Clinical trials: Implementation Science
Preterm Birth, Activity Restriction
DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention
DE-RESTRICT is a pilot study testing whether a strategy to reduce the use of activity restriction and bedrest in pregnancy is acceptable, appropriate, and feasible for prenatal care providers, and whether it changes how often…
- Conditions
- Preterm Birth, Activity Restriction, Bed Rest, Low-Value Care
- Trial name
- NCT07698483
- Testing
- Multicomponent deimplementation strategy
- Where
- 2 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Implementation Science, Diet, Food, and Nutrition
Sustainability Via Active Garden Education Wellness Implementation Strategies in Early Care and Education
This project compares four SAGE implementation strategies to evaluate effectiveness in implementation, sustainability, cost, and child health outcomes.
- Conditions
- Implementation Science, Diet, Food, and Nutrition, Child Care, Motor Behavior
- Trial name
- SAGE WISE (NCT07228819)
- Testing
- SAGE Basic, SAGE e-support, SAGE in-person support
- Where
- United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Adolescent HIV Infection, Transition to Adult Care
Scale-up of an Evidence-based Adolescent Transition Package to Support Transitional Care Among Youth Living With HIV
Ending the HIV epidemic for youth living with HIV will require implementation and optimization of evidence-based interventions that address barriers to treatment.
- Conditions
- Adolescent HIV Infection, Transition to Adult Care, Implementation Science, Implementation Strategies
- Trial name
- ATTACH-Scale (NCT06924073)
- Testing
- ATP-Youth Enhanced Strategy (ATP-YES)
- Where
- 25 sites in Kenya
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tuberculosis, Latent Tuberculosis
Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial)
The Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial) study will be a three-arm, open-label, parallel, randomized trial.
- Conditions
- Tuberculosis, Latent Tuberculosis, HIV/AIDS
- Trial name
- NCT03934931
- Testing
- Streamlined weekly DOT visits, Weekly DOT visit reminders, Cost reimbursement DOT
- Where
- Uganda
- Volunteers
- 1,656 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Implementation Science
Leveraging Telepsychology and Behavioral Economics to Increase Fidelity to CBT
The goal of this study is to develop and test a telehealth tool intended to support community mental health clinicians to deliver cognitive behavioral therapy (CBT). The main aims of the study are to: 1.
- Trial name
- BENEFITS (NCT06601062)
- Testing
- Tele-BE
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mental Health, Parenting Stress
SBIR/ STTR Family Check-up Online
The Family Check-Up Online, a digital health intervention, was designed to improve child mental health through family-centered intervention.
- Conditions
- Mental Health, Parenting Stress, Academic Achievement, Parenting Skills
- Trial name
- NCT06876246
- Testing
- Family Check-Up Online, FCU Online with Telehealth Coaching
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Recurrent Urinary Tract Infection
EHR-integrated rUTI Texting Platform
The goal of this clinical trial is to compare a texting platform to usual care for managing recurrent urinary tract infections (UTI).
- Trial name
- Urotrust (NCT06035601)
- Testing
- EHR-integrated texting platform (Urotrust), Usual care
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer
Cancer Prevention and Early Detection Among the Homeless Population: The Health Navigator Model
Prevention and early detection are key for the decrease of cancer-related mortality. However, socially deprived population groups don't have the privilege of unburdened access to the healthcare system.
- Trial name
- CANCERLESS (NCT05406687)
- Testing
- Health Navigator Model
- Where
- 18 sites in Austria, Greece and 2 more
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Substance Abuse
Efficacy of Centervention-ATOD: An Implementation Tool for Dissemination of Evidence-based Programs for Substance Abuse
The pilot test of Centervention-ATOD, a customizable suite of online tools specifically designed to support quality implementation and sustainability of any ATOD-EBP within real-world service settings, will evaluate whether the…
- Trial name
- CV-ATOD (NCT03084406)
- Testing
- Centervention-ATOD (CV-ATOD)
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- 3-C Institute for Social Development
Dementia, Cognitive Dysfunction
Preventing Loss of Independence Through Exercise in Community Living Centers
Approximately 40,000 older Veterans with complex care needs receive long-term care in VA Community Living Centers (CLCs). Many CLC staff have limited specialized training to engage Veterans with dementia.
- Trial name
- PLIE-CLC (NCT06972004)
- Testing
- Preventing Loss of Independence through Exercise (PLIE)
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Human Papilloma Virus Infection, Carcinoma in Situ of Uterine Cervix
Community-Driven Cervical Cancer Prevention in Western Kenya
There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies.
- Trial name
- NCT02124252
- Testing
- Community-based testing with standard linkage to care, Community-based HPV testing with enhanced linkage to care
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Colo-rectal Cancer
Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study
The investigators will use a mixed methods study i.e. focus groups involving CHC staff as well as quantitative study which involves analyzing data that is available from the EHR and DRVS population management platform.
- Trial name
- NCT05524428
- Testing
- Implementation Science Strategy
- Where
- 4 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stress, Postpartum Depressive Disorder
Powerly - Science-based Digital Intervention Preventing Postpartum Depression and Anxiety
The goal of this clinical trial is to determine if the Powerly app can help prevent postpartum depression and anxiety in healthy pregnant women.
- Conditions
- Stress, Postpartum Depressive Disorder, Postpartum Anxiety
- Trial name
- POWERLY app (NCT06610552)
- Testing
- Powerly
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Marta Marciniak
Maternal Mortality Disparities, Maternal Morbidity Disparities
Scaling up Maternal Health Equity Best Practices
This study works with prenatal and postnatal care providers in 12 Michigan counties to scale up best practices for maternal health equity.
- Trial name
- NCT06541951
- Testing
- Services as usual, Scale-up implementation approach
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Michigan State University
HIV
CHWs, mHealth, and Combination HIV Prevention
Kasensero, a fishing community on Lake Victoria in Uganda, is a representative HIV "hotspot" with extremely high HIV prevalence (44.3%) and incidence (~3.9/100py), yet low HIV service utilization.
- Trial name
- mLAKE (NCT02556957)
- Testing
- HealthScouts, Standard of Care
- Where
- Uganda
- Volunteers
- 3,773 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HPV Vaccine
Effectiveness of Vaccine Chatbot on HPV Vaccine Awareness and Vaccination in China
This interventional study targets female students in junior middle school. It goal is to evaluate the effectiveness of a vaccine chatbot on HPV vaccine awareness and vaccination. The main questions it aims to answer are: 1.
- Trial name
- NCT06227689
- Testing
- Vaccine chatbot that offering HPV vaccine-related information
- Where
- 2 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Fudan University
Tuberculosis, Pulmonary, Rifampicin Resistant Tuberculosis
GeneXpert Performance Evaluation for Linkage to Tuberculosis Care
The investigators' overall objective is to assess the effectiveness, implementation and costs of a streamlined TB diagnostic evaluation strategy based around rapid, onsite molecular testing.
- Trial name
- XPEL-TB (NCT03044158)
- Testing
- GeneXpert I, Process re-design, Performance Feedback
- Where
- 20 sites in Uganda
- Volunteers
- 10,644 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sickle Cell Disease
Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea Utilization
This project proposes to develop, test and evaluate targeted interventions to improve clinical provider prescribing of and patient adherence to hydroxyurea (HU).
- Trial name
- NCT04080167
- Testing
- InCharge Health mobile application, HU Toolbox mobile application
- Where
- 7 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Implementation Science, Informed Consent
Implementing a Novel Consent Process for Biospecimen Research After Newborn Screening
The purpose of this study is to implement an electronic consent education process for the retention and research use of residual dried bloodspots at four hospitals in Michigan and assess the impact of the new education, both on…
- Conditions
- Implementation Science, Informed Consent, Neonatal Screening
- Trial name
- MICI (NCT06192511)
- Testing
- Educational Website and Video
- Where
- 2 sites in United States
- Volunteers
- 5,980 people, healthy volunteers welcome
- Sponsor
- Erin Rothwell
Psychological Trauma, Mental Health
Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies
The purpose of this study is to partner with the North Carolina Child Treatment Program (NC CTP) and the SAMHSA-funded National Child Traumatic Stress Network (NCTSN) to develop and pilot the Collaborative Organizational Approach…
- Trial name
- COAST-IS (NCT03799432)
- Testing
- COAST-IS, TF-CBT Learning Collaborative
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine