Clinical trials: Influenza, Human, open to volunteers
Influenza
A Trial of RLX-2508-102 in Healthy Volunteers
The purpose of this study is to assess safety, PK and immunogenicity profile of a single dose and multiple dose of RLX-2508 in healthy participants across different ethnic backgrounds.
- Trial name
- NCT07873671
- Testing
- RLX-2508
- Where
- 3 sites in Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Atridia Pty Ltd.
Acute Coronary Syndrome, Heart Failure
Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)
The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Heart Failure, Influenza, Human, Cardiovascular Diseases
- Trial name
- VACC-UP (NCT07721649)
- Testing
- Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination
- Where
- 2 sites in Germany
- Volunteers
- 482 people
- Sponsor
- Stephan Baldus
Mucosal Immune Response to Influenza Vaccination
How Healthy Adults Respond to the Nasal Flu Vaccine
This study is looking at how the immune system in the nose responds after receiving the FluMist nasal flu vaccine in healthy adults. FluMist is an FDA-approved influenza vaccine that is given as a nasal spray.
- Trial name
- MOSAIC (NCT07726862)
- Testing
- FluMist (Live Attenuated Influenza Vaccine)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Seasonal Influenza
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Children
The purpose of this study is to evaluate safety, reactogenicity, and immunogenicity of mRNA-1010 in healthy children (9 to <18 years of age).
- Trial name
- NCT07870330
- Testing
- mRNA-1010, Fluarix Trivalent
- Where
- 6 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Influenza, COVID-19
Flu COVID Vaccine Views
This study addresses a critical evidence gap relevant to implementation strategies for combination vaccines in health care settings.
- Conditions
- Influenza, COVID-19, Vaccination Willingness
- Trial name
- NCT07871448
- Testing
- Survey
- Where
- 2 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- George Washington University
Respiratory Tract Infection, Smell Disorder
Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)
Background: Loss of the sense of smell can seriously affect a person's quality of life. The ability to smell can be damaged by many factors, including illnesses, injuries, and exposure to toxic chemicals.
- Conditions
- Respiratory Tract Infection, Smell Disorder, Influenza, Rhinosinusitis
- Trial name
- NCT07149428
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Influenza, Human
A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age
This clinical trial will study an investigational seasonal influenza vaccine in adults 18 to 64 years of age. The vaccine is based on messenger ribonucleic acid, also called mRNA.
- Trial name
- NCT07851246
- Testing
- mRNA Seasonal Flu vaccine, Comparator 1, Comparator 2
- Where
- 12 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19 Respiratory Infection, Influenza
Light-based Immunomodulation for Guarding Against Human Respiratory Tract Infections
The purpose of trial is to determine if daily usage of a photobiomodulation device will decrease the incidence of upper respiratory tract infections (URI) due to COVID, influenza or other viruses.The RD-X10 device is handheld…
- Trial name
- LIGHT (NCT07610967)
- Testing
- RD-X19
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- David Moss
Influenza Vaccination
Family Physician Nudges for Influenza Vaccination Among Older Adults
The goal of this clinical trial is to learn if a family-physician nudge intervention works to improve influenza vaccination among adults aged 55 years and older in China.
- Trial name
- NCT07864597
- Testing
- Family Physician Influenza Vaccination Nudge
- Volunteers
- 5,250 people, healthy volunteers welcome
- Sponsor
- Fudan University
Influenza -Like Illness, Influenza (Healthy Volunteers)
Mucosal and Systemic Immunity Correlates of Protection Against Influenza in Young Children, Aged 2-5 Years (MUSIC-Flu)
Title: Mucosal and systemic immunity correlates of protection against influenza in young children (MUSIC-Flu). The goal of this observational study is to better understand how immune responses in the blood and mucosa are linked…
- Trial name
- MUSIC-Flu (NCT07861854)
- Where
- South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute for Communicable Diseases, South Africa
Viral Lung Infection and Acute Respiratory Failure
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
- Trial name
- TILIA (NCT05624450)
- Testing
- Tozorakimab
- Where
- 471 sites in United States, Argentina and 37 more
- Volunteers
- 3,527 people
- Sponsor
- AstraZeneca
Nosocomial Infections
Nosocomial Respiratory Virus Infection
Hospital-acquired Viral Respiratory Infections (HAVRI) are associated with substantial burden on health care systems. The prevention and control of these viral infections rely on multiple measures such as hand hygiene or wearing…
- Trial name
- NOSOVIRUS (NCT06643039)
- Testing
- Nasopharyngeal swab, Questionnaire
- Where
- 6 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
COVID-19, SARS-CoV-2 Infection, RSV
Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)
The purpose of this study is to comprehensively describe the temporal and geographic utilization of COVID-19 therapies used for mild to moderate disease during different periods of SARS-CoV-2 variant circulation as well as to…
- Conditions
- COVID-19, SARS-CoV-2 Infection, RSV, Influenza
- Trial name
- COPE-VA (NCT06160128)
- Where
- United States
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Influenza, Influenza-like Illness
Abbott ID NOW Point-of-Care Testing
With the rapid aging of the global population, long-term care facilities (LTCFs) have become an increasingly important component of modern public health systems.
- Trial name
- IDNOW2026 (NCT07846423)
- Testing
- Abbott ID NOW Point-of-Care Testing, Standard Laboratory-Based RT-PCR Diagnostic Pathway
- Where
- Taiwan
- Volunteers
- 1,080 people
- Sponsor
- China Medical University Hospital
Immunization; Infection, Transplantation Infection
High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients
Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV).
- Conditions
- Immunization; Infection, Transplantation Infection, Influenza
- Trial name
- PSOT (NCT05947071)
- Testing
- Standard Dose Quadrivalent Inactivated Influenza Vaccine, High Dose Quadrivalent Inactivated Influenza Vaccine
- Where
- 10 sites in United States
- Volunteers
- 312 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza Vaccination, Older Adults (65 Years and Older)
Influenza Vaccine Immunogenicity in Repeatedly Vaccinated Older Adults
The goal of this clinical trial is to compare immune responses to different influenza vaccine formulations in older adults and to understand how immune aging and repeated annual influenza vaccination affect these responses.
- Conditions
- Influenza Vaccination, Older Adults (65 Years and Older), Immunosenescence, Immunogenicity
- Trial name
- NCT07838298
- Testing
- Standard dose influenza vaccine, MF59 adjuvanted influenza vaccine, High dose influenza vaccine
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Acute Respiratory Infections (ARIs), Influenza
Effect of Surgical Masks in Preventing Acute Respiratory Infections
The goal of this clinical trial is to evaluate the efficacy of surgical masks in preventing acute respiratory tract infections. The main question it aims to answer is: Does wearing a mask prevent you from getting acute…
- Conditions
- Acute Respiratory Infections (ARIs), Influenza, COVID - 19
- Trial name
- NCT07739446
- Testing
- Surgical masks
- Where
- Japan
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Chiba University
No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with…
- Trial name
- NCT07786467
- Testing
- Osteopathic Manipulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lake Erie College of Osteopathic Medicine
Zika, Influenza
Screening for LID Clinical Studies Unit Healthy Volunteer Protocols
Background: The Laboratory of Infectious Diseases (LID) Clinical Studies Unit (CSU) enrolls healthy volunteers into clinical studies to study infectious diseases. Viruses can be highly infectious and contagious.
- Trial name
- NCT01386424
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)