Clinical trials: Implementation Strategies
HIV Infections
Implementation a Data-to-Care Strategy to Improve HIV Continuum Outcomes for Out of Care People Living With HIV (PLWH) in Ukraine
The goal of this clinical trial is to study the preliminary effectiveness of a data to care intervention versus standard of care for people living with HIV in Ukraine.
- Trial name
- NCT05821413
- Testing
- Data to care, Standard of Care
- Where
- Ukraine
- Volunteers
- 160 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type II Diabetes, Primary Health Care
INTEGRATE-D: A Pilot Test to Support Integration of Medical and Psychosocial Care for People With Type II Diabetes
In 2016, the American Diabetes Association (ADA) published its first-ever recommendations for integrating medical and psychosocial care for patients with Type II Diabetes Mellitus (DMII) and common mental and behavioral health…
- Conditions
- Type II Diabetes, Primary Health Care, Behavioral Health
- Trial name
- NCT04461405
- Testing
- INTEGRATE-D
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Concussion, Brain
Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department
Investigators will conduct a hybrid implementation-effectiveness evaluation of an educational intervention that supports communication with families post-concussion in the emergency department.
- Trial name
- NCT04112914
- Testing
- Post-concussion education for families
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Pre-exposure Prophylaxis, HIV Infections
Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa
The goal of this trial is to understand which strategies work best to support pre-exposure prophylaxis (PrEP) use among female sex workers (FSW) and adolescent girls and youth women (AGYW) in uMgungundlovu, KwaZulu-Natal, South…
- Trial name
- NCT06274060
- Testing
- Case management, Food vouchers, PrEP support buddy
- Where
- South Africa
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Human Papillomavirus Vaccines
Increasing Optimal Use of HPV Vaccination in Primary Care
Washington University will evaluate the effectiveness of a multi-component implementation strategy to increase use of HPV vaccine in primary care practices.
- Trial name
- NCT04180462
- Testing
- Practice Facilitation, Education, Audit and Feedback
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Evidence-Based Practices, CBT
A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy
This research project is a hybrid type 2 effectiveness-implementation trial that simultaneously examines (1) the effectiveness of a trauma-focused intervention for youth in the education sector and (2) the impact of a…
- Conditions
- Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
- Trial name
- NCT04451161
- Testing
- Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Pain
Pragmatic Trial of WHT vs. PC-GE to Promote Non-Pharmacological Strategies to Treat Chronic Pain in Veterans
The overarching goal of this Pain Management Collaboratory Demonstration project is to test a new Whole Health paradigm for chronic pain care, emphasizing non-pharmacological pain self-management that is hypothesized to reduce…
- Trial name
- wHOPE (NCT04330365)
- Testing
- Whole Health Team (WHT) Intervention Arm, Primary Care Group Education (PC-GE) Intervention Arm, Usual Primary Care (UPC) Arm
- Where
- 6 sites in United States
- Volunteers
- 793 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Cirrhosis, Liver
Using Data-Driven Implementation Strategies to Improve the Quality of Cirrhosis Care
This Veteran Affairs (VA) Quality Improvement project aims to understand which data-driven implementation strategies promote evidence based practices that improve high-quality care for Veterans with cirrhosis.
- Trial name
- NCT04178096
- Testing
- Quality Improvement Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Designing an Implementation Strategy for Lung Screening and Smoking Cessation Treatment in Community Health Centers
Tobacco use is the leading preventable cause of death in the US and a major driver of health disparities. Among our tools for reducing the harms of tobacco is lung cancer screening (LCS).
- Trial name
- SAILS-FQHC (NCT05447897)
- Testing
- Qualitative Group Interviews, Stakeholder advisory group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HIV Infections
Improving Treatment and Retention Adherence in Nontraditional Settings
This is a hybrid implementation-effectiveness study using both qualitative and quantitative methods. The research aims to examine whether providing a new, but approved, HIV once a month injection treatment…
- Trial name
- I-TRAINS (NCT04973254)
- Testing
- CAB-RPV LA, Standard treatment within an HIV clinic
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boston Medical Center
See One, Do One
Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units
General medical hospitals provide care for a disproportionate share of patients who misuse substances. Motivational interviewing (MI) is a well-recognized, evidenced-based substance use treatment.
- Conditions
- See One, Do One, Order One
- Trial name
- NCT01825057
- Testing
- See One, Do One, Order One
- Where
- United States
- Volunteers
- 1,211 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pit-and-Fissure Sealants
An Implementation Strategy for the Adoption of an Evidence-Based Guideline for Pit-and-Fissure Sealants
The purpose of this implementation science study is to determine whether Deliberative Loops are effective in increasing providers' adherence to the non-cavitated caries component of the American Dental Association's…
- Trial name
- DISGO (NCT04682730)
- Testing
- Deliberative Loop
- Where
- United States
- Volunteers
- 896 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Suicide
Adolescent and Child Suicide Prevention in Routine Clinical Encounters
The objective of this study is to compare two approaches to implement an evidence-based firearm safety promotion program, S.A.F.E. Firearm, in pediatric primary care as a universal suicide prevention strategy.
- Trial name
- ASPIRE (NCT04844021)
- Testing
- Nudge, Nudge+
- Where
- 2 sites in United States
- Volunteers
- 47,307 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Opioid Misuse, Chronic Pain
Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
The NIH Helping to End Addiction Long-term (HEAL) initiative has identified a critical next step to addressing the opioid crisis: improving treatments for opioid misuse behaviors (e.g., using more opioids than prescribed, illicit…
- Trial name
- NCT05182606
- Testing
- Pilot study of algorithms implementation package
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Human Immunodeficiency Virus, Hypertension
Integration of Hypertension Management Into HIV Care in Nigeria
This study evaluates a tailored-practice facilitation (PF) strategy for integrating a task strengthening strategy for hypertension control (TASSH) for the care of patients living with HIV (PWH) within primary health centers…
- Trial name
- TASSH NIMR (NCT04704336)
- Testing
- Task-shifting strategy for HTN control (TASSH) protocol
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 830 people
- Sponsor
- NYU Langone Health
Implementation, Behavioral Symptoms
Working to Implement and Sustain Digital Outcome Measures
This study will investigate the effects of an organizational implementation strategy called Leadership and Organizational Change for Implementation (LOCI), relative to training and technical assistance only, on fidelity to, and…
- Trial name
- WISDOM (NCT04096274)
- Testing
- Leadership for Organization Change and Implementation (LOCI), Training and Technical Assistance Only
- Where
- 4 sites in United States
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Boise State University
HIV Infections
A Study Evaluating Implementation Strategies for the Delivery of APRETUDE for Black cis-and Transgender Women in United States EHE Territories
The purpose of the study is to evaluate the appropriateness, adoption, feasibility, fidelity, and acceptability of implementation strategies and Cabotegravir (CAB) pre-exposure prophylaxis (PrEP).
- Trial name
- EBONI (NCT05514509)
- Testing
- APRETUDE, Cabotegravir tablet
- Where
- 22 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Smoking, Cigarette
Tobacco Use Treatment in Cancer Patients
Tobacco use among cancer survivors reduces the effectiveness of cancer treatments, increases the risk for additional primary cancers, and increases mortality.
- Trial name
- NCT03482583
- Testing
- Nicotine Replacement Therapy, Referral to AHEC/Quitline
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Systemic Lupus Erythematosus
Implementing the Decision-Aid for Lupus (IDEAL Strategy)
The study will attempt to put into practice a shared decision making (SDM) strategy, using an individualized, computerized decision- aid (DA) for Systemic lupus erythematosus (SLE).
- Trial name
- IDEAL (NCT03735238)
- Testing
- SMILE Computerized Decision-Aid
- Where
- United States
- Volunteers
- 1,895 people
- Sponsor
- University of Alabama at Birmingham
Atherosclerotic Cardiovascular Disease
A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)
The purpose of this study was to assess the effectiveness of an "inclisiran first" implementation strategy (addition of inclisiran to maximally tolerated statin therapy immediately upon failure to achieve acceptable LDL-C with…
- Trial name
- V-INITIATE (NCT04929249)
- Testing
- Inclisiran
- Where
- 43 sites in United States
- Volunteers
- 450 people
- Sponsor
- Novartis Pharmaceuticals