Clinical trials: Infectious Morbidity
HIV/AIDS, Infant Morbidity
Adaptation and Evaluation of the PMTCT CSC in Dedza and Ntcheu Districts, Malawi
This CDC-funded study sought to evaluate the effect of an adapted Community Score Card Approach on maternal retention in ART, maternal retention across the PMTCT service cascade, and the uptake of early infant diagnosis services…
- Trial name
- NCT04372667
- Testing
- Community score card approach
- Where
- Malawi
- Volunteers
- 1,233 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Infection; Cesarean Section, Surgical Wound Infection
Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity
Previous studies have demonstrated that patients who undergo surgery while they under general anesthesia have fewer wound infections if they receive higher concentrations of oxygen but this has never been studied in women who are…
- Conditions
- Infection; Cesarean Section, Surgical Wound Infection, Endometritis
- Trial name
- Peri-Op (NCT00603603)
- Testing
- 80% inhaled oxygen via non-rebreather mask, 30% inhaled oxygen via nasal cannula
- Where
- United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Elective Colorectal Surgery
Intravenous Versus Combined Oral and Intravenous Antimicrobial Prophylaxis for the Prevention of Surgical Site Infection in Elective Colorectal Surgery
To assess the effects of a combined antimicrobial prophylaxis using oral ornidazole (the day before surgery) and intravenous cephalosporin (before surgical incision) with that of intravenous cephalosporin alone (standard of care)…
- Trial name
- COMBINE (NCT02618720)
- Testing
- ornidazole
- Where
- France
- Volunteers
- 920 people
- Sponsor
- University Hospital, Clermont-Ferrand
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Diseases of the Urinary System, Schistosomiasis Haematobia
Urinary Schistosomiasis Infection
The purpose of this study is to determine what causes some people to become sick, and others not, when they are infected with the parasite Schistosoma haematobium, also known as Bilharzia.
- Trial name
- NCT00138450
- Where
- Kenya
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bladder Cancer, Oncology
Influence of Immune Nutrition Diet on 90-Day Outcomes in Patients Undergoing Radical Cystectomy
This is a randomised double-blinded placebo-controlled phase IV trial with two parallel treatment groups receiving either immune nutrition diet (IND) or conventional diet for 2weeks peri-radical cystectomy.
- Conditions
- Bladder Cancer, Oncology, Infection, Complication
- Trial name
- NCT03147586
- Testing
- Bio-tech and omega-3 plus
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
COVID-19
COVIDOM: Longterm Morbidity of SARS-CoV-2 Infection and COVID-19 Disease - Consequences for Health Status and Quality of Life
COVID-19 is a novel disease caused by SARS-CoV-2 that primarily affects the lungs but also various other organs of the body already in early stages of the disease.
- Trial name
- NAPKON-POP (NCT04679584)
- Testing
- Observation of different courses of SARS-CoV-2 infection in different phases (acute vs. post-acute) and settings
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Schleswig-Holstein
Genital Herpes Simplex, Maternal Morbidity
Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity
Severe Maternal Morbidity (SMM) has been associated with maternal mortality, fetal risk, and long-term maternal risk. African American (AA) women are at consistently higher risk than White women.
- Conditions
- Genital Herpes Simplex, Maternal Morbidity, Racial Disparities
- Trial name
- PCORISMM (NCT05429346)
- Where
- United States
- Volunteers
- 339,000 people
- Sponsor
- Kaiser Permanente
TB - Tuberculosis, TB
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity.
- Conditions
- TB - Tuberculosis, TB, TB Infection
- Trial name
- TB Pure (NCT07164742)
- Testing
- 8 week (short arm) Intervention - pulmonary rehabilitation, 24 week (long arm) Intervention - pulmonary rehabilitation
- Where
- 2 sites in India
- Volunteers
- 690 people
- Sponsor
- Johns Hopkins University
Diarrhea, Respiratory Infection
Impact of Zinc Supplementation in Low Birth Weight Infants on Severe Morbidity, Mortality and Zinc Status: A Randomized Controlled Trial
There are currently no interventions available to substantially reduce the incidence of low birth weight (LBW) apart from increasing the age at marriage, maternal iron supplementation and possibly improved energy intakes.
- Conditions
- Diarrhea, Respiratory Infection, Low Birth Weight
- Trial name
- NCT00272142
- Testing
- Zinc
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
SARS CoV 2 Infection, Cancer
Mortality of Cancer Surgery During SARS CoV2 Pandemic
The impact of cancer surgery during covid epidemic is not clear. The published reports show contradictory findings that extend from no change in mortality to increased mortality, further no data on exposure and outcome of health…
- Trial name
- NCT05240378
- Testing
- Surgery
- Where
- India
- Volunteers
- 1,576 people
- Sponsor
- Banaras Hindu University
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Morbidity Study
The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic…
- Trial name
- MORDORMorb (NCT02048007)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 72,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, AIDS
The DC Cohort Longitudinal HIV Status Neutral Study
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for patients diagnosed with Human Immunodeficiency Virus/Acquired Immune…
- Trial name
- DC Cohort (NCT01206920)
- Where
- 14 sites in United States
- Volunteers
- 19,000 people, healthy volunteers welcome
- Sponsor
- George Washington University
Critically Ill, Enterobacteriaceae Infections
Infections and Colonization With the Third Group of Enterobacteriaceae in the Intensive Care Unit
There is a lack of data whether colonization and infection with Enterobacteriaceae of the third group (EB3) affect the outcomes for ICU patients.
- Conditions
- Critically Ill, Enterobacteriaceae Infections, Antibiotic Resistant Infection
- Trial name
- EB3REA (NCT04528043)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Central Hospital, Nancy, France
Acute Cholecystitis
Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy
Acute cholecystitis is frequent in the elderly, or in patients with gall stones. Most cases of severe or recurrent cholecystitis need surgery as final therapy.
- Trial name
- ACDC (NCT00447304)
- Testing
- moxifloxacin, cholecystectomy
- Where
- Germany
- Volunteers
- 644 people
- Sponsor
- Heidelberg University
Fournier Gangrene, Fournier's Gangrene of Penis
Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients
Background: Fournier's gangrene it's a necrotizing infection of the genital area, with high morbidity and mortality. The site of infection its the origin of the necrotizing fasciitis.
- Conditions
- Fournier Gangrene, Fournier's Gangrene of Penis, Fournier's Gangrene of Scrotum
- Trial name
- NCT03443544
- Testing
- Aggressive debridement
- Where
- Mexico
- Volunteers
- 121 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Maternal Sepsis, Infections
EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 2)
Sepsis is the second leading cause of maternal death in the U.S. For racial and ethnic minoritized birthing people, especially those who are Black, living in poverty, and from underserved communities, labor and postpartum are…
- Trial name
- NCT06148532
- Where
- United States
- Volunteers
- 400,000 people
- Sponsor
- Columbia University
SARS CoV 2 Infection
Impact of the Postponement of Surgery on Postoperative Morbidity After Sars-cov-2 Infection
The deployment of vaccination against SARS-CoV-2 from 2021 led to a modification in June 2021of previous recommendations concerning the postponing scheduled surgery suggesting local adaptations of this delay if epidemic…
- Trial name
- DROMIS-22 (NCT05336110)
- Testing
- Postponing surgery
- Where
- 40 sites in France
- Volunteers
- 5,189 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Polytrauma, Hypothermia
Forced Air Versus Endovascular Warming in Polytrauma Patients
Trauma is the leading cause of death in young adults, bleeding and infection are major concomitant problems. We test the hypothesis that fast, perioperative warming with an endovascular catheter versus forced air warming may…
- Trial name
- FAEWPP (NCT00555126)
- Testing
- Forced Air Warming, Warming with endovascular catheter + forced air warming
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna