846
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- GraphWear Technologies Inc.
Diabetes Mellitus, Type 1
The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM
The investigators intends to carry out a randomized, cross-over, prospective study which will last 48 weeks in youth with T1DM followed up by the center.
- Trial name
- NCT02765347
- Testing
- Metformin, Insulin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes
Dose Finding Study of Il-2 at Ultra-low Dose in Children With Recently Diagnosed Type 1 Diabetes
Human recombinant interleukin-2 (rhIL-2) is a biological signalling protein playing a key role in the regulation of the immune system.
- Trial name
- DFIL2-Child (NCT01862120)
- Testing
- Dose D1 of interleukin-2, Dose D2 of Interleukin-2, Dose D3 of interleukin-2
- Where
- 6 sites in France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus
Preschool CGM Use and Glucose Variability in Type 1 Diabetes
The objectives of this clinical study is to evaluate the efficacy continuous glucose monitoring (CGM) use on glucose variability (GV) in preschool children with T1D treated with CSII.
- Trial name
- NCT03293082
- Testing
- CGM ON, CGM OFF
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Type 1 Diabetes Mellitus
Comparing the Metabolic Control of Once to Twice-daily Insulin Detemir Injections
An open-label, treat to target, intervention study in order to compare the metabolic control of once to twice-daily insulin Detemir injections in children and adolescence with type 1 diabetes mellitus.
- Trial name
- NCT00542399
- Testing
- Levemir (insulin detemir), Levemir twice a day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
A Study to Compare ORMD-0801 Once Daily to ORMD-0801 Three Times Daily in Subjects With Type 1 Diabetes
This study is a Phase 2 randomized, crossover study comparing ORMD-0801 given QD versus TID in subjects with T1D. Subjects with T1D will have a screening visit (Visit 1) during which they will be required to review and sign the…
- Trial name
- NCT04150107
- Testing
- ORMD-0801 Treatment A, ORMD-0801 Treatment B
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oramed, Ltd.
Type 1 Diabetes
Effect of Fiber Supplementation in Children With Type 1 Diabetes
High fiber foods are recommended as a preferential source of carbohydrate by the Nutrition Study Group of the European Association for the Study of Diabetes.
- Trial name
- NCT01399892
- Testing
- soluble fiber in the form of benefiber
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes
Family Routines Enhancing Adolescent Diabetes by Optimizing Management
A three month randomized study to examine the potential benefits of sleep extension in tandem with clinical trial on diabetes management in youth with type 1 diabetes.
- Trial name
- FREADOM (NCT02974309)
- Testing
- Sleep Extension, Routine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Arizona
Hypoglycemia, Type1diabetes
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT05973799
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Type 1 Diabetes Mellitus With Hypoglycemia, type1diabetes
Intermediate and Long Acting Insulin Young Children Type 1 Diabetes.
Background: Achieving glycemic control without risking hypoglycemia imposes a major challenge in the management of toddlers and preschool children with Type 1 diabetes(T1D).
- Trial name
- NCT04664764
- Testing
- Degludec, Glargine, NPH insulin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Biomedical Technology, Type 1 Diabetes
Analysis of Glycemic Control in Type 1 Diabetes Patients Using Hybrid Closed Loop Insulin Pump Therapy (Medtronic 670G)
Observational study of patients at Boston Childrens Hospital with type 1 diabetes (T1D) who elected to treat their diabetes with the Medtronic 670 G hybrid closed loop insulin pump.
- Trial name
- NCT04051632
- Testing
- Medtronic 670G insulin pump
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes
The Role of Amylin and Glucagon in T1DM
The purpose of this study is to see if giving pramlintide and insulin before a meal would lower high blood sugar and if a glucagon (a naturally made hormone in the body but reduced in diabetes and its role is in prevention of low…
- Trial name
- NCT00206258
- Testing
- Pramlintide and glucagon
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Patient Care, Drug Therapy
Comparison of Two Management Systems in Patients With Type 1 Diabetes (Pediatric SmartHome)
Closed loop technology has been shown to reduce both hypoglycemia and hyperglycemia, as well as reduce glycemic variability. Sensor augmented pump (SAP) therapy means the addition of alerts according to high or low glucose values…
- Trial name
- NCT03815487
- Testing
- Medtronic MiniMed 670G Insulin Pump in Auto Mode, Medtronic MiniMed 670G Insulin Pump without Auto Mode
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Thyroid Function in DM
Thyroid Function Among Pediatric Patients With DM
Thyroid function among pediatric patients with type1 diabetes mellitus at the first presentation, from patients' characteristics to disease severity
- Trial name
- NCT05717933
- Testing
- thyroid hormones
- Volunteers
- 70 people
- Sponsor
- Assiut University
Type I Diabetes
Anti-IL-1 Treatment in Children Diabetic Keto-Acidosis (DKA) at Diagnosis of Type 1 Diabetes
This is a randomized, double-blind, placebo-controlled phase 2 study. Specific aim is to evaluate feasibility and safety of anti-IL-1 (interleukin 1) treatment in the course of standard therapy for diabetic ketoacidosis in…
- Trial name
- NCT01477476
- Testing
- Anakinra
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this clinical trial is to evaluate the variability in the blood glucose-lowering effect of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- NCT00961324
- Testing
- insulin degludec, insulin glargine
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Guided Self-determination - Promoting Self-management in Type 1 Diabetes
Background: 50% of people with diabetes are living with too high blood sugars and increased risk of diabetes related complications together with poor quality of life.
- Trial name
- GSD (NCT01317459)
- Testing
- Guided self-determination
- Where
- Norway
- Volunteers
- 216 people
- Sponsor
- Haukeland University Hospital
Type 1 Diabetes, Blood Glucose, Low
The Effect of Rapid and Slow Glucose Fall on the Subsequent Glucose Production in People With Type 1 Diabetes
In the effort of better understanding the glucose control in people with type 1 diabetes, in-depth insight into the physiology of hepatic glucose production and its influencing factors is essential.
- Conditions
- Type 1 Diabetes, Blood Glucose, Low, Glucose Metabolism Disorders
- Trial name
- RaSlo-19 (NCT04098549)
- Testing
- Rapid lowering of plasma glucose, Slow lowering of plasma glucose
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Steno Diabetes Center Copenhagen
Patients With Type 1 Diabetes
Allogeneic Islet Transplantation for the Treatment of Type 1 Diabetes
It is a multicentre, sequential, phase II clinical trial, aiming at evaluating the allogeneic islet transplantation for the treatment of type 1 diabetes.
- Trial name
- GRIIF (NCT01974674)
- Testing
- Allogeneic transplantation of intrahepatic islet
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris