Clinical trials: Inflammation Biomarkers
Sepsis
Multi-marker INDex for the Risk Assessment of Sepsis in the Emergency departmenT (MINDSET)
The purpose of the study is to procure blood samples from patients ≥18 years of age who present to the Emergency Department (ED) with at least two of the diagnostic criteria for sepsis.
- Trial name
- MINDSET (NCT00472628)
- Testing
- Blood samples collected
- Where
- 24 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Exercise Recovery, Physical Performance Parameters
Effects of Pork Protein on Recovery Following Simulated Fireground Activity
The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in…
- Conditions
- Exercise Recovery, Physical Performance Parameters, Muscle Damage, Cognition
- Trial name
- PORK-FIRE (NCT07819565)
- Testing
- Pork-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals, Carbohydrate-Focused Lower-Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Late-Onset Neonatal Sepsis
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- EMERAUDE (NCT03299751)
- Testing
- Diagnostic performances of biomarkers combination
- Where
- 2 sites in France
- Volunteers
- 233 people
- Sponsor
- Hospices Civils de Lyon
Insulin Resistance, Inflammation Biomarkers
The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old
Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature.
- Conditions
- Insulin Resistance, Inflammation Biomarkers, Time Restricted Eating, Caloric Restriction
- Trial name
- NCT06911918
- Testing
- time restricted eating with caloric restriction, time restricted eating without caloric restriction, Caloric restriction without Time restricted eating
- Where
- Jordan
- Volunteers
- 120 people
- Sponsor
- University of Jordan
ACL - Anterior Cruciate Ligament Rupture, ACL Injury
Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction:
The proposed study will establish novel relationships between intra-articular mesenchymal stem cell (MSC) recruitment, synovial inflammation, biomarkers of cartilage degeneration and joint inflammation, clinical patient factors…
- Conditions
- ACL - Anterior Cruciate Ligament Rupture, ACL Injury, Healthy
- Trial name
- NCT03497780
- Testing
- Anterior cruciate ligament reconstruction
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Arrhythmogenic Cardiomyopathy
Diagnostic Contribution, Prognosis and Physiopathological Aspects in Arrhythmogenic Cardiomyopathy. (ACORE)
This study aims to identify novel inflammatory biomarkers in AC, whether in circulating blood, in situ or as imaging biomarkers to better understand the pathophysiology of the disease and then to determine contribution to the…
- Trial name
- ACORE (NCT05569356)
- Testing
- Prospective, Retrospective
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
The purpose of this study is to investigate the effect on airway inflammation and JAK1-associated signalling pathways of AZD4604 compared with placebo in participants with moderate-to-severe asthma.
- Trial name
- ARTEMISIA (NCT06435273)
- Testing
- AZD4604
- Where
- 18 sites in Canada, Denmark and 3 more
- Volunteers
- 36 people
- Sponsor
- AstraZeneca
Oxidative Stress, Inflammation Biomarkers
Effect of a Food Supplement with Natural Extracts of Cocoa, Amaranth Seed and Ginger in Overweight or Obese Patients
Clinical trial, randomized, double-blind, controlled with a placebo group, 40 patients between 18 and 60 years of age, with the presence of overweight, will be divided into parallel groups, group A cocoa, amaranth seed and…
- Conditions
- Oxidative Stress, Inflammation Biomarkers, Obesity and Overweight
- Trial name
- NCT06769035
- Testing
- Cocoa, amaranth seed and ginger, Amaranth seed, Cocoa
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Sepsis, Septic Shock
Sepsis ICU Gut Microbiome Analysis
Sepsis is a life-threatening condition in which the body's response to an infection damages its own organs. This study aims to understand how the bacteria living in the gut change during sepsis and whether patterns of gut…
- Trial name
- SIGMA (NCT07864818)
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Spinal Cord Injury, Acute
The Neuroinflammatory Response and Biomarkers in Acute Traumatic Spinal Cord Injury
The study is a prospective cohort study designed to assess the diagnostic and prognostic potential of biomarker measurement in acute traumatic spinal cord injury (TSCI), and to examine the neuroinflammatory response to acute TSCI.
- Trial name
- NCT03505463
- Testing
- Blood samples, Cerebrospinal fluid sample, Clinical examination
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Cognitive Impairment, Mild, Cognitive Dysfunction
MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients
Accumulating evidence indicates that inflammation is prominent both in the blood and central nervous system (CNS) of Alzheimer's disease (AD) patients.
- Conditions
- Cognitive Impairment, Mild, Cognitive Dysfunction, Amyloid Plaque, Neurodegeneration
- Trial name
- MCLENA-1 (NCT04032626)
- Testing
- Lenalidomide 10 mg
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Coronary Artery Disease, Peripheral Artery Disease
Synergistic Influence of Rivaroxaban on Inflammation and Coagulation Biomarkers in Patients With CAD and PAD on Aspirin Therapy
This is a phase IV, prospective biomarker study that will be conducted at Sinai Hospital of Baltimore. After screening for patients who were treated with aspirin, thirty patients will be treated with 81 mg enteric coated (EC)…
- Trial name
- NCT04059679
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet, Aspirin 81 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- LifeBridge Health
Cancer Survivors, Cardiotoxicity
In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors
The BREATHS trial aims to investigate whether overnight in-bedroom air filtration reduces inflammation and cardiac biomarkers in adult survivors of cancer who are at high risk for cardiovascular complications.
- Conditions
- Cancer Survivors, Cardiotoxicity, Cardiovascular Toxicity Induced by Antitumoral Drugs
- Trial name
- BREATHS (NCT06778122)
- Testing
- High efficiency particulate air filtration system (nightly administration), High efficiency particulate air filtration system (nightly and daily administration)
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University College, London
Sepsis
ACOD1 as a Prognostic Marker for Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with high morbidity and mortality worldwide. Reliable biomarkers are needed for early risk stratification and outcome prediction.
- Trial name
- NCT07533994
- Testing
- Blood draw for lab testing.
- Where
- 2 sites in China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Infections, Sepsis
A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children
A case-control cohort study to develop and validate the performance of a whole blood gene expression test to distinguish sepsis infection from uninfected systemic inflammatory response syndrome cases in symptomatic adults and…
- Conditions
- Infections, Sepsis, SIRS
- Trial name
- NCT05142813
- Testing
- Diagnostic Test: Blood specimen collection
- Volunteers
- 1,100 people
- Sponsor
- mProbe Inc.
Sepsis, Immune Deficiency
Presepsin as Detective Marker of Sepsis in Immunodeficiency ICU Patients
This is an observational study to evaluate the diagnostic and prognostic value of presepsin in the critically-ill immunocompromise patients.
- Trial name
- PREICU (NCT03881566)
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- Jongmin Lee
Septic Shock
Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers
Sepsis induces hemostatic disorders due to the exessive or inappropriate activation of inflammation, which could lead either to hypercoagulability or hypocoagulability.
- Trial name
- COASEPT (NCT02692053)
- Testing
- blood sampling
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Inflammation, C-reactive Protein
What is the Effect of Increased Consumption of Fruit Juice on Exercise Capacity and Inflammatory Biomarkers?
Dietary patterns and physical inactivity common in Western societies have been associated with chronic low-grade inflammation and an increased risk of non-communicable health conditions.
- Conditions
- Inflammation, C-reactive Protein, Exercise Capacity
- Trial name
- NCT07862049
- Testing
- Active Fruit Juice Intervention, Control Fruit Juice Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Rheumatoid Arthritis, Psoriasis
The Anti-inflammatory Effects of Harkány Medicinal Water
The study aims to provide evidence on the effectiveness of Harkány medicinal water in psoriatic and rheumatoid arthritis patients using subjective and objective methods.
- Trial name
- NCT04275206
- Testing
- Harkány medicinal water
- Where
- Hungary
- Volunteers
- 350 people
- Sponsor
- University of Pecs
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS