Clinical trials: Induction of Anesthesia
Induction and Maintenance of General Anesthesia
A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients
This is a multi-center, randomized, open-label, positive-controlled (propofol) phase II clinical trial. The study plans to enroll approximately 46 eligible subjects.
- Trial name
- NCT04048811
- Testing
- HSK3486, Propofol, Propofol HSK3486
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Prostate Tumor
Remimazolam Versus Propofol for General Anesthesia Induction in Patients on Renin-angiotensin System Blockers Undergoing Robot-assisted Laparoscopic Prostatectomy
The investigators conduct a random assignment into either the remimazolam group or the propofol group. Depending on the group assignment, either remimazolam (0.2 mg/kg) or propofol (1.0 mg/kg) is administered.
- Trial name
- NCT06093971
- Testing
- remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Yonsei University
Postoperative Delirium
Association Between Burst Suppression During Anesthetic Induction With Postoperative Delirium in Cardiac Surgery
The population over 65 years of age will be increasingly exposed to surgical procedures that require general anesthesia. Postoperative delirium is one of the main causes of preventable postoperative morbidity in the elderly…
- Trial name
- NCT04713644
- Testing
- Standardized Propofol Administration
- Where
- Chile
- Volunteers
- 78 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Hypotension
Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia
Hypotension is frequently encountered after induction of general anesthesia. It can be pronounced in elderly patients and can require administration of vasopressor agents including ephedrine and phenylephrine.
- Trial name
- Fentanyl (NCT02489019)
- Testing
- Sodium chloride, Fentanyl
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Loyola University
Hemodynamics, Postoperative Recovery
Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery
To study the Effect of Ciprofol Infusion for Induction and Maintenance of anesthesia on Hemodynamics and Postoperative Recovery in Patients Undergoing Thoracoscopic Lobectomy:a randomized, controlled trial.
- Conditions
- Hemodynamics, Postoperative Recovery, Anesthesia
- Trial name
- NCT05664386
- Testing
- propofol, ciprofol
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xiumei Song
Obesity
Effect of Inverse Ratio Ventilation During Induction of General Anesthesia on Safe Apnea Time in Obese Patients
The purpose of this study is to investigate the clinical application value of inverse ratio ventilation in obese patients during induction of general anesthesia by studying the effect of inverse ratio ventilation on the safe…
- Trial name
- NCT04627883
- Testing
- Inspiratory-to-expiratory (I : E) ratio of 1:2, Inspiratory-to-expiratory (I : E) ratio of 2:1
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia, General
Reduction of Rocuronium-induced Injection Pain With Aspiration of Blood
The goal of this clinical trial is to learn about reduction of rocuronium injection pain in participants receiving general anesthesia.
- Trial name
- NCT06150001
- Testing
- rocuronium-normal-saline mixture, rocuronium-lidocaine mixture, rocuronium-blood mixture
- Where
- Taiwan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
General Anesthesia Induction for Elective Surgery, Sono Guided Catheterization
Sonographic Safety Margins of Subclavian Vein: Effect of View and Arm Position
The purpose of this observational study is to evaluate and compare the anatomical safety margins of the subclavian vein using ultrasound.
- Trial name
- NCT07556770
- Testing
- Non-invasive sonographic observation
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Asan Medical Center
Induction of General Anesthesia
Propofol Versus Sevoflurane for Induction of GA in Infants
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
- Trial name
- NCT05105022
- Testing
- Propofol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Hypotension
Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients
Arterial hypotension is a frequent complication of general anesthesia and a significant contributor to postoperative complications.
- Trial name
- NORAFLOW (NCT06350929)
- Testing
- Cardiac output monitoring by the Starling™ SV Sebac®
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Anesthesia Emergence Delirium
Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics
Emergence agitation (EA) is a post-operative behavioral disturbance was first reported in early 1960s. EA is a term used to describe non purposeful restlessness and agitation, thrashing, crying or moaning, disorientation and…
- Trial name
- NCT06077539
- Testing
- Dexmedetomidine, Ketamine, Magnesium
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Anesthesia
Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance
During this study, the pharmacodynamic interactions between sevoflurane and remifentanil will be studied.
- Trial name
- NCT00522587
- Testing
- Fixed sevoflurane dose 1, Fixed sevoflurane dose 2, Fixed sevoflurane dose 3
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Anesthesia Recovery
"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"
Prospective Randomized non inferiority Trial involving adult patients undergoing elective surgery under general anesthesia.56 Patients will be enrolled in 2 groups : full dose sugammadex vs half dose sugammadex for reversal of…
- Trial name
- NCT02375217
- Testing
- Sugammadex, Neostigmine, glycopyrrolate
- Where
- Lebanon
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Rapid Sequence Induction
Classic and Modified Rapid Sequence Induction for Prevention of Gastric Content Regurgitation
Induction of anesthesia induces a loss of protective upper airway reflexes and is associated with gastric content regurgitation.
- Trial name
- NCT04312425
- Testing
- Modified rapid sequence induction, Classic rapid sequence induction
- Where
- China
- Volunteers
- 8,601 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ventilation, Intubation Complication
Quality of Ventilation With Facial Versus Nasal Mask vs Nasal Mask Anesthesia in Children 3 to 12 Years Old
In this single-blind clinical trial study, 70children who are candidates for lower abdominal elective surgery under general anesthesia presented at Imam Hossein Hospital in Isfahan will be included in the study and will be…
- Conditions
- Ventilation, Intubation Complication, Intubation; Difficult or Failed
- Trial name
- NCT05018468
- Testing
- Ventilation
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Transcatheter Aortic Valve Replacement (TAVR), Hemodynamic Stability
Frequency of Electrical Acupoint Stimulation on Hypotension in TAVR Patients
Within 30 minutes before anesthesia, acupoint electrical stimulation at different frequencies were applied at Neiguan, Jian Shi, and Baihui.
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Hemodynamic Stability, Anesthesia Induction, Electro-acupuncture
- Trial name
- FRESH-T (NCT07365345)
- Testing
- electrical acupoint stimulation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Air Force Military Medical University, China
Postoperative Complications
Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)
Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia.
- Trial name
- COIN (NCT05728645)
- Testing
- Hydroxyethyl Starch 130/0.4 and Electrolyte injection of 5ml/kg, Multiple Electrolytes injection of 5 ml/kg
- Where
- China
- Volunteers
- 2,022 people
- Sponsor
- Xijing Hospital
Perfusion Index
PERFUSION INDEX, PRONE ,SUPİNE AND SITTING POSITION
The aim was to investigate the effect of anesthesia management on perfusion index changes in obese patients and different anesthesia positions.
- Trial name
- NCT06742619
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Amasya University
Anesthesia Induced Hypothermia, Inadvertent Perioperative Hypothermia
Study to Evaluate Safety and Efficacy of Blanket Used to Prevent Anesthesia Induced Hypothermia
The investigation was designed as an Open-Label, Multicenter, Randomised, Controlled Investigation to Evaluate the Efficacy and Safety of the BARRIER® EasyWarm Active Self-Warming Blanket Used for Continuous Active Warming to…
- Trial name
- NCT01900067
- Testing
- BARRIER® EasyWarm Active Self-Warming Blanket
- Volunteers
- 271 people
- Sponsor
- Molnlycke Health Care AB
Hypotension, Anesthesia
Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Background: Spinal anesthesia (SA) is preferred over general anesthesia in Cesarean section (CS) due to its better safety profile but SA induced hypotension remains a big challenge for the clinical Anesthetist.
- Trial name
- NCT05348980
- Testing
- Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI