Clinical trials: Inflammatory Marker
Sepsis, Acute Kidney Injury Due to Sepsis
Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury
In our study, 17 septic, 43 sepsis-related acute kidney injury and 24 control patients were enrolled. Blood and urine samples were collected at the intensive care unit from acutely diagnosed septic and sepsis-related acute kidney…
- Trial name
- NCT04968262
- Testing
- Sepsis therapy, Sepsis-related acute kidney injury therapy
- Where
- Hungary
- Volunteers
- 84 people
- Sponsor
- University of Pecs
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Sepsis and Septic Shock
Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients
The condition of sepsis patients changes rapidly, whom are often accompanied by impaired respiratory, circulatory, renal, and coagulation functions. So far, the prognosis of sepsis at home and abroad is not ideal.
- Conditions
- Sepsis, Sepsis and Septic Shock, Infection
- Trial name
- sepsis model (NCT06904001)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis
Multi-marker INDex for the Risk Assessment of Sepsis in the Emergency departmenT (MINDSET)
The purpose of the study is to procure blood samples from patients ≥18 years of age who present to the Emergency Department (ED) with at least two of the diagnostic criteria for sepsis.
- Trial name
- MINDSET (NCT00472628)
- Testing
- Blood samples collected
- Where
- 24 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Pouchitis, Ulcerative Colitis
Assessment of Patients With Acute Pouchitis Treated With Antibiotics
The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy…
- Trial name
- NCT05252273
- Testing
- Observational, No intervention
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 43 people
- Sponsor
- Alimentiv Inc.
Late-Onset Neonatal Sepsis
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- EMERAUDE (NCT03299751)
- Testing
- Diagnostic performances of biomarkers combination
- Where
- 2 sites in France
- Volunteers
- 233 people
- Sponsor
- Hospices Civils de Lyon
Periodontal Diseases, Inflammatory Response
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers for the diagnosis and prognosis of diseases.
- Trial name
- NCT03510702
- Testing
- Levels of epigenetic biomarkers present in the gingival fluid and its possible relationship with bone metabolism.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Arrhythmogenic Cardiomyopathy
Diagnostic Contribution, Prognosis and Physiopathological Aspects in Arrhythmogenic Cardiomyopathy. (ACORE)
This study aims to identify novel inflammatory biomarkers in AC, whether in circulating blood, in situ or as imaging biomarkers to better understand the pathophysiology of the disease and then to determine contribution to the…
- Trial name
- ACORE (NCT05569356)
- Testing
- Prospective, Retrospective
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, Acute
Oral DLBS1033 as Adjunctive Therapy in Acute Ischemic Stroke: Impact on Inflammatory Biomarkers and Outcomes
This randomized, double-blind, placebo-controlled trial aims to evaluate the effect of oral DLBS1033 as adjunctive therapy on inflammatory biomarkers (IL-6, TNF-α, MMP-9, D-dimer), transcranial Doppler (TCD) parameters, and…
- Trial name
- NCT07121569
- Testing
- Oral lumbrokinase DLBS1033
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Sebelas Maret
Crohn's Disease
MOlecular BIomarkers and Adherent and Invasive Escherichia Coli (AIEC) Detection Study In Crohn's Disease Patients
The study is a multicenter, international descriptive study with a bio-collection in 300 evaluable Crohn's disease patients to be processed after usual biological tests via bioinformatics tools.
- Trial name
- MOBIDIC (NCT02882841)
- Testing
- Biopsies, stool and blood collection
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 143 people
- Sponsor
- Enterome
Thoracic Surgery
Effects of Permissive Hypercapnia During Lung Surgery on Inflammatory Biomarkers in Serum and Bronchoalveolar Lavage Fluid
The primary objective was to evaluate the effects of permissive hypercapnia on inflammatory biomarkers in bronchoalveolar lavage fluid and serum during one-lung ventilation.
- Trial name
- NCT07749456
- Testing
- Allowed permissive hypercapnia
- Volunteers
- 40 people
- Sponsor
- University of Nis
Sepsis, Septic Shock
Sepsis ICU Gut Microbiome Analysis
Sepsis is a life-threatening condition in which the body's response to an infection damages its own organs. This study aims to understand how the bacteria living in the gut change during sepsis and whether patterns of gut…
- Trial name
- SIGMA (NCT07864818)
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Periodontal Diseases, Periodontitis
The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.
Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process.
- Trial name
- NCT04404335
- Testing
- Crevicular fluid analysis by using ELISA testing.
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Depression
Inflammatory Biomarkers and Brain Metabolites, a Study Based on Magnetic Resonance Spectroscopy
Suicidal behaviors (SB) are a major health problem in France : 10 000 suicides and 220 000 suicide attempts every year. SB management is therefore a major public health issue.
- Trial name
- BICS (NCT03052855)
- Testing
- Magnetic Resonance Imaging (MRI) and biological samples
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
Inflammatory Biomarkers Predict Pulmonary Outcomes in Coronary Artery Bypass Grafting
The primary objective of this pilot study is to identify and quantify inflammatory and genetic markers from bronchoalveolar lavage fluid (BALF) and serum in patients with a history of chronic obstructive pulmonary disease (COPD)…
- Trial name
- CABG BALF (NCT01366469)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Cancer Survivors, Cardiotoxicity
In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors
The BREATHS trial aims to investigate whether overnight in-bedroom air filtration reduces inflammation and cardiac biomarkers in adult survivors of cancer who are at high risk for cardiovascular complications.
- Conditions
- Cancer Survivors, Cardiotoxicity, Cardiovascular Toxicity Induced by Antitumoral Drugs
- Trial name
- BREATHS (NCT06778122)
- Testing
- High efficiency particulate air filtration system (nightly administration), High efficiency particulate air filtration system (nightly and daily administration)
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University College, London
Traumatic Brain Injury
Evaluation the Effects of French Maritime Pine Bark Extract on the Clinical Status in Traumatic Brain Injury Patients
Introduction: Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. Immune-enhancing enteral formula has been proven to significantly reduce infection rate in TBI patient.
- Trial name
- NCT03777683
- Testing
- Dietary Supplement (OLIGOPIN)
- Where
- Iran
- Volunteers
- 67 people
- Sponsor
- Mashhad University of Medical Sciences
Sepsis
ACOD1 as a Prognostic Marker for Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with high morbidity and mortality worldwide. Reliable biomarkers are needed for early risk stratification and outcome prediction.
- Trial name
- NCT07533994
- Testing
- Blood draw for lab testing.
- Where
- 2 sites in China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Infections, Sepsis
A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children
A case-control cohort study to develop and validate the performance of a whole blood gene expression test to distinguish sepsis infection from uninfected systemic inflammatory response syndrome cases in symptomatic adults and…
- Conditions
- Infections, Sepsis, SIRS
- Trial name
- NCT05142813
- Testing
- Diagnostic Test: Blood specimen collection
- Volunteers
- 1,100 people
- Sponsor
- mProbe Inc.
Sepsis, Immune Deficiency
Presepsin as Detective Marker of Sepsis in Immunodeficiency ICU Patients
This is an observational study to evaluate the diagnostic and prognostic value of presepsin in the critically-ill immunocompromise patients.
- Trial name
- PREICU (NCT03881566)
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- Jongmin Lee