Clinical trials: Infertility/Sterility
Infertility
Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years
Women over 35 years old are likely to suffer from impaired oocyte repair capacity. Teratozoospermia is a condition reflects morphological affection of sperm. These spermatozoa would add an extra burden on the oocyte after ICSI.
- Trial name
- NCT03666364
- Testing
- Sperm preparation for ICSI
- Where
- 3 sites in Egypt
- Volunteers
- 1,400 people
- Sponsor
- Ibn Sina Hospital
Infertility, Obesity
Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)
The present study aims to elucidate if there is a metabolomic profile alteration in the embryos of obese women in order to understand if the reduced implantation rate observed in these patients is directly related to this factor.
- Trial name
- NCT01448863
- Testing
- Culture medium metabolomic analysis
- Where
- 2 sites in Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
ICSI AZOOSPERMIA VARICOCELE
Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia
This study will include cryopreserved sperm from infertile azoospermic men, with proven diagnosis of varicocele (clinical \& sonographic), which will be used for ICSI in an ART program in Sohag.
- Trial name
- NCT02306499
- Testing
- ICSI
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Sohag University
Infertility Assisted Reproductive Technology, Sexual Behavior
Effects of Infertility and Assisted Reproductive Technology on Sexual Function and Behavior
This cross-sectional observational study examines how infertility and the use of assisted reproductive technology (ART) are related to sexual function and sexual behaviors in women seeking fertility treatment.
- Conditions
- Infertility Assisted Reproductive Technology, Sexual Behavior, Sexual Function, Sexual Dysfunction and Infertility
- Trial name
- NCT07376109
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Life Style, Fertility Disorders
COaching Lifestyle Intervention for FErtility
In Finland, every third woman is overweight (BMI>25) and 11,5% obese (BMI>30). Cohort and national studies reveal that 46% of fertile-aged men have BMI≥25 and 20% BMI≥30.
- Trial name
- COLIFE (NCT04589793)
- Testing
- Life Style
- Volunteers
- 1,560 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Infertility
The Pharmacokinetic and Bioavailability of GenSci094 Before and After a Change in Manufacturing Site
The bioavailability study is intended to evaluate the pharmacokinetic (PK) characteristics and the bioavailability of the two formulations in humans before and after the change of production site, in order to assess the possible…
- Trial name
- NCT06095206
- Testing
- GenSci094
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Infertility Associated With Endometriosis
Reproductive Outcome of EM Treated by GnRH-a Associated With Laparoscopy
This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery.
- Trial name
- NCT02779387
- Testing
- Goserelin Acetate
- Volunteers
- 1,184 people
- Sponsor
- Peking University People's Hospital
Sterility, Female
Comparison Between 2 Techniques for Bilateral Salpingectomy
A comparison between 2 techniques for bilateral salpingectomy during cesarean section. Primary outcomes are total operative time and bilateral completion of the randomized procedure.
- Trial name
- NCT03788421
- Testing
- LIGASURE, Clamping and suturing
- Where
- Israel
- Volunteers
- 51 people
- Sponsor
- Rambam Health Care Campus
Infertility, Male
Varicocele Repair for Men Undergoing IVF/ICSI
For infertile men undergoing intracytoplasmic sperm injection (ICSI), data from retrospective studies suggested that varicocele repair may be beneficial and associated with improved livebirth and pregnancy rates, however, its…
- Trial name
- Varicocele (NCT04608864)
- Testing
- varicocelectomy
- Volunteers
- 2,000 people
- Sponsor
- Al-Yasmeen Fertility and Gynecology Center
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
Liver Stiffness And Steatosis Assessment In Women With Polycystic Ovary Syndrome Using Fibroscan
Polycystic Ovary Syndrome (PCOS) is a complex endocrine and metabolic disorder prevalent among women of reproductive age. It is closely associated with insulin resistance, obesity, and metabolic dysfunction, often leading to…
- Trial name
- NCT07027332
- Testing
- FibroScan® (Echosens, Paris, France)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility, Mental Health
Patient Empowerment Project (PEP) Study
The Patient Empowerment Project (PEP) will be integrated into the intake process at a fertility clinic to prepare clinical staff for any patient sensitivities or preferences and provide extra support if needed.
- Trial name
- PEP (NCT07725458)
- Testing
- Patient Empowerment Program (PEP)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Inception Fertility Research Institute, LLC
Female Infertility, Reproductive Health
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Female Fertility
This study evaluates the effects of a daily dietary supplement (WeNatal For Her) on markers of female fertility, reproductive health, and sexual health over three menstrual cycles.
- Conditions
- Female Infertility, Reproductive Health, Fertility, Hormonal Imbalance
- Trial name
- NCT07740187
- Testing
- WeNatal For Her Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Infertility
RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders
The purpose of this study is compare two commonly-used medication protocols ( low-dose clomiphene citrate and high dose gonadotropin protocols) for the treatment of patients with diminished ovarian reserve (decreased number of…
- Trial name
- CLOVANT (NCT01577199)
- Testing
- Low-dose Clomiphene, High dose gonadotropins
- Sponsor
- Weill Medical College of Cornell University
Infertility
Cleave-stage Transfer on Day 3 Versus Day 5 Transfer When Only One Embryo Available
When only one embryo is available after in vitro fertilization, the option is to transfer either day 3 or day 5. There is no randomized trial compared the day 3 to day 5 for this subgroup.
- Trial name
- Cleave-blast (NCT04210414)
- Testing
- Embryo transfer
- Where
- 3 sites in Egypt
- Volunteers
- 83 people
- Sponsor
- Ibn Sina Hospital
Infertility, Female
Laparoscopy in Failed IVF
Current in-vitro fertilization (IVF) consumers are enjoying better success rates than early seekers, but only about a quarter of IVF cycles result in a live birth and many patients remain infertile after multiple IVF attempts.
- Trial name
- NCT06165484
- Testing
- laparoscopy and hysteroscopy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fertility Disorders, Fertility Issues
Menstrual Phase Endometrial Scratch in IUI Cycles
Patients undergoing treatment with intrauterine insemination (IUI) will be randomized to receive an endometrial scratch or sham procedure during the menstrual phase of the treatment cycle.
- Trial name
- NCT04641598
- Testing
- Endometrial Scratch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Varicocele, Male Infertility
Zonulin Levels in Varicocele Patients
This prospective cross-sectional observational study was designed to evaluate serum and seminal plasma zonulin levels in infertile men with clinically diagnosed varicocele and compare them with those in infertile men without…
- Conditions
- Varicocele, Male Infertility, Zonulin
- Trial name
- VARIZON (NCT07748104)
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Süleyman Tümer Çalışkan
Infertility
Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphene Citrate to Improve Pregnancy Rate in PCO Patients
To evaluate the effect of oral Phytoestrogen or Isosorbid mononitrate or N-acetyl cysteine as an adjuvant to clomiphene citrate on induction of ovulation and pregnancy outcomes in patients with PCOS.
- Trial name
- NCT02493933
- Testing
- Phytoestrogens, Isosorbid mononitrate, N-acetyl cysteine
- Volunteers
- 240 people
- Sponsor
- Kasr El Aini Hospital
Osteo Arthritis Knee
pAF for the Treatment of Osteoarthritis
This is a Phase I/II Randomized Double-Blinded Standard of Care (Corticosteroid) vs. Sterile Amniotic Fluid for Osteoarthritis
- Trial name
- NCT04886960
- Testing
- Amniotic Fluid Injection, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah