Clinical trials: Inflammatory Back Pain
Paraspinal Muscles, Low Back Pain
Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.
This multicenter, assessor-blinded, two-arm parallel randomized controlled trial (N = 314) will compare the efficacy and safety of a 6-week multidimensional exercise program plus usual pharmacological care (experimental arm)…
- Conditions
- Paraspinal Muscles, Low Back Pain, Machine Learning, Radiomics
- Trial name
- METNLBP (NCT07353372)
- Testing
- Multidimensional exercise intervention, Oral NSAIDs
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Xuanwu Hospital, Beijing
Low Back Pain
Radiographic and Inflammatory Biomarker Changes in Chronic Low Back Pain
OBJECTIVE: To find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects…
- Trial name
- NCT05253599
- Testing
- Isokinetic training, Virtual reality training, Exercises
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Prince Sattam Bin Abdulaziz University
Axial Spondyloarthritis, Inflammatory Back Pain
Reliability of IBP Criteria & Activity Scores in Patients With AxSpA
The current ASAS classification of AxSpA relies either on sacroiliitis on imaging plus one SpA feature (imaging arm) or HLA-B27 antigen plus two SpA features (clinical arm), in a patient with chronic back pain and age at onset of…
- Trial name
- IBP/AxSpA (NCT05327140)
- Where
- Egypt
- Volunteers
- 206 people
- Sponsor
- Zagazig University
Low Back Pain, Mechanical
Effectiveness of Chiropractic Application for Acute Low Back Pain
The aim of this project is to investigate the effectiveness of chiropractic application on patients who have undergone routine medication as a standard hospital treatment for mechanical low-back pain as described in the Clinical…
- Trial name
- NCT04110119
- Testing
- diclophenac sodium (75 mg, IM) and thiocolchicoside (4 mg, IM), Chiropractic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Medipol University
Ankle Sprain, Back Pain
Counterpain PXM Versus Diclofenac Versus Piroxicam
The goal of this clinical trial is to learn if a gel containing Piroxicam plus Counterirritant (warming/cooling ingredients) is as effective and safe as two other common anti-inflammatory gels for treating acute muscle, bone, and…
- Conditions
- Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee, Tennis Elbow
- Trial name
- NCT07475663
- Testing
- Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel)
- Where
- Indonesia
- Volunteers
- 180 people
- Sponsor
- Taisho Pharmaceutical Indonesia
Low Back Pain, Mechanical, Low Back Pain
Efficacy and Safety of S (+) - Ibuprofen in the Treatment of Mechanical Low Back Pain
The purpose of this study is to evaluate the efficacy of S (+) - ibuprofen compared to an active treatment for pain control in individuals with at least moderate acute mechanical low back pain.
- Conditions
- Low Back Pain, Mechanical, Low Back Pain, Acute Low Back Pain
- Trial name
- APS002/2020 (NCT04772781)
- Testing
- S (+) - Ibuprofen, Ibuflex®
- Where
- Brazil
- Volunteers
- 177 people
- Sponsor
- Apsen Farmaceutica S.A.
Low Back Pain
Probiotics for Modic Changes in Low Back Pain Patients
Probiotics for spinal inflammatory end-plate changes, so-called Modic changes, a randomised controlled study Modic changes are inflammatory end-plate changes primarily affecting the lower lumbar levels.
- Trial name
- NCT03100266
- Testing
- Probiotic, Inactive capsules
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Ole Kudsk Jensen
Chronic Low Back Pain
Effects of Strength Training in Chronic Low Back Pain Patients
Although it is known that chronic low back pain (CLBP) have a multifactorial etiology, the investigations about it are mostly specific to each investigation area, making difficult to understand this complex condition.
- Trial name
- NCT03326362
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ankylosing Spondylitis
16 Week Efficacy and 2 Year Long Term Safety and Efficacy of Secukinumab in Patients With Active Ankylosing Spondylitis
This study will assess the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who are intolerant to or have had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor therapy.
- Trial name
- MEASURE 1 (NCT01358175)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 67 sites in United States, Belgium and 12 more
- Volunteers
- 371 people
- Sponsor
- Novartis Pharmaceuticals
Spondyloarthritis
SKIPPAIN - Speed of Onset of SecuKinumab-Induced Relief From Pain in Patients With AxIal SpoNdyloarthritis
The purpose of the study was to evaluate the efficacy and safety of secukinumab 150 mg compared to placebo in the early management (Baseline to Week 8) of spinal pain, disease activity, fatigue, and predictability of disease…
- Trial name
- SKIPPAIN (NCT03136861)
- Testing
- AIN457
- Where
- 66 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 383 people
- Sponsor
- Novartis Pharmaceuticals
Breastcancer, Perioperative Pain
Efficacy of Serratus Posterior Intercostal Plane Block for Analgesia and Inflammatory Marker in Breast Surgery
To study the efficiacy of serratus posterior superior block in controlling perioperative breast cancer surgery pain and its effect on inflamatory markers.
- Conditions
- Breastcancer, Perioperative Pain, Inflammation
- Trial name
- NCT06502067
- Testing
- Analgesia mangement group A,B
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Spondylitis, Ankylosing
16-week Efficacy and 3-year Safety, Tolerability and Efficacy of Secukinumab in Active Ankylosing Spondylitis Patients
The purpose of this study was to generate 16-week efficacy data, as well as up to 3-year efficacy, safety and tolerability data in subjects with active AS despite current or previous NSAID, DMARD and/or anti-TNF therapy.
- Trial name
- MEASURE 3 (NCT02008916)
- Testing
- Secukinumab
- Where
- 57 sites in United States, Belgium and 8 more
- Volunteers
- 226 people
- Sponsor
- Novartis Pharmaceuticals
Postpartum Lumbopelvic Pain, Postpartum Pelvic Girdle Pain
Osteopathy in Postpartum Lumbopelvic Pain
Postpartum lumbopelvic pain is a common condition after childbirth and may affect pain levels, physical function, daily activities, and quality of life.
- Conditions
- Postpartum Lumbopelvic Pain, Postpartum Pelvic Girdle Pain, Postpartum Low Back Pain
- Trial name
- NCT07631949
- Testing
- Core Stabilization Exercises, Patient Education, Osteopathic Manipulative Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Halic University
Spondylarthritis, Uveitis, Anterior
Observational Prospective Turkish Inception Cohort of Uveitis and Spondyloarthritis
Spondyloarthritis (SpA) encompasses a group of inflammatory rheumatic diseases characterized by axial and/or peripheral arthritis, along with extra-articular manifestations such as enthesitis, dactylitis, uveitis, and skin…
- Trial name
- OPTICUS (NCT06720376)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Low Back Pain
Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain
This study tests the hypothesis that radial extracorporeal shock wave therapy (rESWT) in combination with the non-steroidal anti-inflammatory drug Celecoxib and the antispasmodic drug Eperisone (hereafter, "C-E drug therapy") is…
- Trial name
- NCT03337607
- Testing
- rESWT, Celecoxib, Eperisone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Osteoarthritis, Rheumatoid Nodule
Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease
Musculoskeletal disorders and degeneration represent injuries or pain in the body's joint ligaments, tendons, muscles, nerves, and skeletal elements that support extremities, spine and related tissues.
- Conditions
- Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy
- Trial name
- BRT (NCT03090672)
- Testing
- Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Robert W Alexander, MD
Postpartum Lumbopelvic Pain
Factors Associated With Disability in Postpartum Lumbopelvic Pain
Postpartum lumbopelvic pain may affect functional ability, daily activities, physical performance, psychological well-being, and health-related quality of life.
- Trial name
- NCT07809685
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Halic University