Clinical trials: Infection, Parasite
Malaria
Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients
The primary objective of this Phase III clinical study is to demonstrate the efficacy of the fixed combination of pyronaridine artesunate (PA) granule formulation (60:20 mg; pediatric PYRAMAX®) by showing a PCR-corrected adequate…
- Trial name
- NCT00541385
- Testing
- pyronaridine artesunate, arthemeter lumefantrine
- Where
- 8 sites in Burkina Faso, Côte d’Ivoire and 6 more
- Volunteers
- 535 people
- Sponsor
- Medicines for Malaria Venture
African Trypanosomiasis, African; Trypanosomiasis, West
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure
The study validates the diagnostic performance of cerebrospinal fluid neopterin quantification and of blood and cerebrospinal fluid trypanosomal spliced leader RNA detection for assessing outcome after treatment of human African…
- Conditions
- African Trypanosomiasis, African; Trypanosomiasis, West, Sleeping Sickness; West African, Trypanosoma Brucei Gambiense; Infection
- Trial name
- DiTECT-WP4 (NCT03112655)
- Testing
- RNA and neopterin detection
- Where
- Democratic Republic of the Congo
- Volunteers
- 88 people
- Sponsor
- Institut de Recherche pour le Developpement
Malaria Diagnosis, Malaria,Falciparum
Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections
A systematic review assessing the role, appropriateness and benefits of the active case detection strategy, both proactive and reactive, in low malaria transmission settings.
- Trial name
- NCT03511443
- Testing
- hsRDT
- Where
- Burma
- Volunteers
- 1,980 people, healthy volunteers welcome
- Sponsor
- University Research Co, LLC
Toxocara Infection
The Effectiveness of Albendazole Treatment Among Infected Toxocara Children
This study consists 2 phases. The first phase will conduct a cross-sectional study to determine the infection rate of Toxocariasis larvae, describe the clinical and paraclinical characteristics, identify risk factors related to…
- Trial name
- NCT05208333
- Testing
- Albenza 200Mg Tablet
- Volunteers
- 960 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Leishmaniasis
LEISH-F3 + GLA-SE and the LEISH-F3 + MPL-SE Vaccine
Investigational products: LEISH-F3 (recombinant protein antigen) + GLA-SE (adjuvant) leishmaniasis vaccine and LEISH-F3 (recombinant protein antigen) + MPL-SE (adjuvant) leishmaniasis vaccine.
- Trial name
- NCT01751048
- Testing
- GLA-SE, LEISH-F3, MPL-SE
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Efficacy of Amodiaquine-artesunate in Children Aged 6-59 Months With Uncomplicated P. Falciparum Malaria
We will be studying the clinical efficacy of amodiaquine-artesunate currently being studied in an intermittent preventive therapy in infants (IPTi)trial in the same area in order to correlate preventive efficacy seen in IPTi with…
- Trial name
- IPTi DRWG (NCT00425763)
- Testing
- AQAS
- Where
- Kenya
- Volunteers
- 110 people
- Sponsor
- Centers for Disease Control and Prevention
Severe Malaria
Malaria Treatment With Injectable ArteSunate
The MATIAS study aims to demonstrate through limited scope implementation studies how injectable artesunate may be progressively rolled out nationwide in the Democratic Republic of the Congo as the preferred treatment for severe…
- Trial name
- MATIAS (NCT01828333)
- Testing
- No intervention
- Where
- 9 sites in Democratic Republic of the Congo
- Volunteers
- 350 people
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria
Age of Exposure and Immunity to Malaria in Infants
The overall objective is to evaluate the effect of exposure to Plasmodium (P.) falciparum erythrocytic stage antigens during different periods of infancy on the development of naturally acquired immunity (NAI).
- Trial name
- NCT00231452
- Testing
- Sulfadoxine-pyrimethamine (SP) + Artesunate (AS)
- Where
- Mozambique
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Asthma
Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma
There has been considerable debate over the last 30 years about the interaction between asthma and parasitic infection. It has been suggested that at least part of the reason for the increasing prevalence of asthma in the…
- Trial name
- NCT00469989
- Testing
- Infection with hookworm larvae
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Necator Americanus Infection
Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
Four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae once and will retain infection for up to 2 years.
- Trial name
- CHHIL (NCT03126552)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Malaria
Single-Blind, Placebo-Controlled, Randomized Study Testing Single Ascending Doses Of GSK369796 In Healthy Subjects
This study will examine safety of single doses of GSK369796 in healthy subjects, along with some test to examine how quickly GSK369796 gets in your blood, and how long it takes your body to get rid of it.
- Trial name
- NCT00675064
- Testing
- GSK369796
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pandemic, COVID-19, Demodex Infestation
Could Wearing Face Mask Have Affected Demodex Parasite
This study aimed to examine whether wearing masks by healthy individuals during the Covid-19 pandemic created an environment for Demodex mites, by comparing it with the control group.
- Trial name
- NCT06185699
- Testing
- standard superficial skin biopsy (SSSB)
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Nurhan Döner Aktaş
Malaria,Falciparum, Malaria
CHILD (Child Health and Infection With Low Density) Malaria
This trial will assess the long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania
- Trial name
- NCT05567016
- Testing
- Active case detection using molecular testing (ACDm), Passive case detection using molecular testing (PCDm), Control (standard of care)
- Where
- Tanzania
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Dose Escalation PfSPZ-CVac
Background: People get malaria from bites from infected mosquitos. Researchers are studying a vaccine strategy. They will give people malaria parasites by injecting them with live infectious malaria parasites with antimalarial…
- Trial name
- NCT03083847
- Testing
- Chloroquine Phosphate, Pyrimethamine, Sanaria PfSPZ Challenge
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Celiac Disease
Desensitising Celiac Disease Patients With the Human Hookworm
We have established that the hookworm Necator americanus (Na) dramatically alters the local and systemic immune landscape of the infected human host.
- Trial name
- NaCeD (NCT01661933)
- Testing
- Necator americanus
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- The Prince Charles Hospital
Malaria
Malaria in Strasbourg University Hospital
The primary purpose is to describe the anamnestic, clinical, biological, and therapeutic characteristics of imported malaria in people originated from endemic areas.
- Trial name
- ACMUS (NCT03594084)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
Visceral Leishmaniasis
LAMP Assay for the Diagnosis of Visceral Leishmaniasis
This study will evaluate the of the loop-mediated amplification assay (LAMP) as a diagnostic as well as a Test-of-Cure (ToC) for visceral leishmaniasis (VL) in an endemic area in Ethiopia.
- Trial name
- EvaLAMP (NCT04003532)
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Prof. Dawit Wolday
Malaria
An Extension to Study MALARIA-055 PRI (NCT00866619) to Evaluate the Long-term Efficacy, Safety and Immunogenicity of GSK Biologicals' Candidate Malaria Vaccine in Infants and Children in Africa
The purpose of this study is to conduct long-term surveillance for efficacy, safety and immunogenicity of the GSK Biologicals RTS,S/AS01E candidate Plasmodium falciparum malaria vaccine in infants and children in Africa following…
- Trial name
- NCT02207816
- Testing
- Blood sampling, Malaria Vaccine 257049 (MALARIA-055 PRI), Meningococcal C Conjugate Vaccine (MALARIA-055 PRI)
- Where
- 3 sites in Burkina Faso, Kenya and 1 more
- Volunteers
- 3,084 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria,Falciparum
Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde
Artesunate-amodiaquine and artemether-lumfantrine are currently being used for the treatment of uncomplicated Plasmodium falciparum in Cameroon.
- Trial name
- NCT04565184
- Testing
- Artesunate-amodiaquine combination, Artemether, Lumefantrine Drug Combination
- Where
- Cameroon
- Volunteers
- 242 people
- Sponsor
- University of Yaounde 1
Malaria (Plasmodium Falciparum), Malaria Falciparum
Safety and PK of MMV371 LAI in Healthy Adults and Adolescents in Rwanda
This Phase 1b study will assess the safety, tolerability and pharmacokinetics (PK, this measures the levels of study drug in the body) of a single injection of MMV371 in healthy adult and adolescent participants in Rwanda.
- Conditions
- Malaria (Plasmodium Falciparum), Malaria Falciparum, Malaria Infection, Malaria Prophylaxis
- Trial name
- NCT07548021
- Testing
- MMV371
- Where
- Rwanda
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture