Clinical trials: Injection Site
Hypercholesterolemia
Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects
Primary Objective: To assess the relative bioavailability of a single subcutaneous dose of alirocumab SAR236553 (REGN727) administered at 3 different injection sites in healthy subjects.
- Trial name
- NCT01785329
- Testing
- alirocumab SAR236553 (REGN727)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanofi
Intracutaneous Drug Delivery
Site Selection for Intracutaneous Saline Delivery
The goal of this exploratory study is to select the optimal body site for intracutaneous delivery of 0.5 milliliters of saline from the FLUGEN 101.2 microneedle-based device.
- Trial name
- NCT01767324
- Testing
- Injection to deltoid, Injection to forearm, Injection to thigh
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- FluGen Inc
Metastatic Breast Cancer, Metastatic Gastric Cancer
Clinical Study to Compare the Pharmacokinetics and Safety of Trastuzumab for Injection With Herceptin® in Healthy Male Volunteers
Trastuzumab for injection is a biosimilar of Herceptin ® produced by Chia Tai Tianqing Biotechnology Co., LTD, which is a humanized IgG1 monoclonal antibody produced by chinese hamster ovary (CHO) cells.
- Trial name
- NCT05765357
- Testing
- Trastuzumab for injection, Herceptin
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Type 2 Diabetes
A Clinical Study to Compare the Bioavailability of HR17031 in Healthy Subjects at Different Sites
The purpose of this study is to evaluate the bioavailability and safety of HR17031 injection in healthy subjects at different sites.
- Trial name
- NCT06086912
- Testing
- HR17031
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Tetanus, Acellular Pertussis
Evaluation of the Immunogenicity, Safety and Reactogenicity of the Combined DTPa-IPV Vaccine in Healthy Infants
DTPa and IPV vaccines are recommended for immunization of infants in Korea. The use of combination vaccines simplifies routine paediatric vaccination.
- Conditions
- Tetanus, Acellular Pertussis, Diphtheria
- Trial name
- NCT00290342
- Testing
- DTPa-IPV, DTPa, IMOVAX Polio®
- Where
- 9 sites in South Korea
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colonic Polyps, Colon Cancer
L-Menthol Injection as a Novel Technique During Colonoscopy
The primary objective of this double-blinded, prospective, randomized placebo-controlled study is to evaluate for change in endoscopic adenoma detection rates (ADR) with the use of peppermint oil solution vs placebo application…
- Trial name
- MINT-C (NCT02588248)
- Testing
- Peppermint Oil
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Intramuscular Injection Pain
Effect of Traction-Pressure-Release and Manual Pressure on Intramuscular Injection Pain
The goal of this clinical trial is to evaluate whether two different intramuscular (IM) injection techniques-Manual Pressure and Traction-Pressure-Release (TPR)-can effectively reduce injection-related pain and improve patient…
- Trial name
- IM-PainTech (NCT07262463)
- Testing
- Standard Intramuscular Injection, Manual Pressure Technique, Traction-Pressure-Release (TPR) Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Melek Sahin
Healthy Participants
Comparative PK/PD of Single-Dose THDB0206 at Different Injection Sites
This open-label, randomized, three-period crossover, 8-hour hyperinsulinemic-euglycemic clamp study will compare the pharmacokinetic and pharmacodynamic profiles of THDB0206 after single subcutaneous administration at different…
- Trial name
- NCT07257627
- Testing
- THDB0206 injection-Upper arm, THDB0206 Injection-Abdomen, THDB0206 Injection-Thigh
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tonghua Dongbao Pharmaceutical Co.,Ltd
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Infertility
The Pharmacokinetic and Bioavailability of GenSci094 Before and After a Change in Manufacturing Site
The bioavailability study is intended to evaluate the pharmacokinetic (PK) characteristics and the bioavailability of the two formulations in humans before and after the change of production site, in order to assess the possible…
- Trial name
- NCT06095206
- Testing
- GenSci094
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Postoperative Pain
Feasibility Study on Pain Control After Laparoscopic Cholecystectomy
The objective of the study is to hopefully understand the most beneficial way to control pain after removing the gallbladder by keyhole surgery (laparoscopic cholecystectomy).
- Trial name
- NCT03532906
- Testing
- TAP Block, Control
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Injection Site Irritation
Assessment of Pain on Propofol Injection.
Title: Assessment of pain on lidocaine-Propofol admixture injection: Comparing large antecubital vein and small vein dorsum of hand.
- Trial name
- NCT04673500
- Testing
- Propofol lidocaine through large vein, Propofol lidocaine through small vein
- Where
- Saudi Arabia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University Hospital
Pain, Postoperative
Optimal Injection Site for Serratus Anterior Plane Block in Reconstructive Breast Surgery
The novel introduction of various chest wall blocks such as the Pecs I and II/modified Pecs blocks as well as the Serratus Anterior Plane Block have extended the application of perioperative regional anesthesia to provide…
- Trial name
- NCT03183596
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Participants
A Study of Two Formulations (Both Refrigerated and Room Temperature) Using an Autoinjector Device in Healthy Participants
The main purpose of the study is to assess the injection site pain intensity of two formulations using prefilled autoinjector device in healthy participants.
- Trial name
- NCT05154968
- Testing
- Sodium chloride, Citrate buffer, Mannitol
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Gingival Overgrowth, Gingival Hyperplasia
Effect of Injectable Platelet-rich Fibrin (i-PRF) on Wound Healing After Gingivectomy
This study evaluates the clinical and biochemical effects of injectable platelet-rich fibrin (i-PRF) on wound healing after gingivectomy, a surgical procedure used to treat gingival overgrowth.
- Trial name
- i-PRF-GIN (NCT07785349)
- Testing
- injectable Platelet-Rich Fibrin (i-PRF), Conventional Gingivectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Şeyma Çardakçı
Healthy Volunteers
A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects
The main objective is to study how astegolimab may behave in the body when injected subcutaneously into the abdomen, thigh, or upper arm in healthy participants.
- Trial name
- NCT06462118
- Testing
- Astegolimab
- Where
- 3 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Carpal Tunnel Syndrome, De Quervains Tenosynovitis
The SToICAL Study - The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study
Some hand conditions can be treated with a steroid injection. Some doctors mix the steroid with local anaesthetic in the hope that the patient will experience less pain after the injection. Some doctors do not do this.
- Conditions
- Carpal Tunnel Syndrome, De Quervains Tenosynovitis, Trigger Finger
- Trial name
- SToICAL (NCT04253457)
- Testing
- 1ml of triamcinolone (40mg/1ml)
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Healthy
A Study of How the Body Absorbs LY3537031
The main purpose of this study is to find out how much LY3537031 gets into the blood stream and how long it takes the body to get rid of it when it is injected just under the skin in different parts of the body, and when it is…
- Trial name
- NCT07202871
- Testing
- LY3537031
- Where
- Singapore
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypercholesterolemia
Injection Site Tolerability, Safety, Pharmacokinetics, Pharmacodynamics in Different Single-Dose Treatments of Alirocumab SAR236553 (REGN727) in Healthy Subjects
Primary Objective: Injection Site Tolerability Secondary Objectives: To assess the safety profile of alirocumab SAR236553 (REGN727) To assess the pharmacokinetic-pharmacodynamic relationship of alirocumab SAR236553 (REGN727)
- Trial name
- NCT01443650
- Testing
- alirocumab SAR236553 (REGN727)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sanofi