Clinical trials: Infant Death
MLD, Krabbe Disease
Longitudinal Study of Neurodegenerative Disorders
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the…
- Conditions
- MLD, Krabbe Disease, ALD, MPS I
- Trial name
- NCT03333200
- Testing
- Palliative Care, Hematopoetic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pittsburgh
Infant, Newborn, Infant, Low Birth Weight
Inflammatory Cytokines Associated With Perinatal Brain Injury
This observational study assessed whether measurements of certain pro-inflammatory and anti-inflammatory cytokines in the blood (either singly or in combination) at birth and/or up to day of life 21 can predict cerebral palsy at…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Cytokines (NCT01035697)
- Where
- 18 sites in United States
- Volunteers
- 1,067 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Health Behavior
Reduce African-American Infant Mortality
The overall purpose of this randomized trial is to develop and evaluate a systematic approach to improve African-American parental behaviors specifically with regards to the infant sleep environment.
- Trial name
- SIDS (NCT01361880)
- Testing
- Reduce Infant Mortality
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Reproductive, Maternal, Newborn, and Child Health, Integrated, Community-Health Systems
Implementing an Integrated RMNCH Intervention by Community Health Workers in Achham and Dolakha: National Pilot
The investigators will conduct a cluster-controlled, stepped wedge implementation science trial of a bundled reproductive, maternal, neonatal, and child healthcare (RMNCH) delivery intervention within an approximate population of…
- Trial name
- NCT03371186
- Testing
- Community Health Worker, Continuous Surveillance, CB-Integrated Management of Newborn and Childhood Illness
- Where
- 2 sites in Nepal
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Possible
Maternal Death, Infant Death
Effects of a Health Workforce Capacity Building and Quality Improvement Intervention in Kinshasa
The aim of the study is to evaluate a health workforce capacity building and quality improvement intervention focused on integrated day-of-birth and post-pregnancy care at 16 hospitals in Kinshasa, Democratic Republic of Congo.
- Conditions
- Maternal Death, Infant Death, Stillbirth
- Trial name
- NCT03363308
- Testing
- training for health care workers supplmented by QI teams
- Where
- Democratic Republic of the Congo
- Volunteers
- 250 people
- Sponsor
- Jhpiego
Preterm Birth, Preterm Labor
Impact of the PREEMI Package on Neonatal Mortality
The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum…
- Conditions
- Preterm Birth, Preterm Labor, Neonatal Death
- Trial name
- PREEMI (NCT03923023)
- Where
- 2 sites in Zambia
- Volunteers
- 11,195 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Infant Mortality, Morbidity
Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine
In the present study the investigators wish to address the effects of different doses of vitamin A supplementation in low and normal birth weight infants.
- Trial name
- NCT00168610
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 7,600 people
- Sponsor
- Bandim Health Project
Vitamin D Deficiency, Pre Eclampsia
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Vitamin D deficiency is wide spread in South Asian population and is contributing to burden of disease in this region including Pakistan.
- Conditions
- Vitamin D Deficiency, Pre Eclampsia, Stillbirths, Low Birth Weight
- Trial name
- NCT01229189
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 460 people
- Sponsor
- Aga Khan University
Sudden Infant Death
Investigation of the Genetic Diseases in Infants With Unknown Cause of Death
Sudden infant death syndrome (SIDS) is a disease of an infant under one year of age, whose sudden death occurred unexpectedly, which the cause of death cannot be determined despite macro-autopsy, and toxicological, pathological…
- Trial name
- SIDS (NCT06060249)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Bronchopulmonary Dysplasia
Respiratory Management of Preterm Infants and Bronchopulmonary Dysplasia
This observational study evaluates the impact of respiratory management modifications implemented in our institution on the intubation rates and the death or Bronchopulmonary Dysplasia (BPD) outcome.
- Trial name
- NCT03411018
- Testing
- Mechanical ventilation exposure
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Manuel Sanchez Luna
Preterm, Infant Death
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks…
- Trial name
- CORDMILK-PT (NCT06240715)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 800 people
- Sponsor
- Nemours Children's Clinic
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Stillbirth, Neonatal Death
Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda
A novel handheld Doppler has been developed which is rugged and is powered only by a hand crank. This study aims to test the use of this Doppler versus the Pinard horn to monitor the fetal heart rate in labour in a hospital…
- Trial name
- NCT02273037
- Testing
- Fetal heart rate Doppler, Partograph
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Palliative Medicine, Pediatric ALL
Paediatric Palliative Care Pain Management in the Community
To describe the the barriers and facilitators experienced by carers and healthcare professionals when managing medicines for pain relief for infants, children, and young people approaching the end of life in out of hospital…
- Trial name
- PARAMOUNT (NCT04519632)
- Testing
- Qualitative study
- Where
- United Kingdom
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Bronchopulmonary Dysplasia, Death
Systemic Management in Extremely Preterm and Extremely Low Birth Weight Infants
to estimate incidences of major complications, such as bronchopulmonary dysplasia, death, and delivery room resuscitation among extremely preterm and extremely low birth weight infants in Northern China
- Trial name
- NCT06082414
- Testing
- no interventions
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Peking University
Pregnancy Loss, Infant Death
In-utero Death and Birth Mortality in Reunion Island
Infant mortality is still relevant despite the improvement and the accessibility of hospital care. Premature birth are two fold higher than in metropolitan France.
- Trial name
- RAMIR (NCT03354832)
- Testing
- Foetal death, New-born death, Birth control for foetal death
- Where
- Reunion
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Child Mortality
Infant Mortality Reduction by the Mass Administration of Azithromycin
This trial will investigate the supplementation of azithromycin distribution to the "Child Health Days" platform in Burkina Faso for child mortality reduction.
- Trial name
- MIRAMA (NCT04716712)
- Testing
- Azithromycin
- Where
- 3 sites in United States, Burkina Faso
- Volunteers
- 694,400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fetal Membranes, Premature Rupture
Perinatal Outcome After Premature Rupture of Membranes
Premature rupture of membranes is an important cause of neonatal morbidity and mortality, mainly because of the complications associated with this pathology (oligohydramnios, cord compression or prolapse, infection).
- Trial name
- NCT01538030
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Birth Asphyxia, Premature Birth
Oxygen Toxicity in the Resuscitation in Extremely Premature Infants
The investigators hypothesize that using low oxygen concentrations during resuscitation of extremely premature infants will avoid oxidative stress derived damage and improve outcome.
- Trial name
- OXTOX (NCT00494702)
- Testing
- Resuscitation
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Fundacion Para La Investigacion Hospital La Fe
Sudden Infant Death
Generations in Families Talking Safe Sleep
Teen mothers present a unique set of challenges in reducing the risk for sleep-related infant mortality, in part because they may not be the sole decision-maker for an infant's sleep environment and position and they make seek…
- Trial name
- GIFTSS (NCT03186469)
- Testing
- Safety Baby shower, Standard of Care
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute