Clinical trials: Infants Cardiac Surgery
Impaired Oxygen Delivery, Congenital Heart Disease
Restrictive Versus Liberal Transfusion Protocol in Infants Undergoing Cardiac Surgery
In neonates and infants </= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (RBC) transfusion strategy will be as effective as, and possibly superior to, a liberal RBC strategy.
- Trial name
- NCT01484886
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Cardiac Surgery
Effect of Intensive Insulin Therapy on Clinical Prognosis of Infants Undergoing Cardiac Surgery
The investigators sought to determine whether intensive insulin therapy can improve prognosis of infants undergoing cardiac surgery.
- Trial name
- NCT01398722
- Testing
- Intensive insulin therapy, Conventional insulin therapy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Xijing Hospital
Congenital Heart Disease in Children, Post-cardiac Surgery
To Assess the Efficacy of Early Administration of Energy Enriched and Protein Enriched Formula in Post Cardiac Repair Infants: a Randomized Controlled Trial, Comparative Study
Congenital heart disease (CHD) is a public health problem, A substantial percentage of infants and toddlers with CHD undergo cardiopulmonary bypass surgery.
- Conditions
- Congenital Heart Disease in Children, Post-cardiac Surgery, Malnutrition, Infant
- Trial name
- NCT05826769
- Testing
- Energy- Protein Enriched Nutritional Formula
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Congenital Heart Disease
Nitrogen Balance in Infants After Post Cardiothoracic Surgery
The objective is to the amount of protein infants require after cardiopulmonary bypass surgery.
- Trial name
- NCT01368705
- Testing
- Standard protein delivery, Intervention 1 (2.2g/kg/day), Intervention 2 (3.0 g/kg/day)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Acute Kidney Injury
Acute Kidney Injury in Children Operated for Congenital Heart Disease
The purpose of this study was to investigate if repeated inflation of a blood pressure cuff applied around one leg causing mild ischemia ("remote ischemic preconditioning") could protect children operated for congenital heart…
- Trial name
- NCT01316497
- Testing
- Remote ischemic preconditioning (RIPC), Control
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- University of Aarhus
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Adrenal Cortex Diseases, Infant Morbidity
Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery
Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone results in similar drug levels for all patients and to characterize the relationship between these drug levels and the innate stress…
- Trial name
- NCT01839812
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Anemia
Iron Prophylaxis for Anemia in Infants With Cyanotic Congenital Heart Disease
Anemia is a common disorder in infants with one working chamber of the heart that pumps blood. Anemia is when the level of healthy blood cells becomes too low.
- Trial name
- NCT00459225
- Testing
- Iron (ferrous sulfate)
- Where
- United States
- Sponsor
- Emory University
Prone posıtıon
Extruded the effectıveness of Prone posıtıon ın ınfants evaluatıon
The aim of this study was to determine the effect of prone position on vital signs, arterial blood gases and blood values in 0-1 year old infants extubated after congenital heart surgery.
- Trial name
- NCT06493058
- Testing
- Prone positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in Infants and Toddlers Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered infants…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06861998
- Testing
- Message-based bedtime routine, sleep hygiene education
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Yan Fuxia
Infants or Children Undergoing Open Heart Surgery
The Influence of Passive Leg Elevation on the Cross-sectional Area of the Internal Jugular Vein in Infants or Young Children Undergoing Open Heart Surgery
The trendelenburg position is usually applied to increase the cross-sectional area of the IJV. However, trendelenburg position requires a tilt table to place the head in the down position.
- Trial name
- NCT01401920
- Testing
- leg elevation, Trendelenburg position, Trendelenburg position + passive leg elevation
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Cardiac Event
Pharmacokinetics of Post Operative Cefuroxime in Infants Undergoing Cardiac Surgery
To evaluate plasma concentrations of Cefuroxime in this patient population To determine if certain pathophysiological and/or iatrogenic conditions alter the pharmacokinetics in this patient group.
- Trial name
- PHOXEY (NCT02850250)
- Testing
- Cefuroxime
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Congenital Heart Disease
Post-Op Massage in Infants With Congenital Heart Disease
The primary aims of the proposed study are to pilot test the effectiveness of daily massage on pain and clinical outcomes in infants who have undergone cardiothoracic surgery.
- Trial name
- NCT04416230
- Testing
- massage, quiet time
- Volunteers
- 65 people
- Sponsor
- Ohio State University
Cyanotic Congenital Heart Disease
Preventing Brain Injury in Infants With Congenital Heart Disease
Newborn babies with congenital heart disease often require surgery in the first month of life. The risks of brain damage from congenital heart disease and from the various corrective surgeries are high because of poor levels of…
- Trial name
- NCT01426542
- Testing
- Topiramate, No medication, but routine heart surgery
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Davis
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
Coarctation of Aorta
Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
- Trial name
- NCT02835703
- Testing
- Surgical repair of coarctation of aorta
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Transfusion
Use of Cell Salvage Post-operatively in Infants to Decrease Use of Allogeneic Blood Product Transfusions
Transfusion of washed intra-operative cell salvage post-operatively in the PCICU can be performed safely without increased risk of bleeding or release of inflammatory mediators.
- Trial name
- cell salvage (NCT01211366)
- Testing
- Cell Saver RBCs, Conventional volume infusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Rochester
Congenital Heart Disease
HFNC vs NIPPV Following Extubation
This study has the goal to determine the best method of respiratory support following extubation after cardiac surgery (CS). After cardiac surgery for Congenital Heart Disease (CHD), patients remain intubated until the cardiac…
- Trial name
- NCT05869825
- Testing
- High Flow Nasal Canula following extubation, Non-Invasive Positive Pressure Ventilation following extubation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia
Infants and children undergoing cardiac surgery require mechanical support for circulation called cardiopulmonary bypass. The artificial pump ensures that blood flow to the body is maintained during surgical procedure on the…
- Trial name
- I-TRICC (NCT02222532)
- Testing
- Tetronine
- Where
- Indonesia
- Volunteers
- 224 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia