Clinical trials: In Vitro Fertilisation (IVF) Treatment
Infertility
Human Chorionic Gonadotropin Supplementation Prior to In-vitro Fertilization Treatment in Poor Responders
In an era of delayed fertility plans, there is increasing need for fertility treatment in older women with poor response. Human chorionic gonadotropin (hCG) supplementation prior to treatment, as a thecal stimulant, may improve…
- Trial name
- NCT01205009
- Testing
- Ovitrelle
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
PCOS GnRH Antagonist and GnRH Agonist IVF/ICSI Cycles
In Vitro Fertilization Outcomes of Two Treatment Protocols in Women With Polycystic Ovary Syndrome
Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
- Trial name
- PCOS and ivf (NCT01354275)
- Testing
- To compare the IVF/ICSI outcomes of GnRH Antagonist cycle versus GnRH agonist cycle, GnRH Antagonist
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bulent Haydardedeoglu
Endometriosis, Infertility
The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis
The purpose of this study is to determine whether the administration of an analogue of gonadotropin-releasing hormone (GnRH) during the three months prior to the performing of an IVF may improve the response to ovarian…
- Trial name
- ENDOFIV (NCT01581359)
- Testing
- Triptorelin acetate
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Infertility
Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients
A prospective, randomized, controlled study to explore the efficacy and safety of using either corifollitropin alfa 150 mcg or daily recombinant follicle stimulation hormone (FSH) 300 international unit (IU) for the stimulation…
- Trial name
- NCT02466204
- Testing
- corifollitropin alfa, Follitropin Beta
- Where
- 2 sites in Vietnam
- Volunteers
- 400 people
- Sponsor
- Vietnam National University
Infertility
Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
This is a randomized, double-blind, single center clinical trial study to compare oocyte competence and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG)…
- Trial name
- NCT02310919
- Testing
- Low dose hCG plus FSH co-trigger, Standard dose of hCG
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Individualization of Ovarian Stimulation Using AMH Maximizes the Benefits and Minimizes Complications and Risks
The purpose oh the study is to determine the usefulness of anti-Mullerian hormone (AMH) to identify women at risk of excessive and poor response in controlled ovarian stimulation (COS) for in vitro fertilization (IVF), and the…
- Trial name
- NCT01887652
- Testing
- conventional ovarian stimulation, individualized ovarian stimulation
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Quality of Life, IVF
CALM IVF (Creating Affiliations, Learning, and Mindfulness for In Vitro Fertilization Patients)
The investigators have designed a psychoeducational group curriculum specifically for new in vitro fertilization (IVF) patients (both male and female) to improve their treatment knowledge, to allow them to engage more in their…
- Conditions
- Quality of Life, IVF, Patient Satisfaction, Patient Engagement
- Trial name
- NCT04048772
- Testing
- CALM IVF, Standard of Care
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Depression, Anxiety
E-health Cognitive Behavioral Therapy in Women Treated by in Vitro Fertilization (IVF)
Yearly, 15,000 Dutch in vitro fertilization (IVF) cycles are performed for subfertility with a pregnancy rate of 26%. A failed cycle has great emotional impact; 20-25% of the women has relevant forms of depression/anxiety even…
- Conditions
- Depression, Anxiety, Infertility
- Trial name
- NCT01283607
- Testing
- Digicoach
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- University Medical Center Nijmegen
Subfertility
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment
To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the…
- Trial name
- NCT02713854
- Testing
- endometrial biopsy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Infertility
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Intralipid can suppress natural killer cells that are known to be involve in repeated implantation failure and recurrent miscarriages.Intralipid is made of purified soybean oil, egg phospholipids, glycerol and water.
- Trial name
- NCT01916798
- Testing
- Intralipid infusion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs)
Effect of Immunomodulatory Treatment on IVF (in Vitro Fertilization) Outcomes in Patients With KIR AA Genotype
The aim of the study is to investigate the immune cause of recurrent implantation failure (RIF) and the role of immunomodulatory treatment in IVF (in vitro fertilization) patients that have a KIR AA genotype.
- Conditions
- Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs), KIR Alleles (KIR AA)
- Trial name
- NCT06264206
- Testing
- Killer-cell immunoglobulin-like receptors (KIRs) testing
- Where
- Romania
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Calla IVF Center
Subfertility
RCT on the Effect of Endometrial Injury on Ongoing Pregnancy Rate in Subfertile Women Undergoing IVF
Implantation failure remains one of the major factors limiting success in IVF treatment. It was postulated that the local injury to endometrium induces secretions of cytokines and growth factors such as leukemia inhibitory…
- Trial name
- NCT01977976
- Testing
- Endometrial aspiration by pipelle
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Fertilization in Vitro
The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.
In Zeynep Kamil Women and Children's Education and Research Hospital which is a tertiary referral hospital, the investigators perform microdose flare-up gonadotropin-releasing hormone (GNRH) analogue or GNRH antagonist protocol…
- Trial name
- NCT03527823
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sebnem Alanya Tosun
Infertility, Female, Polycystic Ovary Syndrome
Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
The aim of the study is to study the effect of an antioxidant food supplement associated with probiotics on the oocyte quality response, oxidative stress and microbiota function in an in vitro fertilization cycle in patients with…
- Trial name
- NCT04670393
- Testing
- FertyBiotic Woman Plus
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fertypharm
Infertility, Polycystic Ovarian Syndrome
IVF Versus Gonadotropin Therapy in Women With CC Resistant PCOS
The purpose of this study is to compare the efficacy of in vitro fertilization (IVF) versus gonadotropin therapy in infertile women having clomiphene citrate (CC) resistant polycystic ovarian syndrome (PCOS).
- Trial name
- NCT02458963
- Testing
- IVF, Gonadotropin
- Where
- 2 sites in Egypt
- Sponsor
- Mohamed Sayed Abdelhafez
Subclinical Hypothyroidism, Infertility
Levothyroxine Treatment and IVF Outcomes in Women With Subclinical Hypothyroidism: A Target Trial Emulation
Subclinical hypothyroidism (SCH) is defined by elevated thyroid-stimulating hormone (TSH) with normal free thyroxine (fT4) levels.
- Conditions
- Subclinical Hypothyroidism, Infertility, Assisted Reproductive Technology, In Vitro Fertilization (IVF)
- Trial name
- LESI (NCT07257250)
- Where
- 2 sites in Vietnam
- Volunteers
- 900 people
- Sponsor
- Mỹ Đức Hospital
Infertility
Predictive Value of AMH in IVF; a Prospective RCT
The primary aim of this trial is to compare two groups of women undergoing IVF (IVF=in vitro fertilisation ) treatment, to investigate if assessment of AMH (AMH=Anti-Müllerian hormone ), in addition to assessment of maternal age…
- Trial name
- AMH (NCT02013973)
- Testing
- AMH-analysis
- Where
- Sweden
- Volunteers
- 308 people
- Sponsor
- Ann Thurin Kjellberg
Infertility, Female, Luteinizing Hormone (LH)
Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment
This randomized controlled trial aims to evaluate whether supplementation with exogenous luteinizing hormone (LH) can improve embryo quality in patients undergoing in vitro fertilization (IVF) with a long gonadotropin-releasing…
- Trial name
- ELH-IVF (NCT07128394)
- Testing
- Recombinant Luteinizing Hormone (rLH), Recombinant Follicle-Stimulating Hormone (rFSH), Gonadotropin-Releasing Hormone Agonist (GnRH-a)
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Nanjing University
Pregnancy, In Vitro Fertilization
The Impact of Early Embryos Incubation on Pregnancy Rate in IVF
Frozen- thawed embryos obtained by IVF treatments are transferred to the uterus immediately following thawing or after incubation for additional 24-72 hours. The two methods are routine in IVF laboratories.
- Trial name
- IVF-2010 (NCT01287273)
- Where
- Israel
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Martha Dirnfeld
In Vitro Fertilization, Polycystic Ovary Syndrome
Comparative Study of Long-acting and Short Acting Triptorelin in PCOS Patients Who Underwent IVF/ICSI
To test whether long-acting Triptorelin on pituitary down-regulation can improve the clinical pregnancy rate and reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic…
- Trial name
- NCT02477566
- Testing
- Long-acting Triptorelin, Short-acting Triptorelin
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing University