Clinical trials: Infection, Human Immunodeficiency Virus
HPV Infection
The Study for the "Cervical Cancer Screening and Treatment Algorithms Study Using HPV Testing in Africa"
The main objectives of CESTA are (1) to compare the efficacy of two cervical cancer screening algorithms: HPV test followed by visual inspection with acetic acid (VIA) and treatment (HPV + VIA + treat) and HPV test followed by…
- Trial name
- CESTA (NCT04794660)
- Testing
- HPV DNA Test, VIA triage test, Treatment by ablative treatment
- Where
- 3 sites in Senegal, South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
HIV Infections
Evaluating the Safety and Immune Response to Two HIV Vaccine Regimens in Healthy, HIV-Uninfected Adults in the United States and South Africa
The purpose of this study is to evaluate the safety and immune response to two different HIV vaccine regimens in healthy, HIV-uninfected people in the United States and South Africa.
- Trial name
- NCT01927835
- Testing
- DNA-HIV-PT123 vaccine, NYVAC-HIV-PT1 vaccine, NYVAC-HIV-PT4 vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Effectiveness of a Mobile-based HIV Prevention Intervention Involving Incentive Policy for Doctors in Liangshan, China
This study will be carried out in Liangshan Yi Autonomous Prefecture, Sichuan province, China, using a single-blinded randomized controlled trial design to measure the effects of a mobile-based HIV-related information…
- Trial name
- NCT05015062
- Testing
- Mobile-based HIV-related educational message delivery, Incentive policies evaluation
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Peking University
HIV Prevention, Substance Use
Host Led Harm Reduction Approach Among Men Who Have Sex With Men Who Engaged in Chemsex in Bangkok, Thailand: A Pre-Implementation Study
This study evaluates the pre-implementation phase of a host-led harm reduction model for men who have sex with men (MSM) engaging in chemsex in Bangkok, Thailand, focusing on understanding harms, contexts, and needs to develop a…
- Conditions
- HIV Prevention, Substance Use, Mental Health, Sexually Transmitted Infections (STIs)
- Trial name
- HAMMOCK (NCT07512869)
- Testing
- Self-administered questionnaire assessment, Semi-structured in-depth interviews (IDIs), Development and refinement of harm reduction model
- Where
- Thailand
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Human Immunodeficiency Virus Infection, Hepatitis C
Comparison of Plasma & SMARTplasma for Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) Antibody Testing
The purpose of this study is to compare the results for HIV and/or Hepatitis C Virus antibody testing when using routine plasma versus SMARTplasma from the same blood sample.
- Trial name
- NCT01447680
- Where
- 7 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- G & W Laboratories Inc.
Retention in Care, Hiv
A Mobile Phone SMS Intervention to Increase Retention in HIV Care Among HIV-Positive MSM in Peru (WELTEL PERU)
We will use a web-based system in order to deliver a text messaging-based intervention and assess the efficacy to increase retention in HIV care among HIV+ gay men in Peru.
- Trial name
- NCT05227417
- Testing
- SMS
- Where
- Peru
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
HIV I Infection, Tuberculosis
Evaluating the Safety and Immunogenicity of MTBVAC
The purpose of this study is to evaluate the safety and immunogenicity of MTBVAC in adolescents and adults living with and without HIV in South Africa
- Trial name
- HVTN605A5421 (NCT05947890)
- Testing
- MTBVAC, BCG
- Where
- 16 sites in South Africa
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
Malaria
Assessment of Safety and Immunogenicity of R21/Matrix-M™ in African Children Living With HIV
A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M™ in African children living with HIV
- Trial name
- NCT05385510
- Testing
- R21/Matrix-M™
- Where
- Uganda
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV -1 Infection
Safety Study of MucoCept-CVN
MucoCept-CVN uses a Lactobacillus strain native to the human vagina that is modified into a live biotherapeutic product (LBP) that continuously expresses a potent anti-HIV drug.
- Trial name
- NCT07181486
- Testing
- Live Biotherapeutic Product L. jensenii 1153-1666
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Craig Cohen, MD, MPH
HIV Infections, Sexually Transmitted Diseases
MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania
The MEMA kwa Vijana Project is a community randomised trial which aims to assess the impact of a targeted intervention on adolescent sexual and reproductive health in Mwanza Region, Tanzania.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Pregnancy, Sexual Behavior
- Trial name
- NCT00248469
- Testing
- In-school Sexual Health Education, Youth-friendly health services, Youth condom promotion & distribution
- Where
- Tanzania
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
Safety and Immune Response to a Clade C DNA HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C DNA vaccine and to an MF59-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN111 (NCT02997969)
- Testing
- DNA-HIV-PT123 vaccine, Protein/MF59 vaccine
- Where
- 5 sites in South Africa, Tanzania and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus Infection, Sexually Transmitted Diseases
Men Together Making a Difference: Reducing HIV/STD Risk Behavior Among South African Men
Sub-Saharan Africa has about 10% of the world's population, but was home to more than 60% of all people living with HIV in 2003.
- Trial name
- NCT01490359
- Testing
- Men Making a Difference HIV/STD Risk Reduction Intervention, Health Promotion Control
- Volunteers
- 1,181 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hepatitis C, Drug Users
The Impact on Linkage-to-care of an Alternative Hepatitis C Screening Method in PWID
Screening, diagnosis and treatment of HCV in PWID, should be part of a harm reduction strategy. Treatment of HCV infected PWID should be delivered in a multidisciplinary care setting with services to reduce the risk of…
- Conditions
- Hepatitis C, Drug Users, Harm Reduction, HIV
- Trial name
- NCT02971488
- Testing
- Screening for HCV in PWID and Linkage-To-Care
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Leonor
Osteoporosis, Fractures
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups.
- Conditions
- Osteoporosis, Fractures, HIV Infection
- Trial name
- Probono1 (NCT01669954)
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- King's College London
Neurocysticercosis, HIV/AIDS
The Burden of (Neuro)Cysticercosis Among People Living With HIV in Rural Tanzania
This study aims to compare the burden of neurocysticercosis among people living with HIV to people not infected with HIV.
- Trial name
- CYSTINET_Tz (NCT03851419)
- Testing
- Diagnosis of (Neuro)cysticercosis
- Where
- Tanzania
- Volunteers
- 2,584 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Death, HIV Infection
Community-based Evaluation of a Pilot PMTCT Project in Kafue District
In this study, the investigators will assess the population effectiveness of using routine HAART as a PMTCT strategy, through a community-based survey.
- Trial name
- NCT00753428
- Testing
- Community-based Survey
- Where
- Zambia
- Volunteers
- 4,129 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Depression
Community Home-based Care Intervention and Its Health Outcome in HIV-positive People
An intervention study was designed to examine the impact of impact of community home-based care intervention on mental health and treatment outcome in HIV-positive people.
- Conditions
- Human Immunodeficiency Virus, Depression, Stress, Anxiety
- Trial name
- HIV (NCT03505866)
- Testing
- Community home-based care intervention
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Integrated Development Foundation Nepal
HIV Infections
A Comparison of Different Community Models of ART Delivery Amongst Stable HIV+ Patients in Two Urban Settings in Zambia
The purpose of this study is to compare the virological and clinical outcomes of patients participating in community models of ART delivery to the standard of care in an urban setting in Zambia.
- Trial name
- NCT03025165
- Testing
- Community Adherence Clubs, Home-Based ART Delivery, Standard of Care
- Where
- Zambia
- Volunteers
- 2,526 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
HIV Health Literacy
Facilitating HIV/AIDS and HIV Testing Literacy for Emergency Department Patients
The Centers for Disease Control and Prevention (CDC) recommends that all patients should receive information about HIV/AIDS and HIV testing orally or in writing at every HIV testing encounter.
- Trial name
- NCT02284451
- Testing
- Video or Pictorial Brochure
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Hiv, Adolescent Behavior
A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM
This pragmatic trial of an HIV prevention program focuses on HIV risk-reduction in men who have sex with men (MSM) ages 13-18. The design is a three-tiered, internet-based HIV prevention intervention series that uses a sequential…
- Conditions
- Hiv, Adolescent Behavior, Sex, Safe
- Trial name
- SMART (NCT03511131)
- Testing
- Queer Sex Ed, Keep It Up, Keep It Up-Control
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Northwestern University
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