Clinical trials: Induced Labor
Labor, Induced
Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction
This study evaluates the efficacy and safety of the administration of oral misoprostol versus vaginal dinoprostone and vaginal misoprostol for cervical ripening and labor induction.
- Trial name
- NCT02902653
- Testing
- Oral misoprostol, Vaginal misoprostol, Vaginal dinoprostone
- Where
- Spain
- Volunteers
- 372 people
- Sponsor
- Oihane Lapuente Ocamica
Induction of Labor
Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon
The purpose of this study is to specifically investigate the efficacy of an alternative pharmacologic cervical ripening agent, misoprostol, versus the standard oxytocin, as an adjunct to Foley balloon for induction of the…
- Trial name
- NCT01139801
- Testing
- Oxytocin, Misoprostol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aultman Health Foundation
Antepartum Hemorrhage, Postpartum Hemorrhage
Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan
The Maternal Neonatal and Child health indicators in District Dadu of Pakistan portrays a dismal pictures and after the floods of 2010-2011 the health infrastructure of this district was badly affected.
- Conditions
- Antepartum Hemorrhage, Postpartum Hemorrhage, Anemia, Eclampsia
- Trial name
- SRC (NCT02797353)
- Testing
- Maternal Neonatal and Child Health Interventions
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Infant,Premature, Bronchopulmonary Dysplasia
L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects up to 35% of very low birth weight infants (VLBW < 1500 g).
- Conditions
- Infant,Premature, Bronchopulmonary Dysplasia, Pulmonary Hypertension
- Trial name
- NCT03542812
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Induction of Childbirth
3-hour Versus 12-hour Double-balloon Catheter for Labor Induction
This study aims to demonstrate that a 3-hour ultra-short cervical ripening protocol using a double-balloon catheter significantly reduces the induction-to-birth interval by at least 6 hours compared to the standard 12-hour…
- Trial name
- BAL3H (NCT07492186)
- Testing
- Cook® double-balloon catheter
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Centre Hospitalier de PAU
Bronchopulmonary Dysplasia
Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia
This is a long term follow-up study of the open label, single-center, phase I clinical trial to evaluate the safety of Pneumostem® in premature infants with BPD.
- Trial name
- NCT01632475
- Testing
- Pneumostem®
- Where
- 2 sites in South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Labor Induction
Oral Misoprostol for Outpatient Induction of Labor
An increasing proportion of pregnant women have their labors induced due to changing guidelines. In correlation with this increase, the population of the induced women has changed toward more women with a low-risk pregnancy.
- Trial name
- NCT04596397
- Testing
- Inpatient setting, Outpatient setting
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sorlandet Hospital HF
Preeclampsia
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery
Preeclampsia is a syndrome that occurs in approximately 3% to 8% of pregnancies and is associated with considerable maternal and neonatal morbidity and mortality.
- Trial name
- RAAPID-II (NCT01404910)
- Testing
- Apheresis using Liposorber LA-15 System
- Where
- 3 sites in United States, Germany
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Induction of Labor Affected Fetus / Newborn
Accuracy of Different Scoring Systems for Predicting Successful Induction of Labor
Induction of labour (IOL) nowadays is a common procedure in obstetric practice. Presently, IOL is done for 20% of pregnancies for various maternal and fetal indications and nearly 20% of labour inductions end up in caesarean…
- Trial name
- NCT04325256
- Testing
- Manipal ultrasound scoring system, Levine scoring system
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Premature Newborn
Conditions of Realization of the Echocardiography in Newborns
Experimental nociceptive stimulation of the fetus and neonate induces pulmonary artery vasoconstriction. The investigators assessed whether echocardiography for Ductus arteriosus screening may generate this hemodynamic response…
- Trial name
- NCT02893956
- Testing
- echocardiography with postural support, echocardiography with standard condition (usual)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Labour Induction
Impact of Early Versus Late Amniotomy on Labour Induction in Nulliparous Women After Vaginal Misoprostol
Investigation the effect of timing of amniotomy (early versus delayed) after vaginal misoprostol in induced labor. Condition: induction of labour intervention: eary versus late amniotomy on labour induction after vaginal…
- Trial name
- RCT (NCT04514770)
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Medical Induction of Labor Affecting Newborn
Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management
The study is intended to compare expectant management and on presentation labor induction in women with premature rupture of membranes. The means of labor induction and cervical ripening are either oxytocin or dinoprostone.
- Trial name
- NCT02825641
- Testing
- Oxytocin, Dinoprostone
- Where
- Israel
- Volunteers
- 458 people
- Sponsor
- Rambam Health Care Campus
Preeclampsia, Gestational Diabetes
Exercise and Pregnancy: Randomized Clinical Trial
The effects of physical exercise on pregnancy remain to be elucidated. A randomized controlled trial will be conducted to study the impact of exercise on maternal and perinatal outcomes.
- Trial name
- NCT00641550
- Testing
- Physical exercise
- Where
- 2 sites in Brazil
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual da Paraiba
Preterm Pregnancy, Labor Induction
Preterm Induction of Labor Timing of Amniotomy: A Randomized Controlled Trial
Artificial rupture of membranes (amniotomy) is a commonly used technique to safely induce and augment labor. It has been shown to reduce the duration of spontaneous and induced labor in term patients (≥37 weeks' gestation).
- Trial name
- PITA (NCT03504670)
- Testing
- Early Amniotomy, Late Amniotomy
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Alabama at Birmingham
Pre-Eclampsia
L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia
This study is intended to assess the efficacy of L-arginine supplementation with antioxidant vitamins delivered in a medical food in reducing the incidence of preeclampsia in a high-risk population.
- Trial name
- L-Arg (NCT00469846)
- Testing
- L-arginine supplementation in a medical food, Vitamin C and E supplementation in a medical food
- Where
- 2 sites in United States, Mexico
- Volunteers
- 585 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Induction of Labor Affected Fetus / Newborn
The Success of Labor Induction Based on a Modified BISHOP Score.
Pregnant women at term will be divided randomly into 3 groups: 1. Gynecological evaluation based on classic BISHOP score. 2. Gynecological evaluation based on a modified BISHOP score. 3.
- Trial name
- NCT04220320
- Testing
- Vaginal examination., Transvaginal sonography.
- Where
- Israel
- Volunteers
- 758 people
- Sponsor
- Rambam Health Care Campus
Anesthesia, Epidural, Hypotension
Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
The purpose of this pilot trial is to examine the feasibility and ease of use of monitoring by ClearSight in laboring and delivering patients with the intent to compare time-to-treatment of hypotension between conventionally…
- Trial name
- NCT05906368
- Testing
- ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Gestational Diabetes Mellitus, Preeclampsia
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is a heterogeneous condition, characterised by metabolic disturbances, insulin resistance and hyperandrogenism.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Preterm Birth, Polycystic Ovary Syndrome
- Trial name
- MYPP (NCT05524259)
- Testing
- Myo-inositol and routinely recommended folic acid, Routinely recommended folic acid
- Where
- Netherlands
- Volunteers
- 464 people
- Sponsor
- Erasmus Medical Center
Apnea, Infant, Premature
Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants.
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is common.
- Conditions
- Apnea, Infant, Premature, Bronchopulmonary Dysplasia
- Trial name
- NCT00188968
- Testing
- Nasal Continuous Positive Airway Pressure, Synchronized Nasal Positive Pressure Ventilation
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic…
- Conditions
- Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia, Intrauterine Growth Restriction, Aspirin
- Trial name
- CHASAP (NCT04356326)
- Testing
- Aspirin 150 mg
- Where
- 20 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil