Clinical trials: Incomplete Spinal Cord Injury
Spinal Cord Injury
Can Vibration Stimulation of the Foot Sole Activate Leg Muscles?
Participants will be asked to complete three different tests (standing, stepping and assisted walking) and will experience three different experimental conditions during each test.
- Trial name
- NCT02043106
- Testing
- plantar vibration
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injuries, Incomplete Spinal Cord Injury
A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES
Neuromuscular electrical stimulation (NMES) remains as one of the effective rehabilitation modalities for addressing recovery of neuromuscular function after a spinal cord injury (SCI).
- Trial name
- NCT05243576
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Gait Disorders, Neurologic, Gait Disorder, Sensorimotor
Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury
Adaptive gait assessements will be evaluated as a potential new marker for tracking locomotor recovery throughout rehabilitation of spinal cord injury subjects.
- Trial name
- NCT03343132
- Testing
- Standard locomotor therapy
- Where
- Switzerland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Incomplete Spinal Cord Injury
The Effect of Acute Intermittent Hypoxia on Motor Learning
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.
- Trial name
- NCT05341466
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Spinal Cord Injuries
Sensorimotor Integration Underlying Balance Control in Individuals With Incomplete Spinal Cord Injury
The objectives of the study are to evaluate a 4-week mixed training paradigm consisting of explosive strength training and balance perturbation training efficacy on balance control during standing and locomotion, and to…
- Trial name
- NCT05200091
- Testing
- Combined explosive strength and specific balance training group
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injury
Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury
The purpose of this study is to determine whether exercising (walking) at different intensities increases levels of factors in the blood and saliva that are known to impact neuroplasticity (how the connections in the spinal cord…
- Trial name
- NCT01538693
- Testing
- escitalopram oxalate, Cyproheptadine, sugar pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- T. George Hornby
Incomplete Spinal Cord Injury, Brown Sequard Syndrome
Walking Adaptability Post-Spinal Cord Injury
The purpose of this study is: (1) to establish assessment techniques (in our laboratory) to identify the functional integrity of long spinal tracts associated with adaptive walking recovery post-spinal cord injury and (2) to…
- Trial name
- NCT01851629
- Testing
- Locomotor Training, Cross-Sectional Testing (No Intervention)
- Where
- 4 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Florida
Complete Spinal Cord Injury, Incomplete Spinal Cord Injury
Algorithmic-Based Evaluation and Treatment Approach for Robotic Gait Training
The purpose of this study is to develop an algorithmic-based evaluation and treatment approach for wearable robotic exoskeleton (WRE) gait training for patients with neurological conditions.
- Conditions
- Complete Spinal Cord Injury, Incomplete Spinal Cord Injury, Acquired Brain Injury, Multiple Sclerosis
- Trial name
- NCT03057652
- Testing
- ReWalk, EKSO, REX
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injury
Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in…
- Trial name
- NCT01539109
- Testing
- Rehabilitation, Noninvasive brain stimulation: tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Spinal Cord Injuries, Paraplegia, Spinal
Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
The central objective of this study is to validate new algorithms that coordinate between functional electrical stimulation (FES) and the exoskeleton during sitting-to-standing, walking, and standing-to-sitting movements.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT04453943
- Testing
- Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level
Neuromodulation With Spinal Stimulation Methods
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT06272279
- Testing
- spinal stimulation-DCS, spinal stimulation-EPS
- Where
- 2 sites in Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Spinal Cord Injuries (SCI), Spinal Cord Injury
mSCI: Mobile Health App for Veterans With SCI and Caregivers
Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation.
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Cord Injuries (Complete and Incomplete), Family Caregivers
- Trial name
- NCT07269977
- Testing
- iMHERE 2.0. A mobile health App designed to support veterans with SCI manage their self care, and their caregivers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied
Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
- Trial name
- NCT06906536
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Psychological Well-Being, Spinal Cord Injuries
Self-Management Program for AIS D SCI
About 25-51% of adults with acquired spinal cord injury (SCI) have "AIS D" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and…
- Trial name
- SCISM-D (NCT05800717)
- Testing
- SCI Self-Management for AIS D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Incomplete Spinal Cord Injury, Transverse Myelitis
Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance
Robotic therapies aim to improve limb function in individuals with neurological injury. Modulation of robotic assistance in many of these therapies is achieved by measuring the extant volitional strength of limb muscles.
- Trial name
- NCT05249595
- Testing
- Surface electromypgraphy-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices, Surface electromypgraphy and ultrasound imaging-based interface to predict human ankle joint motion intent and use in ankle assistive devices
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Spinal Cord Injuries
Exoskeleton Training on Balance Control and Turning in Ambulation in Individuals With Incomplete Spinal Cord Injury
This study investigates the impact of exoskeleton training on individuals with incomplete spinal cord injury (iSCI). Investigators focus on assessing how the use of the exoskeleton influences balance control and turning during…
- Trial name
- iSCI (NCT06971510)
- Testing
- Exoskeleton Training, Conventional Physical Therapy
- Where
- 3 sites in China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Spinal Cord Injury
Effects of Lokomat Training on Dynamic Postural Stability in Incomplete Spinal Cord Injury
The study aims to evaluate the effects of robotic-assisted gait training (Lokomat) on dynamic postural stability in patients with incomplete spinal cord injury (SCI).
- Trial name
- NCT07621900
- Testing
- Robotic Rehabilitation, Control
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University