Clinical trials: Infections, Upper Respiratory Tract
COVID-19, Vaccines
Safety and Immunogenicity of AdCLD-CoV19-1 OMI as a Booster: A SARS-CoV-2 (COVID-19) Preventive Vaccine
The safety and immunogenicity of AdCLD-CoV19-1 OMI (5.0x10^10 VP (0.5 mL)/dose/Vial) administered as a booster in healthy adults aged 19 years old and above will be evaluated.
- Trial name
- NCT05576623
- Testing
- AdCLD-CoV19-1 OMI (Part A), AdCLD-CoV19-1 OMI (Part B)
- Where
- 7 sites in South Korea
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Cellid Co., Ltd.
Bronchiolitis, Lower Respiratory Tract Infection
Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial
The goal of this clinical trial is to find out at which lower limit for saturation (amount of oxygen in the blood) we can best give extra oxygen to children that have been admitted for shortness of breath.
- Conditions
- Bronchiolitis, Lower Respiratory Tract Infection, Bronchial Hyperreactivity
- Trial name
- OxyKids (NCT06016244)
- Testing
- Oxygen saturation threshold
- Where
- 9 sites in Netherlands
- Volunteers
- 566 people
- Sponsor
- Spaarne Gasthuis
Pneumonia, Lower Respiratory Tract Infection
A Clinical Pathway for Nursing Home Acquired Pneumonia
Nursing home residents are frequently transferred to hospital for management of pneumonia. This often leads to hospital related complications and is a burden on the acute care health system.
- Trial name
- NCT00157612
- Testing
- a clinical pathway nursing home acquired pneumonia
- Volunteers
- 680 people
- Sponsor
- McMaster University
Upper Respiratory Tract Infections
Reducing Unnecessary Antibiotic Prescriptions in Primary Healthcare in Saskatchewan by Identifying High Prescribers
Approximately 90% of antibiotics are prescribed in primary healthcare (PHC) in Canada (Public Health Agency of Canada, 2020), making this an important sector for antimicrobial stewardship.
- Trial name
- NCT05557214
- Testing
- Audit and Feedback Letter
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Upper Respiratory Infection
Point of Care Respiratory Pathogen Testing for Antibiotic Stewardship in Primary Care
The goal of this study is to understand the use of point of care (POC) testing devices in primary care offices to help clinicians diagnose and appropriately treat patients who have symptoms of upper respiratory infections (URIs).
- Trial name
- PROTECT (NCT06765135)
- Testing
- Clinician Survey, Focus Group, Biofire Spotfire Respiratory (R) panel
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- University of Pennsylvania
Influenza, Human, Acute Respiratory Infection
Efficacy and Safety of Ingavirin®, Syrup, 30 mg/5 ml, in Children With Influenza and Other Acute Respiratory Viral Infections
The study is planned to evaluate the therapeutic efficacy and safety of Ingavirin®, syrup, 30 mg/5 ml, in the treatment of influenza or other acute respiratory infections in children from 6 months to 2 years compared with placebo.
- Conditions
- Influenza, Human, Acute Respiratory Infection, Common Cold
- Trial name
- NCT05269290
- Testing
- Ingavirin®, syrup, 30 mg/5 ml
- Where
- 8 sites in Russia
- Volunteers
- 240 people
- Sponsor
- Valenta Pharm JSC
Acute Upper Respiratory Tract Infections
Trial of Post-Dated Delayed Antibiotic Prescriptions
Delayed prescriptions have been shown to lower antibiotic use for upper respiratory tract infections (which are mostly viral). This trial will test the hypothesis that if the clinician post-dates the delayed prescription by 2…
- Trial name
- NCT02732847
- Testing
- A delayed prescription dated 2 days after clinical office visit, Usual Dated
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- Memorial University of Newfoundland
Community Acquired Pneumonia, Hospital Acquired Pneumonia
HOME FIRST Pilot: a Study of Early Supported Discharge in Patients With Lower Respiratory Tract Infections
HOME FIRST (Home Followed - up with Infection Respiratory Support Team) is an early supported discharge scheme. It will enable patients with lower respiratory tract infection (LRTI) to be provided with high quality safe…
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Lower Respiratory Tract Infection
- Trial name
- HOMEFIRST (NCT02454114)
- Testing
- HOMEFIRST, Standard Hospital Care
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Influenza
Study to Evaluate Immunogenicity & Safety of an Investigational Influenza Vaccine in Adults
The objective of this study is to evaluate the immunogenicity and safety of GSK Biologicals' investigational vaccine GSK2340272A.
- Trial name
- NCT00975884
- Testing
- GSK investigational vaccine GSK2340272A
- Where
- 5 sites in France
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Common Cold, Respiratory Tract Infections
The Effect of Zinc Acetate Lozenges on the Rate of Recovery From the Common Cold
A randomized parallel-group two arm superiority trial with an allocation ratio 1:1, both participants and investigators blinded.
- Trial name
- HelZinki (NCT03309995)
- Testing
- Lozenges
- Where
- Finland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
COVID 19
Convalescent Plasma for COVID-19 Patients (CPCP)
Prior findings in various viral respiratory diseases including SARS-CoV-related pneumonia suggest that convalescent plasma can reduce mortality, although formal proof of efficacy is still lacking.
- Trial name
- CPCP (NCT04521036)
- Testing
- Convalescent Plasma as Therapy for Covid-19 patients
- Where
- Vietnam
- Volunteers
- 4 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Cough
Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment
The purpose of this study is evaluate if efficacy of a combination dose of oxomemazine, guaifenesin and potassium iodate is superior than guaifenesin monotherapy in acute cough treatment.
- Trial name
- NCT01257243
- Testing
- Syrup of oxomemazine, guaifenesin and potassium iodate, Syrup of guaifenesin
- Where
- Brazil
- Volunteers
- 260 people
- Sponsor
- EMS
Coronavirus Disease 2019
Clinical Study on the Immune Program of Recombinant Novel Coronavirus（COVID-19) Vaccine (CHO Cell)
Popular topic：Clinical study on the immune program of recombinant Novel Coronavirus (COVID-19) vaccine (CHO cell). Research purpose:Main purpose: To evaluate the immunogenicity of recombinant novel coronavirus vaccine (CHO cells)…
- Trial name
- NCT05128643
- Testing
- Recombinant novel coronavirus vaccine (CHO cell)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Cough
Transpulmin Suppository and Guaiacol Compared to Transpulmin Syrup in Pediatric Participants With Productive Cough
This study evaluates the non-inferiority of Suppository Transpulmin and Suppository Guaiacol compared to Transpulmin Syrup in the treatment of cough with secretion of infectious origin in children between two and six years old.
- Trial name
- Transpulmin (NCT02581397)
- Testing
- Transpulmin suppository, Guaiacol suppository, Transpulmin syrup
- Where
- Brazil
- Volunteers
- 270 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Acute Bacterial Sinusitis
Single Use Device Endoscopy for the Diagnosis of Acute Bacterial Rhinosinusitis in Primary Care
This is a pilot study to assess the first time use of the JGG endoscope® in humans and in primary care. The JGG endoscope® is attached to a Heine® otoscope and allows to inspect and to collect samples from the middle meatus of…
- Trial name
- Sinus-Endo (NCT03766568)
- Testing
- JGG endoscope(R)
- Where
- 6 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Dominik Glinz
Pneumonia, Bronchiolitis
Diagnosing Respiratory Disease in Children Using Cough Sounds
The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in diagnosis of pneumonia and other respiratory conditions (bronchiolitis, asthma/reactive airway disease, croup, upper or…
- Conditions
- Pneumonia, Bronchiolitis, Asthma, Croup
- Trial name
- SMARTCOUGH-C (NCT02973282)
- Testing
- Recording of Infants and Children's Cough Sounds
- Where
- 3 sites in United States
- Volunteers
- 1,245 people
- Sponsor
- ResApp Health Limited
COVID-19
Sleep Quality and Quality of Life in Coronavirus 19 Disease ( COVID 19) Patients
To study the impact of COVID 19 infection on sleep habit as regards quality of sleep, emergence of insomnia. To assess quality of life in patients after COVID 19 infection.
- Trial name
- NCT05148858
- Volunteers
- 100 people
- Sponsor
- Assiut University
Upper Respiratory Tract Infection, Lower Respiratory Infection
Bioequivalence Study of Azithromycin Capsule and Reference Formulation Sumamed * in Healthy Adult Subjects in China
Main research purpose To investigate the pharmacokinetics of the test preparation azithromycin capsule and the reference preparation azithromycin capsule (Sumamed®) in Chinese healthy adult subjects by single oral administration…
- Conditions
- Upper Respiratory Tract Infection, Lower Respiratory Infection, Skin Infection, Subcutaneous Tissues Infection
- Trial name
- NCT06149117
- Testing
- test product (T) azithromycin capsule and reference product (R) azithromycin capsule "Sumamed®"
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
COVID-19
The Immunogenicity, Safety, and Effectiveness of the COVID-19 Inactivated Vaccine
To fast respond the coronavirus disease of 2019 (COVID-19) pandemic, the Indonesian government has launched "Vaksinasi Gotong Royong" (a mutual cooperation vaccination program) in which any company/legal entity/business entity…
- Trial name
- NCT05126550
- Testing
- SARS-CoV-2 vaccine (Vero cell) inactivated
- Where
- 4 sites in Indonesia
- Volunteers
- 435 people, healthy volunteers welcome
- Sponsor
- PT. Kimia Farma (Persero) Tbk