Clinical trials: Inflammatory Bowel Disease, open to volunteers
Ulcerative Colitis (Disorder), Inflammatory Bowel Disease (IBD)
Mediterranean Diet and Time-Restricted Feeding in Ulcerative Colitis Remission
This study will evaluate whether a 12-week dietary intervention can improve gut health, inflammation, and quality of life in adults with ulcerative colitis in remission.
- Trial name
- MEDITIME-UC (NCT07752446)
- Testing
- Mediterranean Diet, Mediterranean Diet + Time-Restricted Feeding, Standard Dietary Advice
- Where
- Chile
- Volunteers
- 45 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Inflammatory Bowel Disease 5
Diagnostic Performance of Controlling Nutritional Status as a Nutritional Screening Tool in Patients With Inflammatory Bowel Disease
The objective of this observational study is to determine the diagnostic performance of CONUT as a nutritional screening tool in patients with Inflammatory Bowel Disease.
- Trial name
- CONUT (NCT06648551)
- Testing
- CONUT
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexico
Ulcerative Colitis
Long-term Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis
Although the incidence of inflammatory bowel disease is stable in North American and European countries, the incidence of inflammatory bowel disease is increasing in newly industrialized countries, especially in China.
- Trial name
- NCT07114159
- Testing
- Sacral nerve stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Xijing Hospital
Crohn Disease
Fecal Microbiota Transplantation in Pediatric Crohn's Disease
This study will test the safety and effectiveness of fecal microbiota transplantation (FMT) plus partial enteral nutrition (PEN) in refractory pediatric Crohn's disease (CD) who have failed conventional treatment
- Trial name
- FMT (NCT05321745)
- Testing
- Standardized FMT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Biao Zou
Inflammatory Bowel Disease
A Clinical Study of SPH7854 Granules in Healthy Subjects.
To evaluate the safety of SPH7854 in healthy subjects.
- Trial name
- NCT06483373
- Testing
- SPH7854
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Ulcerative Colitis
Efficacy of Subcutaneous Infliximab in Acute Severe Ulcerative Colitis: a Multicenter Retrospective Study
Around 25% of patients with ulcerative colitis will develop acute severe colitis during the course of their disease. The first-line treatment for acute severe colitis is intravenous corticosteroid therapy.
- Trial name
- ISAC (NCT06998797)
- Testing
- Data collection
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis
Study Evaluating ISM5411 Administered Orally to Subjects With Active Ulcerative Colitis (BETHESDA)
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and clinical efficacy of ISM5411 in adult patients with active ulcerative colitis.
- Trial name
- NCT07265570
- Testing
- ISM5411 tablets
- Where
- 28 sites in China
- Volunteers
- 80 people
- Sponsor
- InSilico Medicine Hong Kong Limited
Crohn's Diseases, Crohn's Disease
A Phase 1 Study of ATORM-C in Patients With Crohn's Disease
This Phase 1 study evaluates the safety and tolerability of ATORM-C in patients with Crohn's disease. ATORM-C is an investigational product consisting of autologous adult stem cell-derived intestinal organoids.
- Trial name
- NCT07822087
- Testing
- Autologous Adult Stem Cell-Derived Intestinal Organoid
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- ORGANOIDSCIENCES LTD.
Inflammatory Bowel Diseases, Ulcerative Colitis
Evolution and Treatments of Chronic Inflammatory Systemic Diseases
Patients with chronic inflammatory diseases (CID) followed in gastroenterology, dermatology and rheumatology have physiopathological, epidemiological and therapeutic focal points.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease, Arthritis, Rheumatoid
- Trial name
- MISTIC (NCT04191395)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Crohn's Disease
Efficacy and Safety of Formulation Switching Between SC Infliximab and IV Infliximab in Patients With CD
The goal of this prospective, multicenter, open-label, randomized controlled, non-inferiority trial is to test efficacy and safety of formulation switching between subcutaneous (SC) infliximab and intravenous (IV) infliximab in…
- Trial name
- CHAMELEON (NCT06064864)
- Testing
- Infliximab-Dyyb
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Inflammatory Bowel Diseases, Pregnancy
Safety of IBD Drugs During Pregnancy and Breastfeeding: Mothers and Babies' Outcomes (DUMBO Registry)
This is a prospective, observational, multicenter registry, which will enrol pregnant women with IBD (CD, UC, or unclassified IBD) over 5 years in Spain.
- Trial name
- NCT03894228
- Where
- 73 sites in Spain
- Volunteers
- 1,750 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Crohn Disease (CD)
Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease
The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel.
- Trial name
- NCT06976853
- Testing
- Tirzepatide, Standard of care treatment
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Chronic Diarrhea, Persistent Vomitting
Pediatric GI Endoscopy at Assiut University
1. To evaluate the diagnostic role, and outcomes of upper and lower gastrointestinal (GI) endoscopy in identifying gastrointestinal disorders among infants and pediatric patients attending Assiut University Children Hospital. 2.
- Conditions
- Chronic Diarrhea, Persistent Vomitting, Gastrointestinal Bleeding, Dysphagia
- Trial name
- NCT07239934
- Testing
- Gastrointestinal Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases
Ex Vivo Study of hAMSC Secretome in Inflammatory Bowel Disease: Effects on Inflammation and Fibrosis (TARGET)
Inflammatory Bowel Diseases (IBD), including ulcerative colitis and Crohn's disease, are chronic immune-mediated disorders characterized by relapsing gastrointestinal inflammation driven by genetic, immune, microbial, and…
- Trial name
- TARGET (NCT07721207)
- Testing
- Human amniotic mesenchymal stromal cell (hAMSC)-derived secretome
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis
Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis
The primary objective of this study is to evaluate the efficacy (as measured by induction of remission) of two dose levels (low and high) per age group (5 to <12 and 12 to ≤17 years) of budesonide rectal foam as compared to an…
- Trial name
- NCT05976802
- Testing
- High dose budesonide rectal foam, Low dose budesonide rectal foam
- Volunteers
- 100 people
- Sponsor
- Bausch Health Americas, Inc.
Crohn's Disease Relapse, Inflammatory Bowel Diseases
Acupuncture Reduces Relapse in Patients With Crohn's Disease: a Superiority Trial
The aim of this study was to further improve the clinical efficacy of acupuncture in delaying the clinical recurrence of CD and to explore the efficacy mechanism of acupuncture efficacy enhancement.
- Trial name
- NCT06553053
- Testing
- "Harmonizing Shaoyang, nourishing spleen and kidney with warmth" Acupuncture Group, "Nourishing spleen and kidney with warmth" Acupuncture Group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Active Ulcerative Colitis
Superdonor FMT in Patients With Ulcerative Colitis
In the last decades fecal microbiota transplantation (FMT) has been established as a highly effective option in the treatment of recurrent Clostridioides difficile infection (rCDI), with a success rate of nearly 90%.
- Trial name
- NCT05739864
- Testing
- FMT
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis (UC)
Immunosuppressant Discontinuation in Elderly Patients With Ulcerative Colitis And Long-term Remission
IDEA is a Phase IV, prospective, randomised, open-label, multicentre clinical trial designed to evaluate the safety and efficacy of withdrawing thiopurines in elderly (≥60 years) patients with ulcerative colitis (UC) who are in…
- Trial name
- IDEA (NCT07248644)
- Testing
- Discontinuation of thiopurines.
- Volunteers
- 304 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Inflammatory Bowel Disease (IBD)
Benefit of Moderate Intensity Exercise in Patients With Clinical Quiescent Inflammatory Bowel Disease
The goal of this Randomised controlled trial is to investigate the effect of exercise on changes in quality of life in in patients with clinical quiescent Inflammatory bowel Disease.
- Trial name
- IBDEXERCISE (NCT07775794)
- Testing
- Exercise
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Crohn's Disease, Obesity or Overweight
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
The main purpose of this study is to evaluate the efficacy and safety of mirikizumab and placebo compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and…
- Trial name
- COMMIT-CD (NCT06937099)
- Testing
- Mirikizumab, Tirzepatide
- Where
- 183 sites in United States, Austria and 20 more
- Volunteers
- 290 people
- Sponsor
- Eli Lilly and Company